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Drug-Target Interaction

Drug

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PubChem ID:2788
Structure:
Synonyms:
130-26-7
22112-03-4
24880_ALDRICH
24880_FLUKA
33931_FLUKA
33931_RIEDEL
5 Chloro 7 iodo 8 quinolinol
5-21-03-00294 (Beilstein Handbook Reference)
5-Chlor-7-jod-8-hydroxy-chinolin
5-Chlor-7-jod-8-hydroxy-chinolin [German]
5-Chloro-7-iodo-8-hydroxyquinoline
5-Chloro-7-iodo-8-quinolinol
5-Chloro-7-iodo-quinolin-8-ol
5-Chloro-7-iodoquinolin-8-ol
5-Chloro-8-hydroxy-7-iodoquinoline
7-Iodo-5-chloro-8-hydroxyquinoline
7-Iodo-5-chloroxine
736176-41-3
8-Quinolinol, 5-chloro-7-iodo-
AB00384254
AC-6792
AC1L1EGW
AI3-16451
AIDS-020554
AIDS020554
AKOS000120779
Ala-Quin
Alchloquin
Alioform
Amebil
Amoenol
Bactol
Barquinol
BPBio1_000740
BRD-K09255212-001-04-2
BRN 0153637
BSPBio_000672
BSPBio_002466
Budoform
C8133_SIGMA
C9H5ClINO
CAS-130-26-7
Caswell No. 193
CCRIS 6050
CHEMBL497
Chinoform
Chinoformum
Chloro-8-hydroxyiodoquinoline
Chloroiodoquin
Chloroiodoquine
Chlorojodochin
Cifoform
Cliochinolo
Cliochinolo [DCIT]
Cliochinolum
Clioquinol
Clioquinol (USP/INN)
Clioquinol [BAN:INN]
Clioquinol [INN:BAN]
Clioquinolum
Clioquinolum [INN-Latin]
Cliquinol
component of Cort-Quin
component of Formtone-HC
component of Heb-Cort V
component of Hyquin
component of Vioform-Hydrocortisone
Corque
Cort-Quin
Cortin
CQL
Cremo-quin
CU-01000000767-2
D007464
D03538
DB04815
Dermaform
Dioquinol
Domeform
Domeform-HC
Eczecidin
EINECS 204-984-4
Emaform
Enteritan
Entero Septol
Entero Vioform
Entero-bio form
Entero-Bioform
Entero-Septol
Entero-Vioform
Entero-Vioformio
Enteroquinol
Enteroseptol
Enterovalodon
EnteroVioform
Enterozol
Enterseptol
Enterum locorten
Entrokin
EPA Pesticide Chemical Code 024001
Formtone-HC
Hi-eneterol
Hi-Enterol
HMS1570B14
HMS1648J07
HMS2093I12
HMS2097B14
HMS2230I20
HSDB 6843
Hydriodide-enterol
Hysone
I01-1475
IN1375
Iodenterol
Iodo
Iodochlorhydroxyquin
Iodochlorhydroxyquin Cream
Iodochlorhydroxyquinol
Iodochlorhydroxyquinoline
Iodochlorohydroxyquin
Iodochlorohydroxyquinoline
Iodochloroquine
Iodochloroxine
Iodochloroxychinolinum
Iodochloroxyquinoline
Iodoenterol
Iodoxyquinoline
Jodchloroxychinolinum
ksc-8-192
KUC105859N
Lekosept
Lidaform-HC
Linolasept
loquinol
LS-725
Mixture Name
MLS000069389
MLS002454410
MolPort-000-146-025
Mycoquin
NCGC00016391-01
NCGC00016391-02
NCGC00016391-03
NCGC00016391-04
NCGC00016391-05
NCGC00016391-06
NCGC00016391-07
NCGC00016391-08
NCGC00016391-09
NCGC00016391-10
NCGC00021665-03
NCGC00021665-04
NCGC00021665-05
nchembio.65-comp1
NCIOpen2_009062
Nioform
NSC 3531
NSC3531
Nystaform
Nystaform-HC
Oprea1_438281
Oralcer
PBT-1
Prestwick0_000886
Prestwick1_000886
Prestwick2_000886
Prestwick3_000886
Quin-O-Creme
Quinambicide
Quinoform
Quinoform (antiseptic)
Quinoform (VAN)
Quinoline, chloro-8-hydroxyiodo-
Racet
Rheaform
Rheaform Boluses (Veterinary)
Rometin
SB 01341
SBB032280
SMP1_000073
SMR000058282
SPBio_002891
SPECTRUM1505114
STK399761
TG2-36-2
UAD Lotion
UNII-7BHQ856EJ5
Vioform
Vioform N.N.R
Vioform n.n.r.
Vioform-Hydrocortisone
Vioform-Hydrocortisone Mild
Vioformio
WLN: T66 BNJ GG II JQ
ZINC06409735
ATC-Codes:

Target

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Uniprot ID:CASP3_MOUSE
Synonyms:
Apopain
CASP-3
Caspase-3
CPP-32
Cysteine protease CPP32
LICE
SCA-1
SREBP cleavage activity 1
Yama protein
EC-Numbers:3.4.22.56
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

15833873
Anticancer activity of the antibiotic clioquinol.. Wei-Qun Ding; Bolin Liu; Joshua L Vaught; Hanako Yamauchi; Stuart E Lind (2005) Cancer research display abstract
Clioquinol, a metal chelator, has been used for many years as an antimicrobial agent and more recently as a potential treatment for Alzheimer's disease. Because it binds copper and zinc, metals essential for the activity of the enzyme superoxide dismutase-1 (SOD1), a potential target for anticancer drug development, we investigated its effects on human cancer cells. Treatment with clioquinol reduced the viability of eight different human cancer cell lines in a concentration-dependent manner, with IC(50) values in the low micromolar range. Biochemical analysis revealed that clioquinol induced cancer cell death through apoptotic pathways that require caspase activity. Although clioquinol induced modest inhibition of SOD1 activity in treated cells, comparable inhibition by a known SOD1 inhibitor, diethyldithiocarbamate, did not result in cytotoxicity. The addition of copper, iron, or zinc did not rescue cells from cliquinol-induced cytotoxicity but enhanced its killing, arguing against metal chelation as its major mechanism of action. To test if clioquinol might act as an ionophore, a fluorescent probe was used to monitor intracellular zinc concentrations. The addition of clioquinol resulted in elevated levels of intracellular zinc, indicating that clioquinol acts as a zinc ionophore. In an in vivo xenografts mouse model, clioquinol inhibited tumor growth of xenografts over a 6-week period, without inducing visible toxicity. Our results show that clioquinol has anticancer effects both in vitro and in vivo. Transition metal ionophores may be a subclass of metal chelators with anticancer activity deserving of further development.