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Drug-Target Interaction

Drug

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PubChem ID:2182
Structure:
Synonyms:
6,7-Dichlor-1,5-dihydroimidazo(2,1-b)chinazolin-2(3H)-on
6,7-Dichloro-1,5-dihydroimidazo(2,1-b)quinazolin-2(3H)-one
6,7-dichloro-1,5-dihydroimidazo[2,1-]quinazolin-2(3H)-one
6,7-dichloro-5,10-dihydro-3H-imidazo[2,1-b]quinazolin-2-one
68475-42-3
AC-3401
AC1L1D3U
Anagrelida
Anagrelida [INN-Spanish]
Anagrelide
Anagrelide (INN/BAN)
Anagrelide HCL
Anagrelide Hydrochloride
Anagrelide [BAN:INN]
Anagrelide [INN:BAN]
Anagrelidum
Anagrelidum [INN-Latin]
BIDD:GT0711
BL 416201
BL-4162A
BRN 0619582
C10H7Cl2N3O
CHEBI:142290
CHEMBL760
D07455
DB00261
HMS2089D21
HSDB 7325
I14-11970
Imidazo(2,1-b)quinazolin-2(3H)-one, 6,7-dichloro-1,5-dihydro-
LS-80464
NCGC00161408-01
NCGC00161408-02
NCGC00247665-01
UNII-K9X45X0051
ZINC03871541
ATC-Codes:
Side-Effects:
Side-EffectFrequency
palpitations0.261
diarrhea0.257
asthenia0.231
edema0.206
nausea0.171
abdominal pain0.164
dizziness0.154
pain0.15
dyspnea0.119
flatulence0.102
vomiting0.097
fever0.089
peripheral edema0.085
rash0.083
urticaria0.083
chest pain0.078
anorexia0.077
tachycardia0.075
pharyngitis0.068
malaise0.064
cough0.063
back pain0.059
paresthesia0.059
pruritus0.055
dyspepsia0.052
eosinophilic pneumonia0.0010
interstitial lung diseases0.0010
interstitial pneumonitis0.0010
allergic alveolitis0.0010
pulmonary hypertension0
dysphagia0
ecchymosis0
migraine0
elevated liver enzymes0
pericardial effusion0
somnolence0
infection0
rhinitis0
pericarditis0
urinary frequency0
complete heart block0
constipation0
cardiomyopathy0
hematuria0
cardiomegaly0
heart failure0
congestive heart failure0
ulcerative stomatitis0
nervousness0
influenza0
amnesia0
constitutional symptoms0
angina pectoris0
insomnia0
myalgia0
essential thrombocythemia0
arthralgia0
arthritis0
hypotension0
melena0
headache0
postural hypotension0
abnormal vision0
pancreatitis0
neck pain0
epistaxis0
thrombocytopenia0
hemorrhage0
laboratory test abnormal0
dehydration0
chronic myeloid leukemia0
sweating0
leg cramps0
gastritis0
anemia0
renal insufficiency0
arrhythmia0
cancer0
lymphadenopathy0
syncope0
alopecia0
photosensitivity0
atrial fibrillation0
dry mouth0
renal failure0
diplopia0
myocardial infarction0
cellulitis0
confusion0
urinary tract infection0
polycythemia vera0
urinary incontinence0
hypertension0
bone pain0
duodenal ulcer0
pleural effusion0
tinnitus0
dysuria0
seizures0
gastrointestinal hemorrhage0
fibrosis0
bronchitis0
pulmonary fibrosis0
weight loss0
weight gain0
asthma0
nocturia0
elevated liver function tests0
cerebrovascular accident0
conjunctivitis0
pneumonia0
sinusitis0
blurred vision0
chills0
amblyopia0
skin ulcer0
eructation0

Target

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Uniprot ID:PDE2A_HUMAN
Synonyms:
cGMP-dependent 3',5'-cyclic phosphodiesterase
CGS-PDE
cGSPDE
Cyclic GMP-stimulated phosphodiesterase
EC-Numbers:3.1.4.17
Organism:Homo sapiens
Human
PDB IDs:1Z1L
Structure:
1Z1L

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
--34000-

References: