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Drug-Target Interaction

Drug

show drug details
PubChem ID:176870
Structure:
Synonyms:
183321-74-6
4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-
4-Quinazolinamine, N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-,
4-[(3-Ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline
4-[(3-ethynylphenyl)amino]-6,7-bis(2-methoxyethoxy)quinazoline;
AB1004620
AC-399
AC1L42EI
AKOS000282911
AQ4
BCB03_000783
C400278
CHEBI:114785
CHEMBL553
CP 358,774
CP 358774
CP-358,774
CP-358774
DB00530
EN002711
Erlotinib
erlotinib HCl
Erlotinib [INN]
Erlotinib(Tarceva)
Erlotinib, OS-774
FT-0083688
HMS2089F05
I01-1241
K00241
Kinome_3317
LS-184395
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine
N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
NCGC00164574-01
NCGC00164574-03
NCGC00164574-05
nchembio866-comp3
NSC 718781
OSI 744
OSI-774
R 1415
SR-05000001460
SR-05000001460-2
STK623143
STOCK6S-52681
Tarceva
UNII-J4T82NDH7E
ZINC01546066
[6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE
[6,7-Bis-(2-methoxy-ethoxy)-quinazolin-4-yl]-(3-ethynyl-phenyl)-amine
ATC-Codes:
Side-Effects:
Side-EffectFrequency
dyspnea0.35
fatigue0.16
pruritus0.05
anorexia0.05
dry skin0.04
stomatitis0.03
conjunctivitis0.02
nausea0.02
paronychia0.0010
hirsutism0.0010
hepatic failure0.0010
keratoconjunctivitis sicca0.0
diarrhea0.0
vomiting0.0
rash0.0
cough0.0
abdominal pain0.0
infection0.0
pneumonia0
rosacea0
myocardial infarction0
nail disorder0
tumor0
ards0
pancreatitis0
pulmonary fibrosis0
peptic ulcer0
pain0
cerebrovascular accident0
insomnia0
acne0
neuropathy0
pulmonary infiltration0
myalgia0
skin fissures0
interstitial lung disease0
interstitial pneumonitis0
hyperpigmentation0
bone pain0
deep vein thrombosis0
weight loss0
erythema0
thrombocytopenia0
syncope0
renal insufficiency0
melena0
edema0
dyspepsia0
dizziness0
dehydration0
dysphagia0
constitutional symptoms0
constipation0
colitis0
cerebral hemorrhage0
cancer0
bronchiolitis0
arthralgia0
arrhythmia0
anxiety0
hemolytic anemia0
epistaxis0
fever0
mediastinal disorders0
lung disorder0
liver disease0
acute renal failure0
hematemesis0
keratoconjunctivitis0
keratitis0
ischemia0
hypokalemia0
hemorrhage0
hematochezia0
headache0
gastrointestinal hemorrhage0
gastritis0
flatulence0
alopecia0

Target

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Uniprot ID:CSK21_HUMAN
Synonyms:
Casein kinase II subunit alpha
CK II
EC-Numbers:2.7.11.1
Organism:Homo sapiens
Human
PDB IDs:1JWH 1NA7 1PJK 2PVR 2ZJW 3BQC 3BW5 3C13 3FWQ 3H30
Structure:
3H30

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
->10000--

References: