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Drug-Target Interaction

Drug

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PubChem ID:2977
Structure:
Synonyms:
(-)-.delta.-(sup8)-trans-Tetrahydrocannabinol
(-)-.DELTA.6-Tetrahydrocannabinol
(-)-.DELTA.8-Tetrahydrocannabinol
(-)-.DELTA.8-trans-Tetrahydrocannabinol
(-)-delta(sup 6)-3,4-trans-Tetrahydrocannabinol
(-)-delta(sup 8)-trans-Tetrahydrocannabinol
(-)-delta-(sup8)-trans-Tetrahydrocannabinol
(-)-delta8-Tetrahydrocannabinol
.delta.-(sup6)-THC
.delta.-(sup8)-THC
.delta.-8-THC
.DELTA.1(6)-Tetrahydrocannabinol
.DELTA.1(6)-trans-Tetrahydrocannabinol
.DELTA.6-Tetrahydrocannabinol
.delta.6-THC
.DELTA.8-Tetrahydrocannabinol
.DELTA.8-THC
.DELTA.8-trans-Tetrahydrocannabinol
1-trans-.delta.-(sup8)-Tetrahydrocannabinol
1-trans-delta(sup 8)-Tetrahydrocannabinol
1-trans-delta-(sup8)-Tetrahydrocannabinol
5-17-04-00421 (Beilstein Handbook Reference)
5957-75-5
6,6,9-Trimethyl-3-pentyl-6a,7,10,10a-tetrahydro-6H-benzo[c]chromen-1-ol
6H-Dibenzo(b,d)pyran-1-ol,
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-3-pentyl-6,6,9-trimethyl-, trans(-)-
6H-DIBENZO(b,d)PYRAN-1-OL, 6a,7,10,10a-TETRAHYDRO-6,6,9-TRIMETHYL-3-PENTYL-
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-(-)-
6H-Dibenzo(b,d)pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-(-)- (8CI)
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, (6aR-trans)-
6H-Dibenzo[b,d]pyran-1-ol, 6a,7,10,10a-tetrahydro-6,6,9-trimethyl-3-pentyl-, trans-(-)-
BRN 0023921
C21H30O2
Cannabinol, .DELTA.1(6)-tetrahydro-
Cannabinol, 1-trans-.delta.-(sup8)-tetrahydro-
Cannabinol, 1-trans-delta(sup 8)-tetrahydro-
Cannabinol, 1-trans-delta-(sup8)-tetrahydro-
Cannabinol, delta1(6)-tetrahydro-
DEA No. 7370
delta(sup 6)-Thc
delta(sup 8)-Thc
delta-(sup6)-THC
delta-(sup8)-THC
delta-8-Tetrahydrocannabinol
delta1(6)-trans-Tetrahydrocannabinol
delta6-Tetrahydrocannabinol
delta8-THC
DivK1c_000978
IDI1_000978
KBio1_000978
LS-61180
NCGC00168257-01
NINDS_000978
NSC 134453
NSC134453
TETRAHYDROCANNABINOL
Tetrahydrocannabinols
Tetrahydrocannabinols (-)-delta6-3,4-trans-form
WLN: T B666 HO MU&TTJ CQ E5 I1 I1 M1

Target

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Uniprot ID:ACES_RAT
Synonyms:
Acetylcholinesterase
AChE
EC-Numbers:3.1.1.7
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

148840
Effects of cannabinoids on synaptic membrane enzymes. I. In vitro studies on synaptic membranes isolated from rat brain.. C A Olmsted (1976) The American journal of drug and alcohol abuse display abstract
The understanding of the effects of cannabinoids in human subjects has been obscured by a lack of knowledge about how the various active principles from marijuana act at the cellular level in the brain. For this reason the present study was undertaken to determine the effects of cannabinoids on the enzymes associated with the synaptic membranes. Electron micrographic analysis was performed to determine the purity of synaptic membrane preparations from rat brain, and subsequently such preparations were subjected to additions of ethanol, Tween-80, 80% glycerol, and either delta-tetrahydrocannabinol, 11-hydroxy-delta-tetrahydrocannabinol, or cannabinol. Both sodium and potassium activated ATPase (Na, K-ATPase), and Mg-ATPase were measured as the micrometer orthophosphate (P) released per minute per microgram membrane protein and these specific activities of the enzymes expressed as absolute values and as the percentage depression brought about by the cannabinoids. The ATPase spcific activities are taken from the rate curve over a 30-min incubation time. Additionally, synaptic membrane acetylcholineesterase specific activity was measured by continuous rate enzyme assay. While as low as 10 M delta-tetrahydrocannabinol showed appreciable decrements in both the membrane-bound ATPases, the other cannabinoids did not show such a great depression in enzyme activity. The specific activity of acetylcholinesterase, which is weakly bound to the membrane, showed only slight or no changes in activity with the various cannabinoids. It was additionally shown that the cannabinoids, delta-tetrahydrocannabinol in particular, bound to the synaptic membranes almost irreversibly in the in vitro system, and that the vehicle for dissolving the cannabinoids, while used as background control values when calculating the percentage decrements in enzyme specific activity, did vary the effects on the ATPase enzymes in particular. These data are discussed in relation to psychotomimetic activity of the cannabinoids.