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Drug-Target Interaction

Drug

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PubChem ID:2140
Structure:
Synonyms:
(Diacetyldiamine)triiodobenzoate
117-96-4
2,4,6-Triiodo-3,5-diacetamidobenzoic acid
3, 5-Diacetamido-2,4,6-triiodobenzoic
3, 5-Diacetamido-2,4,6-triiodobenzoic acid, sodium salt
3,5-Bis(acetamido)-2,4,6-triiodobenzoic Acid
3,5-Bis(acetylamino)-2,4,6-triiodobenzoic acid
3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid
3,5-Diacetamido-2,4,6-triiodobenzoate
3,5-Diacetamido-2,4,6-triiodobenzoic acid
4-14-00-01308 (Beilstein Handbook Reference)
737-31-5 (SODIUM SALT)
AC-4695
AC1L1D0C
Acide amidotrizoique
Acidum amidotrizoicum
Acidum diacetylaminotrijodbenzoicum
AIDS-155966
AIDS155966
AKOS001073646
Amidotrizoate
Amidotrizoate (*sodium salt*)
AmiDOTrizoic acid
amidotrizoic acid (anhydrous)
Amidotrizoic acid (JP15)
Amidotrizoic acid (JP16)
Amidotrzoique (acide)
benzoate
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, monosodium salt
Benzoic acid, 3,5-diacetamido-2,4, 6-triiodo-, sodium salt
Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-
Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt
BRN 2225144
CHEBI:53691
CHEMBL1201220
Conray 35
D02240
D1462
D9268_SIGMA
D9809_SIAL
DB00271
Diat
DIAT [German]
Diatriazoate
Diatrizoate
Diatrizoate sodium
Diatrizoate sodium salt
Diatrizoesaeure
Diatrizoesaure
Diatrizoesaure [German]
Diatrizoic acid
diatrizoic acid (anhydrous)
Diatrizoic acid (USP)
Diatrizoic acid dihydrate
Diatrizoic acid sodium salt
Diatrizoic acid [USAN:BAN]
EINECS 204-223-6
G 2-75
Gastrografin
HMS2094A11
HSDB 4042
Hypaque
Hypaque 50
Hypaque sodium
Iothalamate
LS-36713
MD-50
Meglumine diatrizoate
Methalamic acid
Ml 216
NCGC00021123-01
NCGC00021123-02
NSC 262168
NSC262168
NSC61815
NSC61815 (SODIUM SALT)
Odiston
Renografin 76
S 17
Sodium (diacetyldiamine)triiodobenzoate
Sodium 3,5-diacetamido-2,4,6-triiodobenzoate
Sodium amidotrizoate
Sodium diatrizoate
T0514-0244
Triombrin
Triombrin [Russian]
Triombrine
UNII-5UVC90J1LK
Urografic acid, sodium salt
Urografin acid
Urogranoic acid
Urotrast
Urovison
Vascoray
Win 8308-3
WLN: 1VMR BI DI FI CVQ EMV1
ATC-Codes:
Side-Effects:
Side-EffectFrequency
paralysis0
syncope0
swelling0
sweating0
sneezing0
shock0
rhinitis0
pulmonary embolism0
pulmonary edema0
pruritus0
petechiae0
paresthesia0
weakness0
numbness0
neutropenia0
tachycardia0
thrombophlebitis0
tremor0
hypoxia0
speech disturbance0
sinus arrest0
respiratory arrest0
renal colic0
agitation0
sinus bradycardia0
wheezing0
vomiting0
ventricular fibrillation0
urticaria0
uremia0
erythema0
unconsciousness0
nephrosis0
nausea0
myocardial infarction0
cough0
conjunctivitis0
confusion0
coma0
choking0
chest pain0
carcinoma0
bronchospasm0
asthma0
arthralgia0
arrhythmia0
apnea0
angioedema0
anemia0
diarrhea0
dizziness0
somnolence0
transverse myelitis0
leukopenia0
acute tubular necrosis0
hypertension0
hypersensitivity0
hemiparesis0
hematuria0
cardiac arrest0
gangrene0
flushing0
flank pain0
rash0
edema0
dyspnea0
anaphylaxis0

Target

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Uniprot ID:PLMN_HUMAN
Synonyms:
Plasminogen
EC-Numbers:3.4.21.7
Organism:Homo sapiens
Human
PDB IDs:1B2I 1BML 1BUI 1CEA 1CEB 1DDJ 1HPJ 1HPK 1I5K 1KI0 1KRN 1L4D 1L4Z 1PK4 1PKR 1PMK 1QRZ 1RJX 2DOH 2DOI 2PK4 5HPG
Structure:
5HPG

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11981110
An analysis of mechanisms underlying the antifibrinolytic properties of radiographic contrast agents.. P M Farrehi; Y Zhu; W P Fay (2001) Journal of thrombosis and thrombolysis display abstract
BACKGROUND: Radiographic contrast agents inhibit fibrinolysis, although by poorly defined pathways. The purpose of this study was to define specific mechanisms by which contrast agents inhibit clot lysis. METHODS AND RESULTS: Diatrizoate (high osmolar ionic agent), ioxaglate (low osmolar ionic), and ioversol (nonionic) were studied in vitro. Diatrizoate inhibited clot lysis by 81.3+/-0.6% vs. control (p0.3). Inhibition of fibrinolysis was not explained by the high osmolarities of contrast agents, by their iodine content, or by their effects on the amidolytic activities of t-PA, urokinase, or plasmin. However, plasminogen activation by t-PA, urokinase, or streptokinase was significantly inhibited by contrast agents. Diatrizoate, ioxaglate, and ioversol inhibited plasminogen binding to plasma clots by 51+/-4% (p