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Drug-Target Interaction

Drug

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PubChem ID:1752
Structure:
Synonyms:
104-40-5
25154-52-3
290858_ALDRICH
29832-11-9
3-06-00-02067 (Beilstein Handbook Reference)
4-n-Nonylphenol
4-NONYLPHENOL
4-NP
4-tert-nonylphenol
442873_SUPELCO
46018_FLUKA
46018_RIEDEL
46405_FLUKA
46405_RIEDEL
68081-86-7
AC1L1C5R
AC1Q2VYR
AC1Q7A7Y
AG-D-16604
AR-1G4158
BIDD:ER0006
BIDD:PXR0002
BRN 2047450
BSPBio_002543
C041594
C14550
CCG-39613
CCRIS 1251
CHEBI:34440
CHEMBL153062
DivK1c_006720
EINECS 203-199-4
HSDB 5359
KBio1_001664
KBio2_002530
KBio2_005098
KBio2_007666
KBio3_002043
KBioGR_001263
KBioSS_002539
LS-375
MolPort-001-792-012
NCGC00090918-01
NCGC00090918-02
NCGC00090918-03
NCGC00090918-04
NCGC00090918-05
NCGC00090918-06
NCGC00090918-07
NCGC00090918-08
Nonylphenol
Nonylphenol (mixed)
p -n -Nonylphenol
p-n-Nonylphenol
p-Nonylphenol
P-NONYLPHENOL (ENDOCRINE DISRUPTER)
para-Nonylphenol
Phenol, 4-nonyl-
Phenol, nonyl derivs.
Phenol, nonyl-
Phenol, p-nonyl-
PPT
SBB059316
SPBio_001903
SpecPlus_000624
Spectrum2_001832
SPECTRUM330085
Spectrum3_000872
Spectrum4_000712
Spectrum5_002066
Spectrum_001973
TL8000182

Target

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Uniprot ID:CP1A2_HUMAN
Synonyms:
CYPIA2
Cytochrome P450 1A2
P(3)450
P450 4
P450-P3
EC-Numbers:1.14.14.1
Organism:Homo sapiens
Human
PDB IDs:2HI4
Structure:
2HI4

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

11853173
Inhibition of human hepatic cytochrome P450s and steroidogenic CYP17 by nonylphenol.. Toshiro Niwa; Yumi Maekawa; Megumi Fujimoto; Kae Kishimoto; Yoshiyasu Yabusaki; Fumihide Ishibashi; Masanao Katagiri (2002) Biological & pharmaceutical bulletin display abstract
Effect of nonylphenol on aminopyrine N-demethylase activity, a typical drug-metabolizing enzyme activity, by ten kinds of human hepatic cytochrome P450s (CYP) and on progesterone 17alpha-hydroxylase activity by steroidogenic CYP17 was investigated. When determined at 2 mM substrate concentration, nonylphenol (1 mM) most efficiently inhibited aminopyrine N-demethylation by CYP2C9 and CYP2C19, by 61% and 59%, respectively, followed by CYP2D6, CYP1A2, CYP2C18 and CYP2C8 (46-51%), whereas inhibition of the activities by other CYPs was less than 27%. Additionally, nonylphenol competitively inhibited diclofenac 4'-hydroxylation by CYP2C9 and S-mephenytoin 4'-hydroxylation by CYP2C19 with Ki values of 5.3 and 37 microM, respectively. Furthermore, nonylphenol exhibited a competitive inhibition of progesterone 17alpha-hydroxylase activity by CYP17 with Ki value of 62 microM. These results suggest that nonylphenol inhibits human hepatic CYPs, especially CYP2C9 and CYP2C19, and steroidogenic CYP17 activities.