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Drug-Target Interaction

Drug

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PubChem ID:244
Structure:
Synonyms:
(Hydroxymethyl)benzene
.alpha.-Hydroxytoluene
.alpha.-Toluenol
100-51-6
108006_ALDRICH
108006_SIAL
13160_FLUKA
13160_SIAL
1336-27-2
185532-71-2
24122_RIEDEL
24122_SIAL
305197_ALDRICH
305197_SIAL
34460_FLUKA
34460_RIEDEL
3762963D-6C2A-4BFF-AD94-3180E51BCA68
4-06-00-02222 (Beilstein Handbook Reference)
402834_SIAL
442481_SUPELCO
AB1002552
AC1L18SY
AC1Q7C20
AG-D-05803
AI3-01680
AIDS-009274
AIDS009274
AKOS000119907
Alcohol bencilico
Alcohol bencilico [INN-Spanish]
Alcohol, Benzyl
alcoholum benzylicum
Alcoholum benzylicum [INN-Latin]
Alcool benzilico
Alcool benzilico [DCIT]
Alcool benzylique
Alcool benzylique [INN-French]
alpha-hydroxytoluene
alpha-Toluenol
aplha-Hydroxytoluene
Aromatic alcohol
Aromatic primary alcohol
B2378
BB_SC-7027
Benzal alcohol
Benzencarbinol
Benzene Carbinol
Benzenecarbinol
benzenemethanol
Benzoyl alcohol
benzyl alcohol
Benzyl alcohol (JP15/NF)
Benzyl alcohol (JP15/NF/INN)
Benzyl alcohol (JP16/NF/INN)
Benzyl alcohol (natural)
Benzyl alcohol [USAN:INN:JAN]
BENZYL ALCOHOL, ACS
BENZYL ALCOHOL, U.S.P./N.F.
Benzyl Alcohole
BENZYL-ALCOHOL
benzylalcohol
Benzylalkohol
benzylic alcohol
Benzylicum
BIDD:ER0248
bmse000407
BRN 0878307
Butyl ether
C00556
c0278
C03485
C7H8O
Caswell No. 081F
CCRIS 2081
CHEBI:17987
CHEMBL720
D00077
D019905
Dibutyl ether
EINECS 202-859-9
EPA Pesticide Chemical Code 009502
Euxyl K 100
FEMA No. 2137
HMS3264B16
HSDB 46
hydroxymethylbenzene
Hydroxytoluene
I01-4406
Itch-X
Jsp000133
LS-307
MBN
Methanol, phenyl-
Mixture Name
MolPort-001-783-216
NCGC00091865-01
NCGC00091865-02
NCGC00091865-03
NCGC00091865-04
nchem.167-comp3
nchem.651-comp3i
nchem.932-comp19
NCI-C06111
NSC 8044
NSC8044
OBZ
PENTADEOTEROBENZYL ALCOHOL
Phenolcarbinol
Phenyl Methanol
Phenyl-Methanol
phenylcarbinol
Phenylcarbinolum
phenylmethanol
Phenylmethyl alcohol
TOLUENE,ALPHA-HYDROXY
Ulesfia (TN)
UNII-LKG8494WBH
W213705_ALDRICH
W213713_ALDRICH
WLN: Q1R
ZINC00895302

Target

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Uniprot ID:Q7M053_RAT
Synonyms:
Aldehyde dehydrogenase
EC-Numbers:1.-.-.-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

1685418
Benzyl alcohol adverse effects in the rat: implications for toxicity as a preservative in parentral injectable solutions.. F S Messiha (1991) Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology display abstract
1. Short-term intake of a 2% benzyl alcohol in the rat drinking fluid resulted in sex-dependent inhibition of hepatic alcohol dehydrogenase. 2. Benzyl alcohol intake also inhibited female but not male mitochondrial aldehyde dehydrogenase isoenzymes with the apparent low and high Km. 3. The benzyl alcohol inhibition kinetics were found non-competitive with the major differences in Vmax being confined to the cytoplasmic enzymes. 4. The velocity of the enzymatic reaction was greater for the substrate benzaldehyde than benzyl alcohol. 5. The results suggest sex-dependent hepatic alcohol dehydrogenase-substrate competition between benzyl alcohol and ethanol which may precipitate adverse metabolic interaction particularly in the susceptible female subject. 6. Modulation of the activity of this enzyme by benzyl alcohol may contribute to its toxicity as preservative in parentral injectable solutions.