Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:13804
Structure:
Synonyms:
1477-47-0
5'-O-[hydroxy({[2-(trimethylammonio)ethoxy]phosphinato}oxy)phosphoryl]cytidine
987-78-0
Ambap5334
BRN 4170138
C00307
C12H20N3O11P2
CDC
CDP Choline
CDP-cholin [German]
CDP-choline
CDP-colina
CDP-colina [Spanish]
Cereb
CHEBI:16436
Choline 5'-cytidine diphosphate
Choline cytidine 5'-pyrophosphate ester
Choline cytidine diphosphate
Choline, ester with cytidine 5'-pyrophosphate
Choline, hydroxide, 5'-ester with cytidine 5'-(trihydrogen pyrophosphate),
Choline, hydroxide, 5'-ester with cytidine 5'-(trihydrogen pyrophosphate), inner salt
Cidifos
Citicholine
Citicolina
Citicolina [INN-Spanish]
Citicoline
Citicoline (JAN/INN)
Citicoline [INN:JAN]
Citicolinum
Citicolinum [INN-Latin]
citidin difosfato de colina
Citidin difosfato de colina [Spanish]
Citidoline
Colite
CPD000468735
Cyscholin
Cyticholine
Cytidindiphosphocholin
Cytidindiphosphocholin [German]
Cytidine 5'-(choline diphosphate)
Cytidine 5'-(cholinyl pyrophosphate)
Cytidine 5'-(trihydrogen diphosphate), mono(2-(trimethylammonio)ethyl) ester, hydroxide, inner salt
Cytidine 5'-(trihydrogen diphosphate), P'-(2-(trimethylammonio)ethyl) ester, inner salt
Cytidine 5'-diphosphate choline
Cytidine 5'-diphosphocholine
Cytidine 5'-diphosphoric choline
Cytidine choline diphosphate
Cytidine diphosphate cholin ester
Cytidine diphosphate choline
Cytidine diphosphate choline ester
Cytidine diphosphocholine
Cytidine diphosphorylcholine
Cytidine, 5'-pyrophosphate, ester with choline
Cytidinediphosphoric choline
Cytidoline
D00057
Difosfocin
EINECS 213-580-7
Emicholin
Ensign
Haocolin
LS-53241
Meibis
Nicholin
Nicholin (TN)
Nicolin
Niticolin
NSC 122002
Recofnan
Recognan
SAM001247058
Somazina
Suncholin
[2-CYTIDYLATE-O'-PHOSPHONYLOXYL]-ETHYL-TRIMETHYL-AMMONIUM
ATC-Codes:

Target

show target details
Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

12015211
CDP-choline reduces pro-caspase and cleaved caspase-3 expression, nuclear DNA fragmentation, and specific PARP-cleaved products of caspase activation following middle cerebral artery occlusion in the rat.. J Krupinski; I Ferrer; M Barrachina; J J Secades; J Mercadal; R Lozano (2002) Neuropharmacology display abstract
Citicoline has been demonstrated to be beneficial in several models of cerebral ischaemia. We tested the hypothesis that citicoline may provide apoptotic pathways following focal cerebral ischaemia. Focal cerebral ischaemia was produced by distal, permanent middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats. The animals were randomised into four groups: (B+A) Citicoline 500 mg/kg IP 24 and 1 h before MCAO, and 23 h after MCAO; (A) citicoline 500 mg/kg IP, within 30 min after MCAO, and 23 h after MCAO; (C) vehicle IP; and (D) sham-operated. The animals were sacrificed at 12 h (n=8 per group) and 24 h (n=8 per group) after MCAO. Immunohistochemistry was performed on free-floating tissue sections with goat polyclonal antibodies to procaspase-1, -2, -3, -6 and -8, and in paraffin-embedded sections processed for cleaved caspase-3 (17 kDa) immunohistochemistry. Finally, some sections were stained with the method of in situ end-labelling of nuclear DNA fragmentation. For gel electrophoresis and Western blotting, antibodies to poly (ADP-ribose) polymerase (PARP) products of 89 kDa were used to reveal specific cleavage substrates of caspases. MCAO induced the expression of all procaspases and the expression of PARP products of 89 kDa, as well as cells with nuclear DNA fragmentation, at 12 and 24 h, in the infarcted core and penumbra. Citicoline reduced the expression of all procaspases at 12 and 24 h after MCAO, as well as the expression of cleaved caspase-3 in cells in the penumbra area. This was accompanied by a reduction in the number of cells bearing nuclear DNA fragments. The expression of caspase-cleaved products of PARP (PARP 89 kDa) was reduced in citicoline-treated ischaemic rats. These results show that citicoline inhibits the expression of proteins involved in apoptosis following MCAO.