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Drug-Target Interaction

Drug

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PubChem ID:2949
Structure:
Synonyms:
1-ethynyl-10a,12a-dimethyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-
17 beta-Hydroxy-2,4,17alpha-pregnadien-20-yno[2,3-d]-isoxazole
17.alpha.-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol
17230-88-5
AC1L1EU2
Chronogyn
Danazol
Danocrine
Danol
I14-2512
MLS003115428
NSC270916
Oprea1_249465
Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol, (17.alpha.)-
SMR001491646
STK801350
WIN 17,757
Win 17757
Winobanin
Side-Effects:
Side-EffectFrequency
emotional lability0
hirsutism0
gum hemorrhage0
spasm0
anxiety0
vomiting0
pelvic pain0
sleep disorder0
convulsions0
sweating0
gastroenteritis0
fatigue0
cataract0
nipple discharge0
metrorrhagia0
nausea0
headache0
leukopenia0
flushing0
pancreatitis0
eosinophilia0
arthralgia0
muscle cramps0
tremor0
photosensitivity0
alopecia0
tumor0
syncope0
hoarseness0
urticaria0
purpura0
chills0
nasal congestion0
fever0
hematuria0
constipation0
seborrhea0
paresthesia0
weakness0
jaundice0
back pain0
weight gain0
sore throat0
amenorrhea0
pseudotumor cerebri0
carpal tunnel syndrome0
polycythemia0
pruritus0
dizziness0
joint swelling0
edema0
adenomas0
stevens - johnson syndrome0
hemorrhage0
nervousness0
leukocytosis0
thrombocytopenia0
acne0

Target

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Uniprot ID:ESR1_HUMAN
Synonyms:
ER
ER-alpha
Estradiol receptor
Estrogen receptor
Nuclear receptor subfamily 3 group A member 1
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2B1Z 2B23 2BJ4 2FAI 2G44 2G5O 2I0J 2IOG 2IOK 2JF9 2JFA 2OCF 2OUZ 2P15 2POG 2Q6J 2Q70 2QA6 2QA8 2QAB 2QE4 2QGT 2QGW 2QH6 2QR9 2QSE 2QXM 2QXS 2QZO 2R6W 2R6Y 3CBM 3CBO 3CBP 3DT3 3ERD 3ERT
Structure:
3ERT

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: