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Drug-Target Interaction

Drug

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PubChem ID:22576
Structure:
Synonyms:
1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-,
1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
1-Propanamine, 3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-, hydrochloride
10,11.delta.-Amitriptyline hydrochloride
10,11delta-Amitriptyline hydrochloride
3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium chloride
303-53-7
5-(3-Dimethylaminopropylidene)-5H-dibenzo-(a,d)cycloheptene hydrochloride
5-(3-Dimethylaminopropylidene)dibenzo[a,e]cycloheptatriene hydrochloride
5-[3-(Dimethylamino)propylidene]-5H-dibenzo-[a,d]cycloheptene hydrochloride
5H-Dibenzo(a,d)cycloheptene-delta(sup 5)-gamma-propylamine, N,N-dimethyl-, hydrochloride
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, N,N-dimethyl-, hydrochloride
5H-Dibenzo(a,d)cycloheptene-delta5,gamma-propylamine, N,N-dimethyl-, hydrochloride (8CI)
5H-Dibenzo[a,d]cycloheptene-.delta.(sup5)-.gamma.-propylamine, N,N-dimethyl-, hydrochloride
5H-Dibenzo[a,d]cycloheptene-.DELTA.5,.gamma.-propylamine, N,N-dimethyl-, hydrochloride
6202-23-9
Amrix
C20H21N.HCl
C4542_SIGMA
CHEBI:3997
Cloben
Cyben
CYCLOBENZAPRINE HCL
Cyclobenzaprine hydrochloride
Cyclobenzaprine hydrochloride (USP)
Cyclobenzaprine hydrochloride [USAN]
Cycloflex
D00772
EINECS 228-264-4
EU-0100303
EUR-1002
Flexeril
Flexeril (TN)
Flexeril hydrochloride
Flexiban
Lisseril
LS-60768
MK 130 hydrochloride
MK-130 HCl
MLS002153815
N,N-Dimethyl-5H-dibenzo(a,d)cycloheptene-delta(sup 5,gamma)-propylamine hydrochloride
N,N-Dimethyl-5H-dibenzo[a,d]cycloheptene-.delta.(sup5,.gamma.)-propylamine hydrochloride
N,N-Dimethyl-5H-dibenzo[a,d]cycloheptene-.delta.,5.gamma.-propylamine, hydrochloride
NCGC00093752-01
NCGC00095017-01
NCGC00095017-02
NCGC00095017-03
NCGC00095017-04
Novo-Cycloprine
NSC 169900
NSC 173379
NSC 78206
NSC169900
NSC173379
Prestwick_790
Proheptatrien monohydrochloride
Proheptatriene hydrochloride
Proheptatriene monohydrochloride
SMR000326702
SPECTRUM1503207
Tensodox
WLN: L C676 BHJ B3N1&1 &GH
Side-Effects:
Side-EffectFrequency
tachycardia0.40060002
drowsiness0.27811113
weakness0.25075004
blurred vision0.25075004
paresthesia0.25075
dyspepsia0.25075
nausea0.25075
insomnia0.25075
dry mouth0.20420457
fatigue0.09906666
dizziness0.090892844
headache0.033666667
sweating0.0010
stomatitis0.0010
seizures0.0010
stroke0.0010
purpura0.0010
psychosis0.0010
pruritus0.0010
peripheral neuropathy0.0010
paralytic ileus0.0010
palpitation0.0010
pain0.0010
nervousness0.0010
myocardial infarction0.0010
swelling0.0010
syncope0.0010
urinary frequency0.0010
abnormal gait0.0010
palsy0.0010
testicular swelling0.0010
galactorrhea0.0010
allergic reaction0.0010
myalgia0.0010
malaise0.0010
agitation0.0010
urinary retention0.0010
weight gain0.0010
vomiting0.0010
vertigo0.0010
urticaria0.0010
tremors0.0010
tinnitus0.0010
thrombocytopenia0.0010
paranoia0.0010
leukopenia0.0010
eosinophilia0.0010
edema0.0010
dyspnea0.0010
abdominal pain0.0010
dysarthria0.0010
anaphylaxis0.0010
diplopia0.0010
diarrhea0.0010
angioedema0.0010
convulsions0.0010
confusion0.0010
coated tongue0.0010
chest pain0.0010
anxiety0.0010
arrhythmia0.0010
anorexia0.0010
ataxia0.0010
constipation0.0010
rash0.0010
jaundice0.0010
alopecia0.0010
inappropriate adh syndrome0.0010
impotence0.0010
hypotension0.0010
breast enlargement0.0010
asthenia0.0010
hypertension0.0010
hypersensitivity0.0010
flatulence0.0010
gastritis0.0010
gynecomastia0.0010
hallucinations0.0010
heart block0.0010
hepatitis0.0010
depressed mood0
agranulocytosis0
thinking abnormal0
acne0
excitement0
disturbance in attention0
nightmares0
numbness0
pharyngitis0
upper respiratory tract infection0
delusions0
decreased libido0
euphoria0
regurgitation0
irritability0

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: