Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:237
Structure:
Synonyms:
1,4-Pentanediamine, N4-(6-chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-
130-42-7
130-42-7 (mono-hydrochloride)
2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine
3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine
316-05-2
316-05-2 (dimesylate)
4-N-(6-chloro-2-methoxyacridin-9-yl)-1-N,1-N-diethylpentane-1,4-diamine
6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine
6151-30-0
6151-30-0 (di-hydrochloride, di-hydrate)
6151-30-0 (DIHYDROCHLORIDE DIHYDRATE)
66777-81-9
69-05-6
69-05-6 (di-hydrochloride)
69-05-6 (DIHYDROCHLORIDE)
78901-94-7
78901-94-7 (monoacetate)
83-89-6
AB00053540
AC1L18SD
Acirchine
Acrichine
Acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxy-
Acridine, 6-chloro-9-[[4-(diethylamino)-1-methylbutyl]amino]-2-methoxy-
Acrinamine
Acriquine
AI3-04467
AIDS-002327
AIDS002327
AKOS000541535
Akrichin
Antimalarina
Atabrine
atebrin
Atebrine
BAS 00439963
BPBio1_000348
BRD-A45889380-336-03-4
BSPBio_000316
BSPBio_002112
C07339
CCG-205050
CCRIS 8633
CHEBI:8711
CHEMBL7568
Chinacrin
cMAP_000067
D08179
DB01103
Dial
DivK1c_000101
EINECS 201-508-7
Erion
Erion Hydrochloride
GNF-PF-5448
Haffkinine
HMS2090L03
HSDB 3253
IDI1_000101
Italchin
Italchine
KBio1_000101
KBio2_001409
KBio2_002507
KBio2_003977
KBio2_005075
KBio2_006545
KBio2_007643
KBio3_001612
KBio3_002985
KBioGR_001011
KBioGR_002507
KBioSS_001409
KBioSS_002515
Lopac0_000970
LS-14293
Malaricida
Mecryl
Mepacrina
Mepacrina [INN-Spanish]
Mepacrine
Mepacrine (INN)
Mepacrine [INN:BAN]
Mepacrinum
Mepacrinum [INN-Latin]
Methoquine
Metochin
MS-1557
N'-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine
N'-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine dihydrochloride
N'-(6-chloro-2-methoxyacridin-9-yl)-N,N-diethylpentane-1,4-diamine
N(4)-(6-chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine
N*4*-(6-Chloro-2-methoxy-acridin-9-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine
N4-(6-Chloro-2-methoxy-9-acridinyl)-N1,N1-diethyl-1,4-pentanediamine
NCGC00015874-02
NCGC00015874-03
NCGC00015874-04
NCGC00162300-01
nchembio.215-comp6
nchembio873-comp30
NCI60_000926
NINDS_000101
N~4~-[6-chloro-2-(methyloxy)acridin-9-yl]-N~1~,N~1~-diethylpentane-1,4-diamine
Palacrin
Palusan
Pentilen
Prestwick0_000318
Prestwick1_000318
Prestwick2_000318
Prestwick3_000318
Quinacrin
Quinacrine
Quinacrine Dihydrochloride
Quinactine
RP-866 (Dihydrochloride dihydrate)
SN-390 (Dihydrochloride dihydrate)
SPBio_000676
SPBio_002535
Spectrum2_000888
Spectrum3_000606
Spectrum4_000496
Spectrum5_001405
Spectrum_000929
St 439
STL061087
ATC-Codes:

Target

show target details
Uniprot ID:PA2GA_CAVPO
Synonyms:
GIIC sPLA2
Group IIA phospholipase A2
Phosphatidylcholine 2-acylhydrolase
Phospholipase A2, membrane associated
EC-Numbers:3.1.1.4
Organism:Cavia porcellus
Guinea pig
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

6653661
Inhibition of agonist-induced degradation of muscarinic cholinergic receptor by quinacrine and tetracaine--possible involvement of phospholipase A2 in receptor degradation.. H Higuchi; S Uchida; K Matsumoto; H Yoshida (1983) European journal of pharmacology display abstract
Muscarinic cholinergic receptors (mAChR) are degraded on the addition of agonists through energy- and temperature-dependent processes, probably with clustering and endocytosis. Pretreatment of guinea-pig vas deferens with 0.5 mM quinacrine or 5 mM tetracaine, phospholipase A2 (PLase A2) inhibitors, inhibited the ACh-induced degradation of mAChR in the smooth muscle and kept mAChR on the surface membrane, while cocaine and procaine were not effective. On pretreatment with quinacrine or tetracaine the PLase A2 activity in the smooth muscle decreased continuously during culture without change in the contractile response of the tissue. Pretreatment with cocaine and procaine which had no significant effect on the down regulation of mAChR did not inhibit PLase A2 activity. However, activation of PLase A2 by long-term culture of the muscle with ACh and formation of endogenous inhibitor of PLase A2 were not observed under our experimental conditions. The participation of PLase A2 in the agonist-induced degradation of mAChR is discussed in the light of these findings.