Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:3033769
Structure:
Synonyms:
"benzamide, 3,5-dichloro-n-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-(methoxy-(sup)11 c)-, (s)-;"
3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2-hydroxy-6-methoxybe
97849-54-2
A-40664
AC1MHWAC
Benzamide, 3,5-dichloro-N-((1-ethyl-2-pyrrolidinyl)-methyl)-2-hydroxy-6-(methoxy-(sup)11 C)-, (S)-;
Biomol-NT_000027
BPBio1_001215
BRD-K04111260-001-01-9
CCG-100752
CHEBI:104672
CHEMBL8809
CPD000449275
HMS2051C03
HMS2089C20
HMS2232D05
MLS000758220
MLS001423957
NCGC00025303-01
NCGC00025303-02
NCGC00025303-03
NCGC00025303-04
NCGC00025303-05
PDSP1_000924
Raclopride
Raclopride C 11
Raclopride C 11 [USAN]
S(+)-Raclopride L-tartrate
SAM001247072
SMR000449275
Tocris-1810

Target

show target details
Uniprot ID:Q62710_RAT
Synonyms:
Nitric oxide synthase
EC-Numbers:-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

16252690
Influence of local administration of apomorphine on citrulline extracellular level in the striatum: participation of the dopamine D1 and D2 receptors. S A Savel'ev (2005) Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk display abstract
By means of in vivo microdialysis combined with HPLC analysis, we have shown that local infusions of 1 mM N-nitro-L-arginine (NO-synthase inhibitors) in the rat striatum reduced, and infusions of 100 microM apomorphine (agonists of the dopamine receptors) increased the level of citrulline (a NO co-product) in extracellular space of this structure. The apomorphine-induced increase in citrulline extracellular levels in the striatum was completely prevented by infusions of N-nitro-L-arginine in this structure, and 10 microM raclopride (dopamine D2 receptor blocker), but not by infusions of 50 microM SCH-23390 (dopamine D1 receptor blocker). The data obtained suggest that the increase in citrulline extracellular levels in striatum resulted from local activation of NO-synthase, and this effect is mediated by D2 rather than D1 dopamine receptors.