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Drug-Target Interaction

Drug

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PubChem ID:216239
Structure:
Synonyms:
2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-
284461-73-0
4-(4-((((4-Chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl-2-pyridinecarboxamide
4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic acid methyamide-4-methylbenzenesulfonate
4-(4-{3-(4-Chloro-3-(trifluoromethyl)phenyl)ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide
4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methyl-pyridine-2-carboxamide
4-[4-[[4-chloro-3-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-N-methylpyridine-2-carboxamide
4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE
BAX
BAY 43-9006
BAY 439006
BAY-43-0006
BAY-43-9006
BAY-54-9085
CHEBI:50924
DB00398
K00597a
LS-186067
LS-187021
LS-187788
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyri
N-(4-Chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-methylcarbamoyl)-4-pyridyloxy)phenyl)urea
NCGC00167488-01
nchembio.117-comp17
Nexavar
NSC-724772
Sorafenib
Sorafenib tosylate
Sorafenib [INN]
sorafenibum
STOCK6S-50043
ZINC01493878
ATC-Codes:
Side-Effects:
Side-EffectFrequency
weight loss0
influenza0
mediastinal disorders0
cholangitis0
heart disease0
hypothyroidism0
abdominal pain upper0
exfoliative dermatitis0
dyspepsia0
peripheral edema0
puncture0
breast disorders0
acute renal failure0
keratoacanthomas0
rash0
atopic dermatitis0
constipation0
folliculitis0
hematuria0
heart failure0
congestive heart failure0
stomatitis0
dry skin0
ulcer0
vascular disorders0
thrombocythemia0
infection0
gynecomastia0
amylase increased0
abdominal pain0
cerebral hemorrhage0
dyspnea0
vomiting0
neuropathy0
myalgia0
loss of consciousness0
arthralgia0
hypotension0
headache0
dehydration0
neutropenia0
connective tissue disorders0
erythema multiforme0
hematoma0
constitutional symptoms0
tachycardia0
pancreatitis0
proteinuria0
interstitial nephritis0
epistaxis0
thrombocytopenia0
hemorrhage0
mood alteration0
malaise0
gastritis0
dry mouth0
anemia0
jaundice0
dysphagia0
arrhythmia0
cancer0
gastroesophageal reflux0
gum hemorrhage0
pain0
pain in limb0
nausea0
transient ischemic attack0
urticaria0
erythema0
cholecystitis0
rectal hemorrhage0
esophageal varices0
fever0
acne0
hematemesis0
nephrotic syndrome0
hypertension0
lymphopenia0
pruritus0
syncope0
eczema0
renal failure0
hoarseness0
fatigue0
rhinorrhea0
endocrine disorders0
asthenia0
diarrhea0
tinnitus0
myocardial ischemia0
intracranial hemorrhage0
hemoptysis0
ascites0
dizziness0
edema0
menorrhagia0
anorexia0
hyponatremia0
hypophosphatemia0
pleural effusion0
flushing0
tumor0
leukopenia0
alopecia0
cough0
hypersensitivity0
glossodynia0

Target

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Uniprot ID:MET_HUMAN
Synonyms:
c-Met
Hepatocyte growth factor receptor
HGF receptor
HGF/SF receptor
Met proto-oncogene tyrosine kinase
Scatter factor receptor
SF receptor
EC-Numbers:2.7.10.1
Organism:Homo sapiens
Human
PDB IDs:1FYR 1R0P 1R1W 1SHY 1SSL 1UX3 2G15 2RFN 2RFS 2UZX 2UZY 2WD1 2WGJ 3BUX 3CE3 3CTH 3CTJ 3EFJ 3EFK 3F66 3F82
Structure:
3F82

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: