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Drug-Target Interaction

Drug

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PubChem ID:24360
Structure:
Synonyms:
"4-ethyl-4-hydroxy-1h-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)dione"
()-camptothecin
()-camptothecine
(+)-Camptothecin
(+)-Camptothecine
(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14
(4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(s)-()-camptothecin
(S)-(+)-Camptothecin
(S)-4-ethyl-4-hydroxy-1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
(S)-Camptothecin
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-
1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
1H-Pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-
20(S)-Camptothecin
20(S)-Camptothecine
21,22-Secocamptothecin-21-oic acid lactone
25387-67-1 (SODIUM SALT)
4(S)-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14 (4H,12H)-dione
4-ethyl-4-hydroxy-1,12-dihydro-4h-2-oxa-6,12a-diaza- Dibenzo[b,h]fluorene-3,13-dione
4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZO[B,H]FLUORENE-3,13-DIONE
4-Ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
4-Ethyl-4-hydroxy-1H-pyrano-[3[,4[:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
4-Ethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
7689-03-4
AI3-62475
AIDS-001995
AIDS001995
BB_NC-0996
Bio1_000400
Bio1_000889
Bio1_001378
BPBio1_000175
BRN 0631069
BSPBio_000159
BSPBio_002586
C01897
C9911_SIGMA
Camptothecin
Camptothecin derivative
Camptothecin, Camptotheca acuminata
Camptothecine
Camptothecine (8CI)
Camptothecine (S,+)
CAS-2114454
CCRIS 8162
CHEBI:27656
CPT
d-Camptothecin
DB04690
DivK1c_000826
DivK1c_006808
EHD
EU-0100341
IDI1_000826
KBio1_000826
KBio1_001752
KBio2_000779
KBio2_003347
KBio2_005915
KBio3_002086
KBioGR_001036
KBioSS_000779
KBioSS_002283
Lopac-C-9911
Lopac0_000341
MLS000766223
NCGC00015290-01
NCGC00016994-01
NCGC00024997-01
NCGC00024997-02
NCGC00024997-03
NCGC00024997-04
NCGC00024997-05
NCGC00024997-06
NCGC00178592-01
NCGC00178592-02
NCI60_042105
NINDS_000826
NSC 100880
NSC 94600
NSC94600
Prestwick0_000200
Prestwick1_000200
Prestwick2_000200
Prestwick3_000200
Prestwick_102
SDCCGMLS-0066688.P001
SMR000445686
SPBio_000746
SPBio_002080
SpecPlus_000712
SPECTRUM1502232
Spectrum2_000903
Spectrum3_001203
Spectrum4_000738
Spectrum5_001126
Spectrum_000299
Tocris-1100
ZINC00105309

Target

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Uniprot ID:TOP2A_HUMAN
Synonyms:
DNA topoisomerase 2-alpha
DNA topoisomerase II, alpha isozyme
EC-Numbers:5.99.1.3
Organism:Homo sapiens
Human
PDB IDs:1LWZ 1ZXM 1ZXN
Structure:
1ZXN

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
-->300000-

References: