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Drug-Target Interaction

Drug

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PubChem ID:1645
Structure:
Synonyms:
253014_ALDRICH
253014_SIGMA
3-AB
3-AB cpd
3-ABA
3-amino benzamide
3-Amino-benzamide
3-Aminobenzamide
3-Aminobenzimide
3544-24-9
3AB
4-14-00-01094 (Beilstein Handbook Reference)
A 0788
A0630
A0788_SIGMA
AC-10266
AC1L1BX0
AC1Q4ZAY
AC1Q4ZAZ
AG-F-22659
AIDS-059768
AIDS059768
AKOS000118163
Ambap3139
ARONIS015032
BB_SC-7456
BCBcMAP01_000186
Benzamide, 3-amino-
Benzamide, 3-amino- (9CI)
Benzamide, m-amino-
Bio1_000466
Bio1_000955
Bio1_001444
Bio2_000152
Bio2_000632
Biochem Biophys Res Commun 225: 826
BRN 2802373
BSPBio_001432
BSPBio_002603
C025160
C7H8N2O
CCG-39623
CCRIS 3925
CHEMBL81977
cMAP_000029
DivK1c_000717
EINECS 222-586-9
EU-0100043
HMS1361H14
HMS1791H14
HMS1989H14
HMS3260I07
HMS502D19
HSCI1_000265
HSDB 7581
I01-3900
IDI1_000717
IDI1_033902
INO-1001-Supplied by Selleck Chemicals
INO1001, INO-1001
KBio1_000717
KBio2_000152
KBio2_001972
KBio2_002355
KBio2_002720
KBio2_004540
KBio2_004923
KBio2_005288
KBio2_007108
KBio2_007491
KBio3_000303
KBio3_000304
KBio3_001823
KBio3_002834
KBioGR_000152
KBioGR_001512
KBioGR_002355
KBioSS_000152
KBioSS_001972
KBioSS_002358
Lopac-A-0788
Lopac0_000043
LS-25343
m-amino benzamide
m-Aminobenzamide
meta-aminobenzamide
MLS002153497
MolPort-000-150-925
NCGC00015034-01
NCGC00015034-02
NCGC00015034-03
NCGC00015034-04
NCGC00015034-05
NCGC00015034-06
NCGC00015034-07
NCGC00015034-08
NCGC00024792-01
NCGC00024792-02
NCGC00024792-03
NCGC00024792-04
NCGC00024792-05
NCGC00024792-06
NINDS_000717
NSC 36962
NSC36962
Oprea1_589004
PARP Inhibitor I, 3-ABA
S1132_Selleck
SMP2_000089
SMR000375902
SPBio_001514
Spectrum2_001577
Spectrum3_000972
Spectrum4_001096
Spectrum5_001459
Spectrum_001492
STK730785
Tocris-0788
UPCMLD-DP128
UPCMLD-DP128:001
ZINC00157165

Target

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Uniprot ID:Q6LBH1_HUMAN
Synonyms:
Acid phosphatase
Prostatic acid phosphotase
EC-Numbers:3.1.3.2
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

3085478
Influence of the poly (ADP-ribose) polymerase inhibitor 3-aminobenzamide on macrophage and granulocyte differentiation of HL-60 cells.. N Damji; K E Khoo; L Booker; G P Browman (1986) American journal of hematology display abstract
We investigated the influence of the poly(ADP-ribose) polymerase inhibitor 3-aminobenzamide (ABA) on induction of phenotypic markers of granulocyte differentiation by retinoic acid and markers of macrophage differentiation by TPA in HL-60 cells. The differentiation of HL-60 cells towards the granulocyte lineage was assessed by hexose monophosphate shunt activity, proportion of cells capable of reducing NBT dye, and the appearance of recognizable neutrophils and bands. The effect of ABA and retinoic acid on NBT dye reduction and appearance of mature neutrophils and bands was synergistic, whereas the effects of these agents on hexose monophosphate shunt activity were additive. The differentiation inducing capacity of ABA in the presence of retinoic acid was dose-related. The influence of ABA on TPA-induced markers of macrophage differentiation was assessed by determining the proportion of adherent cells produced after treatment and by measuring acid phosphatase activity in the adherent cell fraction. In the presence of ABA, the number of cells adhering to plastic declined after day 2 of exposure to TPA, and acid phosphatase activity in adherent cells was inhibited fourfold (p = 0.01). The influence of ABA on the phenotypic markers of granulocyte and macrophage differentiation was detectable at concentrations that were not cytotoxic. The influence of ABA on HL-60 differentiation is similar to that previously reported for human bone marrow CFU-GM. Our data suggest that poly(ADP-ribose) polymerase plays a role in differentiation of HL-60 cells and that HL-60 might provide a useful model for evaluating control mechanisms involved in the differentiation of CFU-GM.