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Drug-Target Interaction

Drug

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PubChem ID:177
Structure:
Synonyms:
00070_FLUKA
00071_FLUKA
1632-89-9
36611_FLUKA
36611_RIEDEL
402788_SIAL
506788_SUPELCO
63990_FLUKA
75-07-0
AB1002185
AC1L18NF
AC1Q2CBI
ACE
ACETALD
Acetaldehyd
Acetaldehyd [German]
acetaldehyde
Acetaldehyde (natural)
Acetaldehyde polymerized
Acetaldehyde solution
Acetaldehyde [UN1089] [Flammable liquid]
Acetaldehyde [UN1089] [Flammable liquid]
ACETALDEHYDE, ACS
Acetaldehyde-d4
acetaldehydes
Acetaldeyde
Aceteldehyde
acetic aldehyde
Acetic ethanol
ACETYL GROUP
Acetylaldehyde
ACT
ACY
AG-G-99107
AI3-31167
AKOS000120180
aldehyde
Aldehyde acetique
Aldehyde acetique [French]
Aldehyde C(2)
Aldeide acetica
Aldeide acetica [Italian]
Azetaldehyd
BIDD:ER0621
bmse000647
C00084
c0160
CCRIS 1396
CH2CHO
CHEBI:15343
CHEBI:60379
CHEMBL170365
D000079
EINECS 200-836-8
ethaldehyde
ethanal
ethyl aldehyde
Ethylaldehyde
FEMA No. 2003
HSDB 230
I14-6219
LS-1654
LTBB001460
Metaldehyde
NCGC00091753-01
nchem.467-comp3
nchembio.172-comp4
NCI-C56326
NSC 7594
NSC7594
Octowy aldehyd
Octowy aldehyd [Polish]
PS2030_SUPELCO
QMHAIX@
RCRA waste no. U001
RCRA waste number U001
UN1089
W200298_ALDRICH
W200301_ALDRICH
W200328_ALDRICH
W200336_ALDRICH
W200344_ALDRICH
W200352_ALDRICH
W200360_ALDRICH
W200379_ALDRICH
W200387_ALDRICH
WLN: VH1

Target

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Uniprot ID:Q7M053_RAT
Synonyms:
Aldehyde dehydrogenase
EC-Numbers:1.-.-.-
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11022051
The transcriptional and DNA binding activity of peroxisome proliferator-activated receptor alpha is inhibited by ethanol metabolism. A novel mechanism for the development of ethanol-induced fatty liver.. A Galli; J Pinaire; M Fischer; R Dorris; D W Crabb (2001) The Journal of biological chemistry display abstract
Fatty acids are ligands for the peroxisome proliferator-activated receptor alpha (PPAR alpha). Fatty acid levels are increased in liver during the metabolism of ethanol and might be expected to activate PPAR alpha. However, ethanol inhibited PPAR alpha activation of a reporter gene in H4IIEC3 hepatoma cells expressing alcohol-metabolizing enzymes but not in CV-1 cells, which lack these enzymes. Ethanol also reduced the ability of the PPAR alpha ligand WY14,643 to activate reporter constructs in the hepatoma cells or cultured rat hepatocytes. This effect of ethanol was abolished by the alcohol dehydrogenase inhibitor 4-methylpyrazole and augmented by the aldehyde dehydrogenase inhibitor cyanamide, indicating that acetaldehyde was responsible for the action of ethanol. PPAR alpha/retinoid X receptor extracted from hepatoma cells exposed to ethanol or acetaldehyde bound poorly to an oligonucleotide containing peroxisome proliferator response elements. This effect was also blocked by 4-methylpyrazole and augmented by cyanamide. Furthermore, in vitro translated PPAR alpha exposed to acetaldehyde failed to bind DNA. Thus, ethanol metabolism blocks transcriptional activation by PPAR alpha, in part due to impairment of its ability to bind DNA. This effect of ethanol may promote the development of alcoholic fatty liver and other hepatic consequences of alcohol abuse.