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Drug-Target Interaction

Drug

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PubChem ID:2477
Structure:
Synonyms:
36505-84-7
5-25-10-00059 (Beilstein Handbook Reference)
8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione
8-Azaspiro(4,5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)piperizinyl)butyl)-
8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-
8-Azaspiro[4.5]decane-7,9-dione, 8-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-
8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)-butyl]-8-aza-spiro[4.5]decane-7,9-dione
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dion
8-[4-(4-pyrimidin-2-ylpiperazin-1-yl)butyl]-8-azaspiro[4.5]decane-7,9-dione
AB00053432
Ansial
BAS 00928841
Biomol-NT_000108
BPBio1_000547
BPBio1_001403
BRN 0964904
BSPBio_000497
Buspar
Buspirona
Buspirona [INN-Spanish]
Buspirone
Buspirone (INN)
Buspirone HCL
Buspirone hydrochloride
Buspirone [INN:BAN]
Buspirone-MDTS
Buspironum
Buspironum [INN-Latin]
C06861
C13H21NO2.C9H14N4
CAS-33386-08-2
CHEBI:3223
CID2477
D07593
DB00490
DivK1c_000921
EINECS 253-072-2
Gen-Buspirone
Gen-Buspirone (TN)
IDI1_000921
KBio1_000921
KBio2_002236
KBio2_004804
KBio2_007372
KBioSS_002236
Lopac-B-7148
Lopac0_000223
LS-22723
MJ-9022-1
N-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide
NCGC00015162-01
NCGC00016820-01
NCGC00024905-01
NCGC00024905-02
NCGC00024905-03
NINDS_000921
Prestwick0_000369
Prestwick1_000369
Prestwick2_000369
Prestwick3_000369
SPBio_002418
Spectrum_001756
STOCK1S-11244
Tocris-0962
ATC-Codes:
Side-Effects:
Side-EffectFrequency
insomnia1.0
paresthesia1.0
weakness1.0
numbness1.0
nightmares1.0
nervousness1.0
nausea1.0
nasal congestion1.0
fatigue1.0
sweating1.0
tachycardia1.0
blurred vision1.0
sore throat1.0
muscle aches1.0
lightheadedness1.0
dry mouth1.0
vomiting1.0
tremor1.0
tinnitus1.0
skin rash1.0
chest pain1.0
headache1.0
drowsiness1.0
constipation1.0
diarrhea1.0
confusion1.0
dizziness0.667
anorexia0.01
weight loss0.01
chills0.01
hypersalivation0.01
spasms0.01
arthralgia0.01
malaise0.01
menstrual irregularity0.01
dry skin0.01
blisters0.01
rectal bleeding0.01
shortness of breath0.01
hypertension0.01
hypotension0.01
weight gain0.01
fever0.01
flatulence0.01
urinary frequency0.01
irritable colon0.01
hair loss0.01
easy bruising0.01
breakthrough bleeding0.01
flushing0.01
muscle cramps0.01
edema0.009999999
pruritus0.009999999
seizures0.0082
hallucinations0.0082
syncope0.0082
alcohol abuse0.0010
photophobia0.0010
restlessness0.0010
amenorrhea0.0010
cerebrovascular accident0.0010
cardiomyopathy0.0010
acne0.0010
parkinsonism0.0010
allergic reactions0.0010
galactorrhea0.0010
bradycardia0.0010
angioedema0.0010
stiff neck0.0010
urinary retention0.0010
enuresis0.0010
myocardial infarction0.0010
serotonin syndrome0.0010
leukopenia0.0010
flu0.0010
hiccups0.0010
congestive heart failure0.0010
eosinophilia0.0010
epistaxis0.0010
ecchymosis0.0010
dyskinesias0.0010
nocturia0.0010
ataxias0.0010
impotence0.0010
vertigo0.0010
urticaria0.0010
erythema0.0010
cold intolerance0.0010
thrombocytopenia0.0010
restless leg syndrome0.0010
psychosis0.0010
thinking abnormal0
excitement0
feeling high0
depersonalization0
emotional lability0
euphoria0
dysphoria0
stupor0
hemorrhage0
palpitations0
urinary hesitancy0
pelvic inflammatory disease0
dysuria0
conjunctivitis0
aphonia0
eye pain0
muscle weakness0
anger0

Target

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Uniprot ID:DRD2_HUMAN
Synonyms:
D(2) dopamine receptor
Dopamine D2 receptor
EC-Numbers:-
Organism:Homo sapiens
Human
PDB IDs:1I15 2HLB
Structure:
2HLB

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
----
13---
90.0---
1000---

References: