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Drug-Target Interaction

Drug

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PubChem ID:16741
Structure:
Synonyms:
(2-Isothiocyanato-ethyl)-benzene
(2-isothiocyanatoethyl)benzene
.beta.-Phenethyl isothiocyanate
.beta.-Phenylethyl isothiocyanate
1-(2-isothiocyanatoethyl)benzene
2-isothiocyanatoethylbenzene
2-phenethyl isothiocyanate
2-phenyl ethyl isothiocyanate
2-Phenylethyl isothiocyanate
2-phenylethylisothiocyanate
2257-09-2
253731_ALDRICH
4-12-00-02476 (Beilstein Handbook Reference)
A-Phenethyl isothiocyanate
AB1006056
AC-12769
AC1L28L3
AKOS000119469
b-phenylethyl isothiocyanate
BB_SC-1856
Benzene, (2-isothiocyanatoethyl)-
beta-Phenethyl isothiocyanate
beta-phenethylisothiocyanate
beta-Phenylethyl isothiocyanate
BRN 2084162
C058305
C9H9NS
CCRIS 3146
CHEBI:351346
CHEMBL151649
EINECS 218-855-5
HMS1783C17
I01-3453
I01-8790
Isothiocyanic Acid 2-Phenylethyl Ester
Isothiocyanic acid beta-phenylethyl ester
Isothiocyanic acid, phenethyl ester
IZJDOKYDEWTZSO-UHFFFAOYSA-
LS-7646
MolPort-000-146-876
NCGC00248526-01
NCI60_041942
NSC 87868
NSC87868
P0986
PEITC
PEITC compound
Phenethyl isothiocyanate
Phenethyl mustard oil
Phenylaethylsenfoel
Phenylaethylsenfoel [German]
Phenylethyl isothiocyanate
Phenylethyl mustard oil
STK397325
W401404_ALDRICH
WLN: SCN2R
ZERO/008133
ZINC02022074

Target

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Uniprot ID:MK03_HUMAN
Synonyms:
ERK-1
ERT2
Extracellular signal-regulated kinase 1
Insulin-stimulated MAP2 kinase
MAP kinase 1
MAPK 1
Microtubule-associated protein 2 kinase
Mitogen-activated protein kinase 3
p44-ERK1
p44-MAPK
EC-Numbers:2.7.11.24
Organism:Homo sapiens
Human
PDB IDs:2ZOQ
Structure:
2ZOQ

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

14729592
The chemopreventive agent phenethyl isothiocyanate sensitizes cells to Fas-mediated apoptosis.. Juliet M Pullar; Susan J Thomson; Monica J King; Christopher I Turnbull; Robyn G Midwinter; Mark B Hampton (2004) Carcinogenesis display abstract
The chemopreventive properties of the isothiocyanates have been attributed to their ability to inhibit phase I enzymes that activate procarcinogens, induce phase II protective enzymes and trigger apoptosis in transformed cells. In this study we provide evidence for a new mechanism of chemoprevention, wherein sublethal doses of phenethyl isothiocyanate (PEITC) sensitize cells to Fas-mediated apoptosis. The phenomenon was observed in the Fas-resistant T24 bladder carcinoma cell line and in Jurkat T cells overexpressing the anti-apoptotic protein Bcl-2. Caspase-3-like activity was increased up to 20-fold of that observed with either PEITC or anti-Fas antibody alone. While PEITC activated ERK, JNK and p38, inhibitors of these MAP kinases did not block apoptosis. PEITC transiently depleted cellular glutathione, providing a putative mechanism for sensitizing the cells to apoptosis. However, lowering glutathione with buthionine sulfoximine did not mimic the effect of PEITC. Instead, we propose that PEITC promotes apoptosis by directly modifying intracellular thiol proteins. The ability of PEITC to sensitize cells to receptor-mediated apoptosis provides an additional mechanism to explain its chemopreventive properties.