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Drug-Target Interaction

Drug

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PubChem ID:1548887
Structure:
Synonyms:
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-, (Z)-
32004-68-5
38194-50-2
5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
9000-14-0
AB00513800
Aclin
Alphapharm Brand of Sulindac
Apo Sulin
Apo-Sulin
Apotex Brand of Sulindac
Arthrobid
Arthrocine
BPBio1_000315
BRN 2951842
BSPBio_000285
BSPBio_002890
C01531
C20H17FO3S
Cahill May Roberts Brand of Sulindac
CAS-38194-50-2
CCRIS 3305
CHEBI:9352
Chemia Brand of Sulindac
Chibret
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
Clinoril
Clinoril (TN)
cMAP_000021
Copal
Copal resin
Copal rosin varnish
Copals
D00120
D013467
EINECS 232-527-9
EINECS 250-893-8
EINECS 253-819-2
EU-0101070
Gum copal
IDI1_000601
Kenalin
Kendrick Brand of Sulindac
Klinoril
Lopac-S-8139
Lopac0_001070
LS-81610
Merck Brand of Sulindac
Merck Sharp & Dohme Brand of Sulindac
MK 231
MK-231
MK231
MLS001056554
Mobilin
NCGC00015970-01
NCGC00015970-02
NCGC00025268-01
NCGC00025268-02
NCGC00025268-03
NCGC00094349-01
NCGC00094349-02
Novo Sundac
Novo-Sundac
Novopharm Brand of Sulindac
Nu Pharm Brand of Sulindac
Nu Sulindac
Nu-Pharm Brand of Sulindac
Nu-Sulindac
Prestwick3_000073
Resin copal
SMR000326718
SPECTRUM1500556
Spectrum5_001024
Sulindac
Sulindac (JAN/USP/INN)
Sulindac sulfoxide
Sulindac [USAN:BAN:INN:JAN]
Sulindaco
Sulindaco [INN-Spanish]
Sulindacum
Sulindacum [INN-Latin]
Sulindal
Tocris-1707
{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
ATC-Codes:

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
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References:

12017300
Sulindac induces apoptosis, inhibits proliferation and activates caspase-3 in Hep G2 cells.. Jian-Jun Liu; Ji-Yao Wang; Erik Hertervig; Ake Nilsson; Rui-Dong Duan (2002) Anticancer research display abstract
BACKGROUND: It has recently been reported that sulindac has an apoptotic effect on KYN-2 cells, an undifferentiated hepatoma cell line. The present work investigates whether sulindac also has an apoptotic effect on well-differentiated hepatoma cells and what its potential mechanism might be. MATERIALS AND METHODS: Hep G2 cells were treated with sulindac at different concentrations. Apoptosis rate, cell proliferation and 3H-thymidine incorporation were measured. The activities of caspase-3, acid and neutral sphingomyelinase and the changes of sphingomyelin content were also assayed. RESULTS: Sulindac dose-dependently induced apoptosis in Hep G2 cells; both sulindac sulfone and sulfide had similar effects. The apoptosis was accompanied by an increase of caspase-3 activity and a decrease of cell proliferation and 3H-thymidine incorporation. No significant change could be observed for the activity of sphingomyelinase and sphingomyelin content. CONCLUSION: Sulindac induces apoptosis and inhibits proliferation in Hep G2 cells. The effect may be mediated by a pathway related to caspase-3 activation but independent of sphingomyelin metabolism