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Drug-Target Interaction

Drug

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PubChem ID:16684434
Structure:
Synonyms:
((O-CARBOXYPHENYL)THIO) ETHYLMERCURY SODIUM SALT
((o-Carboxyphenyl)thio)ethylmercury sodium salt
11004-81-2
113170-85-7
130995-49-2
2-(Ethylmercuriomercapto)benzoic acid sodium salt
2141-27-7
23065-35-2
25948-50-9
54-64-8
77536-61-9
8030-32-8
8030-33-9
Aeroaid spray
AKOS004910446
C9H9HgO2S.Na
Caswell No. 766
CCG-39725
CCRIS 4839
CHEBI:9546
CHEMBL508338
Collyrium Eye Wash
D00864
EINECS 200-210-4
Elcide 73
Elcide 75
Elicide
EPA Pesticide Chemical Code 078901
Estivin
Ethyl (sodium o-mercaptobenzoato)mercury
Ethyl(2-mercaptobenzoato-S)mercury sodium salt
Ethyl(2-mercaptobenzoato-S)mercury, sodium salt
Ethylmercurithiosalicyclic acid sodium salt
Ethylmercurithiosalicyclic acid, sodium salt
Ethylmercurithiosalicylate sodium
Ethylmercurithiosalicylate sodium salt
Ethylmercurithiosalicylic acid sodium salt
Ethylmercury sodium salt
Ethylmerkurithiosalicilan sodny
Ethylmerkurithiosalicilan sodny [Czech]
HMS1921E07
HMS2092M09
HMS2230I04
HMS501O19
HSDB 7151
LS-1337
Mercurate(1-), ethyl(2-(mercapto-kappaS)benzoato(2-)-kappaO)-, sodium
Mercurate(1-), ethyl(2-mercaptobenzoate(2-)-O,S)-, sodium salt
Mercurate(1-), ethyl(2-mercaptobenzoato(2-)-O,S)-, sodium
Mercurate(1-), ethyl(o-mercaptobenzoato(2-))-, sodium
Mercurothiolate
Mercurothiolatum
Mercury, ((o-carboxyphenyl)thio)ethyl-, sodium salt
Mercury, ethyl (2-mercaptobenzoato-S)-, sodium salt
Mercury, ethyl(2-mercaptobenzoate-S)-, sodium salt
Mercury, ethyl(2-mercaptobenzoato-S)-, sodium salt
Mercury, ethyl(hydrogen o-mercaptobenzoato)-, sodium salt
Mercury, ethyl(hydrogen o-mercaptobenzoato)-, sodium salt (8CI)
Mercury-([o-carboxyphenyl]thio)ethyl sodium salt
Merfamin
Merphol
Merseptyl (VAN)
MERTHIOLATE
Merthiolate (TN)
Merthiolate salt
Merthiolate sodium
Mertorgan
Merzonin
Merzonin sodium
Mixture Name
MLS001336049
MLS001336050
NCGC00094791-01
NCGC00094791-02
NCGC00164425-01
nchembio.368-comp10
Nosemack
NSC 4794
o-(Ethylmercurithio)benzoic acid sodium salt
Prestwick_1021
SET
SMR000875330
Sodium 2-(ethylmercurithio)benzoate
Sodium ethylmercuric thiosalicylate
Sodium ethylmercurithiosalicylate
sodium ethyl[2-(mercapto-kS)benzoato(2-)]mercurate(1-)
sodium ethyl[2-(sulfanyl-kappaS)benzoato(2-)]mercurate(1-)
Sodium merthiolate
Sodium o-(ethylmercurithio)benzoate
sodium [(2-carboxylatophenyl)sulfanyl](ethyl)mercurate(1-)
SPECTRUM1500572
ST51015159
T-3600
T4687_SIGMA
T5125_SIGMA
T8784_SIGMA
Thimerosal
Thimerosal (JAN/USP)
Thimerosal [USAN:JAN]
Thimerosalate
Thimerosalum
Thimerosol
Thimersalate
Thiomersal
Thiomersal (INN)
Thiomersalat
Thiomersalate
Thiomersalum
Thiomersalum [INN-Latin]
Tiomersal
Tiomersal [INN-Spanish]
Tiomersale
Tiomersale [DCIT]
UNII-2225PI3MOV
Vitaseptol Loesung
[(o-carboxyphenyl)thio]ethylmercury sodium salt
ATC-Codes:

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

12773768
Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts.. David S Baskin; Hop Ngo; Vladimir V Didenko (2003) Toxicological sciences : an official journal of the Society of Toxicology display abstract
Thimerosal is an organic mercurial compound used as a preservative in biomedical preparations. Little is known about the reactions of human neuronal and skin cells to its micro- and nanomolar concentrations, which can occur after using thimerosal-containing products. A useful combination of fluorescent techniques for the assessment of thimerosal toxicity is introduced. Short-term thimerosal toxicity was investigated in cultured human cerebral cortical neurons and in normal human fibroblasts. Cells were incubated with 125-nM to 250-microM concentrations of thimerosal for 45 min to 24 h. A 4', 6-diamidino-2-phenylindole dihydrochloride (DAPI) dye exclusion test was used to identify nonviable cells and terminal transferase-based nick-end labeling (TUNEL) to label DNA damage. Detection of active caspase-3 was performed in live cell cultures using a cell-permeable fluorescent caspase inhibitor. The morphology of fluorescently labeled nuclei was analyzed. After 6 h of incubation, the thimerosal toxicity was observed at 2 microM based on the manual detection of the fluorescent attached cells and at a 1-microM level with the more sensitive GENios Plus Multi-Detection Microplate Reader with Enhanced Fluorescence. The lower limit did not change after 24 h of incubation. Cortical neurons demonstrated higher sensitivity to thimerosal compared to fibroblasts. The first sign of toxicity was an increase in membrane permeability to DAPI after 2 h of incubation with 250 microM thimerosal. A 6-h incubation resulted in failure to exclude DAPI, generation of DNA breaks, caspase-3 activation, and development of morphological signs of apoptosis. We demonstrate that thimerosal in micromolar concentrations rapidly induce membrane and DNA damage and initiate caspase-3-dependent apoptosis in human neurons and fibroblasts. We conclude that a proposed combination of fluorescent techniques can be useful in analyzing the toxicity of thimerosal.