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Drug-Target Interaction

Drug

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PubChem ID:1645
Structure:
Synonyms:
253014_ALDRICH
253014_SIGMA
3-AB
3-AB cpd
3-ABA
3-amino benzamide
3-Amino-benzamide
3-Aminobenzamide
3-Aminobenzimide
3544-24-9
3AB
4-14-00-01094 (Beilstein Handbook Reference)
A 0788
A0630
A0788_SIGMA
AC-10266
AC1L1BX0
AC1Q4ZAY
AC1Q4ZAZ
AG-F-22659
AIDS-059768
AIDS059768
AKOS000118163
Ambap3139
ARONIS015032
BB_SC-7456
BCBcMAP01_000186
Benzamide, 3-amino-
Benzamide, 3-amino- (9CI)
Benzamide, m-amino-
Bio1_000466
Bio1_000955
Bio1_001444
Bio2_000152
Bio2_000632
Biochem Biophys Res Commun 225: 826
BRN 2802373
BSPBio_001432
BSPBio_002603
C025160
C7H8N2O
CCG-39623
CCRIS 3925
CHEMBL81977
cMAP_000029
DivK1c_000717
EINECS 222-586-9
EU-0100043
HMS1361H14
HMS1791H14
HMS1989H14
HMS3260I07
HMS502D19
HSCI1_000265
HSDB 7581
I01-3900
IDI1_000717
IDI1_033902
INO-1001-Supplied by Selleck Chemicals
INO1001, INO-1001
KBio1_000717
KBio2_000152
KBio2_001972
KBio2_002355
KBio2_002720
KBio2_004540
KBio2_004923
KBio2_005288
KBio2_007108
KBio2_007491
KBio3_000303
KBio3_000304
KBio3_001823
KBio3_002834
KBioGR_000152
KBioGR_001512
KBioGR_002355
KBioSS_000152
KBioSS_001972
KBioSS_002358
Lopac-A-0788
Lopac0_000043
LS-25343
m-amino benzamide
m-Aminobenzamide
meta-aminobenzamide
MLS002153497
MolPort-000-150-925
NCGC00015034-01
NCGC00015034-02
NCGC00015034-03
NCGC00015034-04
NCGC00015034-05
NCGC00015034-06
NCGC00015034-07
NCGC00015034-08
NCGC00024792-01
NCGC00024792-02
NCGC00024792-03
NCGC00024792-04
NCGC00024792-05
NCGC00024792-06
NINDS_000717
NSC 36962
NSC36962
Oprea1_589004
PARP Inhibitor I, 3-ABA
S1132_Selleck
SMP2_000089
SMR000375902
SPBio_001514
Spectrum2_001577
Spectrum3_000972
Spectrum4_001096
Spectrum5_001459
Spectrum_001492
STK730785
Tocris-0788
UPCMLD-DP128
UPCMLD-DP128:001
ZINC00157165

Target

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Uniprot ID:DCHS_RAT
Synonyms:
HDC
Histidine decarboxylase
EC-Numbers:4.1.1.22
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

2521450
Induction of histidine decarboxylase in rat basophilic leukemia cells by interferon and prevention of its effect in coincubation with ADP-ribosyltransferase inhibitors.. T Kito; M Kubota; T Takimoto; Y Akiyama; T Heike; H Mikawa (1989) Biochemical and biophysical research communications display abstract
Treatment of rat basophilic leukemia cell line (2H3) with interferon-alpha significantly increased intracellular histamine levels. On the other hand, the histidine content was decreased reciprocally by interferon in a dose-dependent manner. Concomitantly, the activity of histidine decarboxylase, the enzyme responsible for histamine synthesis, was augmented. The increase in histidine decarboxylase activity was partially abolished in co-incubation with inhibitors of ADP-ribosyltransferase, such as 3-aminobenzamide or nicotinamide. These results suggest the pivotal role of activation of histidine decarboxylase, presumably through ADP-ribosylation of the enzyme, in interferon-induced histamine synthesis.