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Drug-Target Interaction

Drug

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PubChem ID:294641
Structure:
Synonyms:
(2S)-2-Amino-2-[(5S)-3-chloro-4,5-dihydro-1,2-oxazol-5-yl]acetic acid
.alpha.-Amino-3-chloro-4,5-dihydro-[S-(R*,R*)]-5-isoxazoleacetatic acid
42228-92-2
5-Isoxazoleacetic acid, .alpha.-amino-3-chloro-4,5-dihydro-, [S-(R*,R*)]-
AC1L6MD4
ACIA
ACIVICIN
Acivicin (USAN/INN)
AIDS-010581
AIDS010581
Antibiotic AT 125
AT-125
BSPBio_003274
CCG-35436
CHEMBL1231101
D02755
DivK1c_000672
HMS502B14
IDI1_000672
KBio1_000672
KBio2_000823
KBio2_003391
KBio2_005959
KBio3_002775
KBioGR_001364
KBioSS_000823
NCGC00178172-01
NChemBio.2007.10-comp18
nchembio.212-comp11
NCI60_001241
NCIMech_000028
NINDS_000672
NSC-163501
NSC163501
SPECTRUM1502002
Spectrum3_001857
Spectrum4_000902
Spectrum5_001706
Spectrum_000343
U-42126

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11478776
Acivicin induces apoptosis independently of gamma-glutamyltranspeptidase activity.. H Aberkane; P Frank; M M Galteau; M Wellman (2001) Biochemical and biophysical research communications display abstract
Inhibition of cellular gamma-glutamyltranspeptidase (GGT) enzyme activity by its specific inhibitor acivicin is frequently used in studies aimed at demonstrating the physiological role of this enzyme. However, because acivicin is a glutamine antagonist, it also inhibits many other glutamine-dependent enzymes involved in purine and pyrimidine biosynthesis. The objective of the present work is to determine whether acivicin exhibits apoptotic properties and the significance of GGT activity level in the response to acivicin treatment. We compared acivicin (0-150 microM) effect on V79 cell lines expressing or not expressing human GGT. Apoptosis was assayed by annexin-V staining, cell cycle analysis, and caspase activation using flow cytometry. We found that acivicin causes a dose- and time-dependent apoptosis in the GGT-negative V79 cell line as well as in its GGT-positive counterpart line. This is the evidence that acivicin induces apoptosis in V79 cell independently of their GGT activity level.