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Drug-Target Interaction

Drug

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PubChem ID:1663
Structure:
Synonyms:
3-(Hydrazinomethyl)phenol
3-(HydrazinYl-Methyl)Phenol Dihydrochloride
3-(hydrazinylmethyl)phenol
3-Hydroxybenzylhydrazine
3-Hydroxybenzylhydrazine dihydrochloride
637-33-2
AB1007393
AC1L1BYI
AC1Q555T
AC1Q79X9
AR-1E7754
BRD-K66416915-300-01-2
BRN 1841459
BSPBio_002252
C7H10N2O
CCG-204686
CHEBI:367928
CHEMBL352205
DivK1c_006881
HYDRAZINE, 1-(3-HYDROXYBENZYL)-
KBio1_001825
KBio2_000793
KBio2_003361
KBio2_005929
KBio3_001472
KBioGR_001618
KBioSS_000793
Lopac-H-9382
Lopac0_000597
LS-76820
m-Hydroxybenzyl hydrazine
m-hydroxybenzylhydrazine
m-Hydroxybenzylhydrazine;
NCGC00015524-01
NCGC00015524-02
NCGC00162200-01
nchembio.78-comp3
Nsd 1015
NSD-1015
SpecPlus_000785
Spectrum3_000726
Spectrum4_001209
Spectrum5_001883
Spectrum_000313
ZINC19168421

Target

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Uniprot ID:GABT_PIG
Synonyms:
(S)-3-amino-2-methylpropionate transaminase
4-aminobutyrate aminotransferase, mitochondrial
GABA aminotransferase
GABA transaminase
GABA-AT
GABA-T
Gamma-amino-N-butyrate transaminase
L-AIBAT
EC-Numbers:2.6.1.19
2.6.1.22
Organism:Pig
Sus scrofa
PDB IDs:1OHV 1OHW 1OHY
Structure:
1OHY

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----
-460--
300---

References:

7648206
Time-dependent inhibition of gamma-aminobutyric acid aminotransferase, by 3-hydroxybenzylhydrazine.. E S Lightcap; M H Hopkins; G T Olson; R B Silverman (1995) Bioorganic & medicinal chemistry display abstract
gamma-Aminobutyric acid (GABA) aminotransferase is a pyridoxal 5'-phosphate (PLP)-dependent enzyme that catalyzes the conversion of GABA into succinic semialdehyde. Hydrazine analogues have long been known to act as inactivators of PLP-dependent enzymes, including GABA aminotransferase, however, no studies of the molecular mechanism of inactivation of PLP-dependent enzymes by hydrazines have been reported. 3-Hydroxybenzylhydrazine is shown to be a potent in vitro time-dependent inhibitor of pig brain GABA aminotransferase. UV-visible and 1H NMR studies, both with GABA aminotransferase and with PLP as a chemical model for the enzyme-catalyzed reaction, indicate that 3-hydroxybenzylhydrazine reacts both enzymatically and nonenzymatically to form the 3-hydroxybenzylhydrazone of PLP without tautomerization.