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Drug-Target Interaction

Drug

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PubChem ID:273
Structure:
Synonyms:
1,5-Amylene diamine
1,5-Diamino-n-pentane
1,5-Diaminopentane
1,5-Pentamethylenediamine
1,5-Pentanediamine
1476-39-7
1948270A-6D1B-4F40-BC13-9B680ED17B17
4-04-00-01310 (Beilstein Handbook Reference)
462-94-2
AC1L18VA
AC1Q54G4
AI3-26937
AKOS005169829
alpha,omega-Pentanediamine
Animal coniine
AR-1I1466
BB_NC-2202
BioDex 1-
bmse000072
BRN 1697256
C01672
Cadaverin
Cadaverine
CHEBI:18127
CHEBI:295271
CHEMBL119296
D0108
D22606_ALDRICH
DB03854
EINECS 207-329-0
FT-0082782
I14-3334
LS-101555
MolPort-002-317-350
N2P
NCGC00166285-01
Pentamethylenediamine
pentane-1,5-diamine

Target

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Uniprot ID:A4TB13_MYCGI
Synonyms:
Amine oxidase (Copper-containing)
EC-Numbers:1.4.3.6
Organism:Mycobacterium flavescens (strain ATCC 700033 / PYR-GCK
Mycobacterium gilvum
strain PYR-GCK
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

1799365
Competition of homologous substrates, putrescine and cadaverine, in the reaction catalyzed by pea diamine oxidase.. P Pec; I Frébort (1991) Biochemistry international display abstract
The determination of diamine oxidase activity with the ninhydrin reagent was used for monitoring of simultaneous oxidation of two homologous substrates, putrescine and cadaverine, which give different colour products (519 and 417 nm). We measured the reaction rates of oxidation of both substrates in different proportion and compared them with the total reaction rate determined by the guaiacol method. The substrates show competition with inhibition constants of putrescine against cadaverine of 0.14 mmol.l-1 and cadaverine against putrescine of 6.4 mumol.l-1.