Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:289
Structure:
Synonyms:
1,2-benzenediol
1,2-dihydroxybenzene
1,3-dihydroxybenzene
120-80-9
12385-08-9
135011_SIAL
16474-89-8
16474-90-1
2-(5,8-Dihydroxy-1-methoxy-3-methyl(2-naphthyl))-5-methoxy-7-methylnaphthalene-1,4-diol
2-hydroxyphenol
20244-21-7
20244-21-7 (unspecified hydrochloride salt)
37349-32-9
4-06-00-05557 (Beilstein Handbook Reference)
430749_ALDRICH
430749_SIAL
AB-131/40235236
AB1002105
AC1L18WM
AC1Q78GA
AG-D-45381
AI3-03995
AIDS-108194
AIDS108194
AKOS000119002
alpha-hydroxyphenol
BBL002408
BB_NC-2239
Benzcatechin
Benzene, o-dihydroxy-
benzene-1,2-diol
benzenediol
BIDD:ER0327
bmse000385
Brenzcatechin
BRN 0471401
C 9510
C.I. 76500
C.I. Oxidation Base 26
C00090
c0097
C01785
C034221
C15571
C3561_SIAL
C9510_SIAL
C9593_SIGMA
CAQ
Catechin
Catechin (phenol)
CATECHOL
Catechol (phenol)
catechol dipotassium salt
catechol sodium salt
catechol, 14C-labeled cpd
Catechol-pyrocatechol
Catechol-UL-14C
CCG-204375
CCRIS 741
CHEBI:18135
CHEMBL280998
CI 76500
CI Oxidation Base 26
DB02232
Dihydroxybenzene
Durafur developer C
Durafur Developer CFouramine PCH
EINECS 204-427-5
EU-0100280
Fouramine PCH
Fourrine 68
HMS2233A17
HMS3260H22
HSDB 1436
I01-2906
Katechol
Katechol [Czech]
Lopac-C-9510
Lopac0_000280
LS-637
MLS002153385
MLS002303022
MolPort-000-871-939
NCGC00015283-01
NCGC00015283-02
NCGC00015283-03
NCGC00015283-04
NCGC00015283-05
NCGC00015283-06
NCGC00015283-07
NCGC00015283-08
NCGC00091262-01
NCGC00091262-02
NCGC00091262-03
nchembio801-comp10
NCI-C55856
NSC 1573
NSC1573
o Dihydroxybenzene
o-Benzenediol
o-Dihydroxybenzene
o-Dioxybenzene
o-Diphenol
o-Hydroquinone
o-Hydroxyphenol
o-Phenylenediol
ortho-Benzenediol
ortho-Dihydroxybenzene
ortho-Dioxybenzene
ortho-Hydroquinone
ortho-Hydroxyphenol
ortho-Phenylenediol
Oxyphenic acid
P0317
P0567
Pelagol Grey C
phenol derivative, 2
Phthalhydroquinone
pyrocatechin
Pyrocatechine
Pyrocatechinic acid
Pyrocatechinic acidPyrocatechol
pyrocatechol
pyrocatechol-ul-14C
Pyrocatechuic acid
Pyrokatechin
Pyrokatechin [Czech]
Pyrokatechol
Pyrokatechol [Czech]
SMR000326660
ST5214346
STK398651
WLN: QR BQ
ZINC13512214

Target

show target details
Uniprot ID:PELB_COLGL
Synonyms:
Pectate lyase B
EC-Numbers:4.2.2.2
Organism:Anthracnose fungus
Colletotrichum gloeosporioides
Glomerella cingulata
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8012046
Purification of pectate lyase produced by Colletotrichum gloeosporioides and its inhibition by epicatechin: a possible factor involved in the resistance of unripe avocado fruits to anthracnose.. C Wattad; A Dinoor; D Prusky (1994) Molecular plant-microbe interactions : MPMI display abstract
Pectate lyase (PL) from Colletotrichum gloeosporioides was purified to apparent homogeneity by hydrophobic interaction chromatography followed by isoelectric focusing. The purified preparation showed one band corresponding to 40 kD on sodium dodecyl sulfate-polyacrylamide gels. The isoelectric point of the enzyme was 7.9, and the optimum pH for activity was 8.9. The purified PL efficiently macerated unripe avocado fruit wedges. In vitro translation of mRNA from an induced fungal culture revealed a 36-kD precursor polypeptide, which was precipitated with PL antibodies. The antibodies inhibited enzymatic activity and maceration ability on avocado wedges. Epicatechin, a flavan 3-ol present in the peel of unripe avocado fruit, had a Ki of 3.4 microM for inhibition of PL activity in vitro. At 20 micrograms/ml (68 microM), epicatechin reduced the enzyme's macerating ability by 64%. Since the flavan is present in unripe fruit at much higher concentrations (about 350 micrograms/g fresh weight) than the inhibitory concentrations, epicatechin may be involved in the resistance of unripe avocado fruits by inhibiting the PL activity of C. gloeosporioides.