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Drug-Target Interaction

Drug

show drug details
PubChem ID:2818
Structure:
Synonyms:
3-chloro-6-(4-methylpiperazin-1-yl)-5H-benzo[c][1,5]benzodiazepine
5-25-11-00364 (Beilstein Handbook Reference)
5786-21-0
5H-Dibenzo(b,e)(1,4)diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(4-methyl-1-piperazinyl)-
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine
8-Chloro-11-(4-methyl-piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
AIDS-085399
AIDS085399
Ambap805
Asaleptin
Bio1_000436
Bio1_000925
Bio1_001414
Bio2_000310
Bio2_000790
BRN 0764984
C06924
C18H19ClN4
C6305_SIGMA
CAS-5786-21-0
CCRIS 9171
CHEBI:3766
CID2818
Clorazil
Clozapin
Clozapina
Clozapina [INN-Spanish]
Clozapine
Clozapine (JAN/USP/INN)
Clozapine [USAN:BAN:INN]
Clozapine [USAN:INN:BAN]
clozapine(tautomer)
Clozapine, Clozaril, Azaleptin, Leponex, Fazaclo, Froidir, Denzapine,
Clozapinum
Clozapinum [INN-Latin]
CLOZARIL
Clozaril (TN)
D00283
D003024
DB00363
DivK1c_000343
EINECS 227-313-7
EU-0100276
Fazaclo
Fazaclo ODT
HF-1854
HSDB 6478
Iprox
KBio1_000343
KBio2_000310
KBio2_000599
KBio2_002878
KBio2_003167
KBio2_005446
KBio2_005735
KBio3_000619
KBio3_000620
KBio3_002979
KBioGR_000310
KBioGR_001336
KBioSS_000310
KBioSS_000599
Leponex
Lepotex
LEX-123
Lopac-C-6305
LS-60881
MLS000028472
MLS001077282
NCGC00015254-01
NCGC00015254-02
NCGC00015254-03
NCGC00022902-02
NCGC00022902-04
NCGC00022902-05
NCGC00022902-06
NCGC00022902-07
NCGC00022902-08
NCGC00022902-09
NCGC00022902-10
NCGC00022902-11
NCGC00022902-13
NINDS_000343
Prestwick0_000350
Prestwick1_000350
Prestwick_693
QZUDBNBUXVUHMW-UHFFFAOYSA-
SMR000058365
SPBio_000798
SPBio_002340
SPECTRUM1500685
Spectrum2_000919
Spectrum3_001828
Spectrum4_000898
Spectrum_000139
Tocris-0444
W-801
ATC-Codes:
Side-Effects:
Side-EffectFrequency
drowsiness0.405
salivation0.35928568
tachycardia0.25
weight gain0.24928568
dizziness0.22000001
vertigo0.22000001
constipation0.18928571
insomnia0.15428571
dyspepsia0.12666667
vomiting0.10857142
hypotension0.09
nausea0.08578946
headache0.07
tremor0.059999995
dry mouth0.059999995
syncope0.059999995
sweating0.059999995
fever0.05
heartburn0.04
nightmares0.04
hypertension0.04
restlessness0.039999995
convulsions0.03
seizures0.03
leukopenia0.029999997
confusion0.029999997
neutropenia0.029999997
fatigue0.02
diarrhea0.02
rash0.019999998
incontinence0.01
nasal congestion0.01
chest pain0.01
shortness of breath0.01
urinary retention0.01
ataxia0.01
pain0.01
anxiety0.01
weakness0.01
muscle pain0.01
urinary urgency0.01
eosinophilia0.01
muscle weakness0.01
anorexia0.01
agranulocytosis0.01
angina0.01
cardiac abnormality0.01
throat discomfort0.01
muscle spasm0.0084999995
dyspnea0.0084999995
swelling0.0010
vasculitis0.0010
respiratory arrest0.0010
ventricular fibrillation0.0010
thrombocytopenia0.0010
impaired glucose tolerance0.0010
vein thrombosis0.0010
esr increased0.0010
cardiomyopathy0.0010
ketoacidosis0.0010
tardive dyskinesia0.0010
eeg abnormal0.0010
deep vein thrombosis0.0010
hyperuricemia0.0010
sepsis0.0010
thrombocytosis0.0010
weight loss0.0010
photosensitivity0.0010
cataplexy0.0010
hypersensitivity0.0010
hyperglycemia0.0010
hypercholesterolemia0.0010
hepatitis0.0010
heart failure0.0010
narrow angle glaucoma0.0010
glaucoma0.0010
fecal impaction0.0010
erythema multiforme0.0010
edema0.0010
drug abuse0.0010
diabetes0.0010
delirium0.0010
dysphagia0.0010
coma0.0010
acute pancreatitis0.0010
hypertriglyceridemia0.0010
hyponatremia0.0010
stevens - johnson syndrome0.0010
status epilepticus0.0010
rhabdomyolysis0.0010
pulmonary embolism0.0010
psychosis0.0010
priapism0.0010
pleural effusion0.0010
pericarditis0.0010
pericardial effusion0.0010
jaundice0.0010
mitral insufficiency0.0010
myocardial infarction0.0010
myocarditis0.0010
interstitial nephritis0.0010
paralytic ileus0.0010
paresthesia0.0010
thrombophlebitis0
memory loss0
gastric ulcer0
phlebitis0
palpitations0
sneezing0
petechiae0
dysmenorrhea0
dermatitis0
eyelid disorder0
hypothermia0
urinary frequency0
infection0
dysarthria0
irritability0
hallucinations0
arthralgia0
breast pain0
abdominal distention0
wheezing0
leukocytosis0
epistaxis0
cough0
dementia0
amnesia0
delusions0
laryngitis0
bradycardia0
eczema0
gastroenteritis0
arrhythmia0
anemia0
urticaria0
pruritus0
hematemesis0
ventricular extrasystoles0
rectal hemorrhage0
polydipsia0
numbness0
pneumonia0
eructation0
malaise0
hot flashes0
paranoia0
bronchitis0
nystagmus0
stuttering0
rhinorrhea0
impotence0
chills0
parkinson0
erythema0

Target

show target details
Uniprot ID:CP1A1_HUMAN
Synonyms:
CYPIA1
Cytochrome P450 1A1
P450 form 6
P450-C
P450-P1
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: