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Drug-Target Interaction

Drug

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PubChem ID:2726
Structure:
Synonyms:
10-(3-Dimethylaminopropyl)-2-chlorophenothiazine
10-(3-Dimethylaminopropyl)-2-chlorophenothiazine;
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-
10h-phenothiazine-10-propanamine, 2-chloro-n,n-dimethyl-, radical ion(1)
10H-Phenothiazine-10-propanamine, 2-chloro-N,N-dimethyl-, radical ion(1+)
2-chloro-10-(3-(dimethylamino)propyl)-phenothiazine
2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine
2-chloro-10-[3-(dimethylamino)propyl]-
2-Chloro-10-[3-(dimethylamino)propyl]phenothiazine
2-Chloro-N,N-dimethyl-10H-phenothiazine-10-propanamine
2-Chloropromazine
2-Cloro-10 (3-dimetilaminopropil)fenotiazina
2-Cloro-10 (3-dimetilaminopropil)fenotiazina [Italian]
2601A
3-(2-Chloro-10H-phenothiazin-10-yl)-N,N-dimethyl-1-propanamine
3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine
3-(2-chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine
3-(2-chlorophenothiazin-10-yl)-N,N-dimethylpropan-1-amine
34468-21-8
4560 R.P
4560 R.P.
4560 Rp hydrochloride
50-53-3
69-09-0 (HYDROCHLORIDE)
AB
AB00051943
AC1L1EBT
AIDS-007224
AIDS007224
AKOS001490972
Aminasine
Aminazin
Aminazin monohydrochloride
Aminazine
Ampliactil
Ampliactil monohydrochloride
Amplicitil
Amplictil
BAS 00010434
BC 135
Bio1_000457
Bio1_000946
Bio1_001435
Biomol-NT_000020
BPBio1_000273
BPBio1_001181
BSPBio_000247
BSPBio_002011
C06906
C17H19ClN2S
CAS-69-09-0
CCG-40059
CCRIS 3711
CHEBI:3647
CHEMBL71
Chlor-Promanyl
Chlor-PZ
Chloractil
Chlorazine
Chlordelazin
Chlordelazine
Chlorderazin
Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine
Chloro-3 (dimethylamino-3 propyl)-10 phenothiazine [French]
Chloropromazine
Chlorpromados
Chlorpromanyl (discontinued)
Chlorpromazin
Chlorpromazine
Chlorpromazine (USP/INN)
Chlorpromazine hibenzate
Chlorpromazine hydrochloride
Chlorpromazine phenolphthalinate
Chlorpromazine Tannate
Chlorpromazine [USAN:BAN:INN]
Chlorpromazine [USAN:INN:BAN]
Chlorpromazinium chloride
Chlorpromazinum
Chlorpromazinum [INN-Latin]
Chlropromados
CID2726
Clorpromazina
Clorpromazina [INN-Spanish]
Clorpromazina [Italian]
cMAP_000017
Contomin
CPZ
Cromedazine
D00270
DB00477
DivK1c_000624
EINECS 200-045-8
Elmarin
Esmind
Fenactil
Fenactil monohydrochloride
Fenaktyl
Fraction
Fraction AB
Hebanil
Hibanil
Hibernal
HL 5746
HMS1920M03
HMS2089C12
HMS2091E06
HMS501P06
HSDB 3033
Hybernal
I14-6226
IDI1_000624
JHICC02042
KBio1_000624
KBio2_000622
KBio2_002312
KBio2_003190
KBio2_004880
KBio2_005758
KBio2_007448
KBio3_001231
KBio3_002792
KBioGR_000806
KBioGR_002312
KBioSS_000622
KBioSS_002314
Klorproman
Klorpromex
L000182
Largactil
Largactil Liquid
Largactil Oral Drops
Largactilothiazine
Largactyl
Lomazine
Lopac-C-8138
Lopac0_000249
LS-105361
Megaphen
N-(3-Dimethylaminopropyl)-3-chlorophenothiazine
NCGC00015273-01
NCGC00015273-02
NCGC00015273-03
NCGC00015273-04
NCGC00015273-05
NCGC00015273-06
NCGC00015273-07
NCGC00015273-08
NCGC00015273-09
NCGC00015273-10
NCGC00015273-11
NCGC00015273-12
NCGC00015273-13
NCGC00015273-14
NCGC00015273-15
NCGC00015273-16
NCGC00015273-17
NCGC00024409-04
NCGC00024409-05
NCGC00024409-06
NCGC00024409-07
NCGC00024409-08
NCGC00024409-09
NCI-C05210
Neurazine
NINDS_000624
Norcozine
Novo-Chlorpromazine
Novomazina
NSC 167745
NSC167745
NSC17479
NSC17479 (HYDROCHLORIDE)
Oprea1_110255
Phenactyl
Phenathyl
Phenothiazine
Phenothiazine hydrochloride
Phenothiazine, 2-chloro-10-(3-(dimethylamino)propyl)-
Phenothiazine, 2-chloro-10-[3-(dimethylamino)propyl]-
Plegomasine
Plegomazin
Prazilpromactil
Prestwick0_000064
Prestwick1_000064
Prestwick2_000064
Prestwick3_000064
Proma
Promachel
Promacid
Promactil
Promapar
Promazil
Promexin
Propaphen
Propaphenin
Prozil
Prozin
Psychozine
QSPL 401
QTL1_000021
RP 4560
Sanopron
SKF 2601-A
SKF 2601A
SKF-2601
Sonazine
SPBio_001111
SPBio_002168
SPECTRUM1500184
Spectrum2_001156
Spectrum3_000346
Spectrum4_000283
Spectrum5_000717
Spectrum_000142
SR-01000000012-5
STK182870
STOCK1S-46588
Thorazine
Thorazine (TN)
Thorazine hydrochloride
Thorazine Spansule
Thorazine Suppositories
Torazina
Tranzine
UNII-U42B7VYA4P
Unitensen
Wintermin
WLN: T C666 BN ISJ B3N1&1 EG
Z80
[3-(2-Chloro-phenothiazin-10-yl)-propyl]-dimethyl-amine
ATC-Codes:
Side-Effects:
Side-EffectFrequency
allergic reaction0
pancytopenia0
dyspnea0
urinary retention0
spasm0
seizures0
blood dyscrasia0
exfoliative dermatitis0
mitral insufficiency0
asthma0
insomnia0
hypotension0
endocrine disorders0
tachycardia0
postural hypotension0
dysphagia0
pigmentary retinopathy0
leukopenia0
shock0
gynecomastia0
infection0
somnolence0
cardiac arrest0
cough0
petit mal0
priapism0
tremor0
photosensitivity0
tardive dyskinesia0
syncope0
peripheral edema0
aplastic anemia0
grand mal0
sore throat0
amenorrhea0
pheochromocytoma0
glycosuria0
purpura0
eosinophilia0
nasal congestion0
fever0
parkinson0
paralytic ileus0
anemia0
angioedema0
jaundice0
contact dermatitis0
hepatitis infectious0
impotence0
abnormal vision0
dry mouth0
agranulocytosis0
urticaria0
influenza0
hemolytic anemia0
constipation0
dizziness0
hypoglycemia0
liver disease0
edema0
cirrhosis0
torticollis0
hyperglycemia0
lupus0

Target

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Uniprot ID:KCNH2_HUMAN
Synonyms:
eag homolog
Eag-related protein 1
Erg1
Ether-a-go-go-related gene potassium channel 1
Ether-a-go-go-related protein 1
H-ERG
Potassium voltage-gated channel subfamily H member 2
Voltage-gated potassium channel subunit Kv11.1
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1BYW 1UJL
Structure:
1UJL

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--1470-
--5830-

References: