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Drug-Target Interaction

Drug

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PubChem ID:3038525
Structure:
Synonyms:
209410-46-8
5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6H-pyrimido(1,6-b)pyridazin-6-one
6H-Pyrimido(1,6-b)pyridazin-6-one,
6H-Pyrimido(1,6-b)pyridazin-6-one, 5-(2,6-dichlorophenyl)-2-((2,4-difluorophenyl)thio)-
VX-745
VX745, VX-745
ZINC13493055

Target

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Uniprot ID:ABL1_HUMAN
Synonyms:
Abelson murine leukemia viral oncogene homolog 1
c-ABL
p150
Proto-oncogene tyrosine-protein kinase ABL1
EC-Numbers:2.7.10.2
Organism:Homo sapiens
Human
PDB IDs:1AB2 1ABL 1AWO 1BBZ 1JU5 1OPL 1ZZP 2ABL 2E2B 2F4J 2FO0 2G1T 2G2F 2G2H 2G2I 2GQG 2HIW 2HYY 2HZ0 2HZ4 2HZI 2O88 2V7A 3CS9 3EG0 3EG1 3EG2 3EG3 3EGU
Structure:
3EGU

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
-710--
-730--
-870--
-1200--
-1500--
-1700--
-1800--
-2200--
-2300--
-7200--
->10000--

References: