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Drug-Target Interaction

Drug

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PubChem ID:2214
Structure:
Synonyms:
1-(4-hydroxy-3-methoxyphenyl)-ethanone
1-(4-hydroxy-3-methoxyphenyl)ethan-1-one
1-(4-Hydroxy-3-methoxyphenyl)ethanone
3-Methoxy-4-hydroxyacetophenone
3-Metoksy-4-hydroksyacetofenon
3-Metoksy-4-hydroksyacetofenon [Polish]
4'-Hydroxy-3'-methoxyacetophenone
4-08-00-01814 (Beilstein Handbook Reference)
4-Acetyl-2-methoxyphenol
4-Hydroxy-3-methoxyacetophenone
4-Hydroxy-3-methoxyphenyl methyl ketone
498-02-2
A10809_ALDRICH
AA-504/20839006
AB1003774
AC-11656
AC1L1D6F
AC1Q46A5
AC1Q7AD6
Acetoguaiacon
Acetoguaiacone
Acetophenone, 4'-hydroxy-3'-methoxy-
ACETOPHENONE,4-HYDROXY,3-METHOXY ACETOVANILLON
ACETOPHENONE,4-HYDROXY,3-METHOXY ACETOVANILLON
Acetovanillon
Acetovanillone
Acetovanilone
Acetovanyllon
AI3-15892
AKOS000120562
Apocynin
Apocynine
AR-1H7512
BB_NC-2250
bmse000584
bmse010031
BRN 0637373
C056165
C11380
C9H10O3
CCRIS 7285
CHEBI:2781
CHEMBL346919
EINECS 207-854-5
Ethanone, 1-(4-hydroxy-3-methoxyphenyl)-
H0261
I01-7005
LS-13569
MLS001304972
MolPort-000-000-274
NCGC00247065-01
nchembio.83-comp20
NSC 209524
NSC209524
NSC2146
SBB008060
SMR000752909
W508454_ALDRICH
WLN: 1VR DQ CO1
ZINC00162515

Target

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Uniprot ID:CASP3_RAT
Synonyms:
Apopain
CASP-3
Caspase-3
CPP-32
Cysteine protease CPP32
IRP
LICE
SCA-1
SREBP cleavage activity 1
Yama protein
EC-Numbers:3.4.22.56
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

17615545
Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity.. Yuta Saito; Pete Geisen; Abhineet Uppal; M Elizabeth Hartnett (2007) Molecular vision display abstract
PURPOSE: To study the mechanisms of action of the antioxidants, n-acetylcysteine (NAC), and the nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase oxidase inhibitor, apocynin, on intravitreous neovascularization (IVNV), and retinal avascularity in a rat model of retinopathy of prematurity (ROP). METHODS: Newborn rats exposed to oxygen-induced retinopathy underwent intraperitoneal (IP) injections of NAC (150 mg/kg) at post-natal day (p)2, p6, p10 (early NAC-treated), or p12 through p17 (late NAC-treated), apocynin (10 mg/kg) from p12 through p17, or phosphate buffered saline (PBS; controls). Lipid hydroperoxide (LHP) was measured in early NAC-treated oxygen-induced retinopathy (OIR) at p7, p14 and p18. Pups were placed in room air at p14. At p18, retinal flat mounts were scored for IVNV and avascular/total retinal area, or retinas were assayed for cleaved caspase-3 and vascular endothelial growth factor (VEGF) protein. In non-injected OIR pups, retinas were assayed for gp91(phox). Cryosections were stained with isolectin B4, cleaved caspase-3, CD68, CD31, gp91(phox), neuron-glial antigen 2 (NG-2), or anti-glial fibrillary acidic protein (GFAP) and visualized with confocal microscopy. RESULTS: LHP increased over time in retinas from OIR exposed pups in association with IVNV. Early NAC-treated retinas had significantly reduced LHP compared to PBS-control at p18 (p