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Drug-Target Interaction

Drug

show drug details
PubChem ID:2720
Structure:
Synonyms:
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-, 1,1-dioxide
58-94-6
6-chloro-1,1-dioxo-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide;
6-chloro-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
AC-18732
AC1L1EBB
AIDS-047885
AIDS047885
Aldoclor
ALDOCLOR-150
ALDOCLOR-250
Alurene
BIDD:GT0635
BPBio1_000070
BRD-K88682005-001-05-9
BSPBio_000062
BSPBio_002003
C 4911
C07461
C2259
C4911_SIGMA
C7H6ClN3O4S2
CAS-58-94-6
CCG-38953
CCRIS 5999
CHEBI:3640
CHEMBL842
Chloriazid
Chlorosal
Chlorothiazid
Chlorothiazide
Chlorothiazide (JAN/USP/INN)
CHLOROTHIAZIDE AND RESERPINE
CHLOROTHIAZIDE SODIUM
CHLOROTHIAZIDE W/ RESERPINE
Chlorothiazide [USAN:BAN:INN]
Chlorothiazide [USAN:INN:BAN]
CHLOROTHIAZIDE-RESERPINE
Chlorothiazide-Supplied by Selleck Chemicals
Chlorothiazidum
Chlorothiazidum [INN-Latin]
chlorotiazida
Chlorthiazid
Chlorthiazide
Chlorthiazidum
Chlortiazid
Chlorurit
Chlotride
Chlrosal
Clorotiazida
Clorotiazida [INN-Spanish]
Clorotiazide
Clorotiazide [DCIT]
Clotride
component of Aldoclor
component of Diupres
CPD000058429
D00519
DB00880
Diupres
DIUPRES-250
DIUPRES-500
Diuresal
Diuril
Diuril (TN)
Diuril Boluses
Diuril Boluses, Veterinary
Diuril, Chlotride, Chlorothiazide
Diurilix
Diurite
Diutrid
DivK1c_000675
EINECS 200-404-9
EU-0100254
Flumen
HMS1568D04
HMS1920K15
HMS2091C18
HMS2095D04
HMS2232N22
HMS3259K15
HMS3260D10
HMS502B17
HSDB 3030
I06-2278
IDI1_000675
KBio1_000675
KBio2_000594
KBio2_003162
KBio2_005730
KBio3_001223
KBioGR_000780
KBioSS_000594
Lopac-C-4911
Lopac0_000254
LS-244
METHYLDOPA AND CHLOROTHIAZIDE
Minzil
Mixture Name
MLS000028398
NCGC00015242-01
NCGC00015242-02
NCGC00015242-03
NCGC00015242-04
NCGC00015242-05
NCGC00015242-06
NCGC00015242-07
NCGC00015242-08
NCGC00015242-09
NCGC00015242-10
NCGC00091042-01
NCGC00091042-02
NCGC00091042-03
NCGC00091042-04
NCGC00091042-05
Neo-dema
NINDS_000675
NSC 25693
NSC25693
Prestwick0_000251
Prestwick1_000251
Prestwick2_000251
Prestwick3_000251
Prestwick_56
S1641_Selleck
Salisan
Salunil
Saluretil
Saluric
SAM002554891
SK-Chlorothiazide
SMR000058429
SPBio_000288
SPBio_002281
SPECTRUM1500180
Spectrum2_000154
Spectrum3_000342
Spectrum4_000280
Spectrum5_001446
Spectrum_000134
ST5411290
Thiazide
UNII-77W477J15H
Urinex
Warduzide
WLN: T66 BSWM ENJ HG ISZW
Yadalan
ZINC03872055
ATC-Codes:
Side-Effects:
Side-EffectFrequency
headache0
diarrhea0
urticaria0
sialadenitis0
agitation0
exfoliative dermatitis0
aplastic anemia0
vertigo0
renal failure0
vomiting0
glycosuria0
spasm0
leukopenia0
hypotension0
photosensitivity0
alopecia0
anorexia0
nausea0
anaphylaxis0
pulmonary edema0
agranulocytosis0
hemolytic anemia0
constipation0
hematuria0
toxic epidermal necrolysis0
paresthesia0
pneumonia0
weakness0
jaundice0
erythema multiforme0
rash0
fever0
pancreatitis0
blurred vision0
dizziness0
hyperuricemia0
hyperglycemia0
impotence0
hypersensitivity0
stevens - johnson syndrome0
interstitial nephritis0
purpura0
vasculitis0

Target

show target details
Uniprot ID:CAH2_HUMAN
Synonyms:
CA-II
CAC
Carbonate dehydratase II
Carbonic anhydrase 2
Carbonic anhydrase C
Carbonic anhydrase II
EC-Numbers:4.2.1.1
Organism:Homo sapiens
Human
PDB IDs:12CA 1A42 1AM6 1AVN 1BCD 1BIC 1BN1 1BN3 1BN4 1BNM 1BNN 1BNQ 1BNT 1BNU 1BNV 1BNW 1BV3 1CA2 1CA3 1CAH 1CAI 1CAJ 1CAK 1CAL 1CAM 1CAN 1CAO 1CAY 1CAZ 1CCS 1CCT 1CCU 1CIL 1CIM 1CIN 1CNB 1CNC 1CNG 1CNH 1CNI 1CNJ 1CNK 1CNW 1CNX 1CNY 1CRA 1CVA 1CVB 1CVC 1CVD 1CVE 1CVF 1CVH 1DCA 1DCB 1EOU 1F2W 1FQL 1FQM 1FQN 1FQR 1FR4 1FR7 1FSN 1FSQ 1FSR 1G0E 1G0F 1G1D 1G3Z 1G45 1G46 1G48 1G4J 1G4O 1G52 1G53 1G54 1H4N 1H9N 1H9Q 1HCA 1HEA 1HEB 1HEC 1HED 1HVA 1I8Z 1I90 1I91 1I9L 1I9M 1I9N 1I9O 1I9P 1I9Q 1IF4 1IF5 1IF6 1IF7 1IF8 1IF9 1KWQ 1KWR 1LG5 1LG6 1LGD 1LUG 1LZV 1MOO 1MUA 1OKL 1OKM 1OKN 1OQ5 1RAY 1RAZ 1RZA 1RZB 1RZC 1RZD 1RZE 1T9N 1TB0 1TBT 1TE3 1TEQ 1TEU 1TG3 1TG9 1TH9 1THK 1TTM 1UGA 1UGB 1UGC 1UGD 1UGE 1UGF 1UGG 1XEG 1XEV 1XPZ 1XQ0 1YDA 1YDB 1YDC 1YDD 1YO0 1YO1 1YO2 1Z9Y 1ZE8 1ZFK 1ZFQ 1ZGE 1ZGF 1ZH9 1ZSA 1ZSB 1ZSC 2ABE 2AW1 2AX2 2CA2 2CBA 2CBB 2CBC 2CBD 2CBE 2EU2 2EU3 2EZ7 2F14 2FMG 2FMZ 2FNK 2FNM 2FNN 2FOQ 2FOS 2FOU 2FOV 2GD8 2GEH 2H15 2H4N 2HD6 2HKK 2HL4 2HNC 2HOC 2ILI 2NNG 2NNO 2NNS 2NNV 2NWO 2NWP 2NWY 2NWZ 2NXR 2NXS 2NXT 2O4Z 2OSF 2OSM 2POU 2POV 2POW 2Q1B 2Q1Q 2Q38 2QO8 2QOA 2QP6 2VVA 2VVB 3B4F 3BET 3BL0 3BL1 3C7P 3CA2 3CAJ 3CYU 3D8W 3D92 3D93 3D9Z 3DAZ 3DBU 3DC3 3DC9 3DCC 3DCS 3DCW 3DD0 3DD8 3DV7 3DVB 3DVC 3DVD 3EFT 3F4X 3FFP 3GZ0 3IBI 3IBL 3IBN 3IBU 4CA2 4CAC 5CA2 5CAC 6CA2 7CA2 8CA2 9CA2
Structure:
9CA2

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: