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Drug-Target Interaction

Drug

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PubChem ID:2187
Structure:
Synonyms:
.alpha.,alpha.,.alpha.',.alpha.'-tetramethyl-5(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
1,3-Benzenediacetonitrile,
1,3-benzenediacetonitrile, a, a, a', a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)
1,3-Benzenediacetonitrile, alpha,alpha,alpha',alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
1,3-Benzenediacetonitrile,.alpha.,alpha.,alpha.',.alpha.'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
120511-73-1
2,2'-(5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene)bis(2-methylpropionitrile)
2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)benzene-1,3-diyl]bis(2-methylpropanenitrile)
2-[3-(2-cyanopropan-2-yl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropanenitrile
alpha,alpha,alpha',alpha'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-m-benzenediacetonitrile
Ambap4000
anastrazole
Anastrole
Anastrozol
Anastrozole
Anastrozole (JAN/USAN/INN)
Anastrozole [USAN:BAN:INN]
Anastrozole [USAN:INN:BAN]
Arimidex
Arimidex (TN)
Arimidex (Zeneca)
Arimidex, Anastrozole
Astra brand of anastrozole
AstraZeneca brand of anastrozole
C08159
C090450
C17H19N5
CHEBI:2704
CPD000466301
D00960
DB01217
HSDB 7462
ICI D1033
ICI-D 1033
ICI-D1033
LS-29563
MLS000759396
MLS001424217
NCGC00164619-01
NSC719344
SAM001246525
SMR000466301
ZD 1033
ZD-1033
ZD1033
Zeneca brand of anastrozole
Zeneca ZD 1033
ZINC00000941
ATC-Codes:
Side-Effects:
Side-EffectFrequency
hot flashes0.1200115
nausea0.117537
headache0.10321099
flushes0.102132395
pain0.08744734
asthenia0.07411274
dyspnea0.067453034
cough0.052713405
diarrhea0.052713405
pharyngitis0.051854867
vomiting0.049823526
anorexia0.04897937
constipation0.047624335
edema0.047085024
back pain0.0431122
dizziness0.036949735
peripheral edema0.03520025
dry mouth0.034322433
abdominal pain0.031903226
chest pain0.03119725
pelvic pain0.031135198
paresthesia0.027194275
bone pain0.022295164
weight gain0.016748872
rash0.015528439
tumor0.0105481
sweating0.009487433
vaginal hemorrhage0.0061158235
cerebrovascular accidents0.0010
stevens - johnson syndrome0.0010
sinusitis0.0010
rhinitis0.0010
pruritus0.0010
elevated serum cholesterol0.0010
breast cancer0.0010
insomnia0.0010
breast neoplasm0.0010
allergic reactions0.0010
endometrial cancer0.0010
myalgia0.0010
urinary tract infection0.0010
cataracts0.0010
weight loss0.0010
myocardial ischemia0.0010
alkaline phosphatase increased0.0010
vulvovaginitis0.0010
sgot increased0.0010
vaginal discharge0.0010
vaginitis0.0010
malaise0.0010
urticaria0.0010
thrombophlebitis0.0010
hair thinning0.0010
somnolence0.0010
cyst0.0010
coronary artery disorder0.0010
confusion0.0010
neck pain0.0010
carpal tunnel0.0010
bronchitis0.0010
arthritis0.0010
joint pain0.0010
anxiety0.0010
angioedema0.0010
angina pectoris0.0010
anemia0.0010
anaphylaxis0.0010
dyspepsia0.0010
erythema multiforme0.0010
fatigue0.0010
osteoporosis0.0010
nervousness0.0010
myocardial infarct0.0010
breast pain0.0010
lymphoedema0.0010
leukopenia0.0010
joint disorder0.0010
flu syndrome0.0010
infection0.0010
fever0.0010
pathological fracture0.0010
bleeding0.0010
hepatitis0.0010
hypercholesterolemia0.0010
hypertension0.0010
cerebral infarction0
trigger finger0
ischemia0
constitutional symptoms0
cerebral ischemia0
pulmonary embolism0
retinal vein thrombosis0
elevated liver function tests0
deep vein thrombosis0
cancer0
neuropathy0

Target

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Uniprot ID:CP2CJ_HUMAN
Synonyms:
(R)-limonene 6-monooxygenase
(S)-limonene 6-monooxygenase
(S)-limonene 7-monooxygenase
CYPIIC17
CYPIIC19
Cytochrome P450 2C19
Mephenytoin 4-hydroxylase
P450-11A
P450-254C
EC-Numbers:1.14.13.48
1.14.13.49
1.14.13.80
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References: