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Drug-Target Interaction

Drug

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PubChem ID:284
Structure:
Synonyms:
06450_FLUKA
06460_FLUKA
06473_FLUKA
09676_FLUKA
141-53-7
141-53-7 (hydrochloride salt)
15843-02-4
15843-02-4 (unspecified nickel salt)
15907-03-6
15907-03-6 (unspecified copper salt)
27001_RIEDEL
27001_SIAL
27115-36-2
27115-36-2 (chromium(+3) salt)
33015_RIEDEL
33015_SIAL
3349-06-2
3349-06-2 (nickel(+2) salt)
3495-35-0
3495-35-0 (rubidium salt)
3495-36-1
3495-36-1 (cesium salt)
399388_SIAL
4464-23-7
4464-23-7 (cadmium salt)
49897_FLUKA
540-69-2
540-69-2 (ammonium salt)
544-17-2
544-17-2 (calcium salt)
544-18-3
544-18-3 (cobalt(+2) salt)
544-19-4
544-19-4 (copper(+2) salt)
556-63-8
556-63-8 (lithium salt)
557-39-1
557-39-1 (magnesium salt)
557-41-5
557-41-5 (zinc salt)
56302_FLUKA
590-29-4
590-29-4 (potassium salt)
592-89-2
592-89-2 (strontium salt)
63182-21-8
63182-21-8 (chromium(+3)-hydrochloride[4:1:1] salt)
64-18-6
68134-59-8
68134-59-8 (unspecified copper-nickel salt)
68310-83-8
68310-83-8 (unspecified copper-ammonium salt)
70179-79-2
70179-79-2 (ammonium[4:1] salt)
7056-83-9
7056-83-9 (unspecified lead salt)
7360-53-4
7360-53-4 (aluminum salt)
8006-93-7
811-54-1
811-54-1 (lead(+2) salt)
82069-14-5
94318_FLUKA
992-98-3
992-98-3 (thallium(+1) salt)
AB1002558
AC1L18W7
AC1Q77UV
acide carboxylique
Acide formique
Acide formique [French]
acide gras
acides carboxyliques
acides gras
acido carboxilico
Acido formico
Acido formico [Italian]
acido graso
acidos carboxilicos
acidos grasos
ACT
Add-F
AG-G-40638
AI3-24237
AKOS000269044
Ameisensaeure
Ameisensaeure [German]
Ameisensaure
Aminic acid
Bilorin
bmse000203
C00058
C1 acid
C1:0
Carbonsaeure
Carbonsaeuren
CARBOXY GROUP
carboxylic acid
carboxylic acids
CBX
CCRIS 6039
CHEBI:30751
CHEBI:33575
CHEBI:35366
CHEMBL116736
CO2
Collo-bueglatt
Collo-didax
DB01942
EINECS 200-579-1
EPA Pesticide Chemical Code 214900
F0507_SIAL
F0513
F0654
Fatty acids
FEMA No. 2487
Fettsaeure
FMT
Formate
Formate standard for IC
Formic acid
Formic acid (natural)
FORMIC ACID 88%
Formic acid solution
Formic acid [UN1779] [Corrosive]
Formic acid [UN1779] [Corrosive]
FORMIC ACID, ACS
Formira
Formisoton
Formylic acid
H-COOH
HCO2H
HCOOH
HSDB 1646
Hydrogen carboxylic acid
I14-8126
Karbonsaeure
Kwas metaniowy
Kwas metaniowy [Polish]
Kyselina mravenci
Kyselina mravenci [Czech]
LMFA01010040
LS-1540
LTBB002135
methaldehyde
Methanoic acid
Methanoic acid monomer
methoic acid
Mierenzuur
Mierenzuur [Dutch]
MolPort-000-871-952
Myrmicyl
NCGC00248718-01
nchembio.198-comp18
RC(=O)OH
RCRA waste no. U123
RCRA waste number U123
Spirit of formic acid
ST5214364
Sybest
UN1779
W248703_ALDRICH
Wonderbond Hardener M 600L

Target

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Uniprot ID:Q7VFP2_HELHP
Synonyms:
DNA gyrase
EC-Numbers:5.99.1.3
Organism:Helicobacter hepaticus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

10522711
Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose.. D Ferroud; J Collard; M Klich; C Dupuis-Hamelin; P Mauvais; P Lassaigne; A Bonnefoy; B Musicki (1999) Bioorganic & medicinal chemistry letters display abstract
A series of novobiocin-like coumarincarboxylic acids has been prepared bearing the L-rhamnosyl moiety as the sugar portion of the molecule. The similar DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates that L-rhamnose can effectively replace L-noviose. Introduction of alkyl side-chains at C-5 of coumarin leads to improved in vitro antibacterial properties in the novel series.