Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug-Target Interaction

Drug

show drug details
PubChem ID:1140
Structure:
Synonyms:
108-88-3
155004_SIAL
179418_SIAL
179965_ALDRICH
179965_SIAL
2037-26-5
244511_ALDRICH
244511_SIAL
300204X
3101-08-4
314358_SIGMA
322245_SIGMA
32249_RIEDEL
32249_SIAL
34413_FLUKA
34413_RIEDEL
34494_FLUKA
34494_RIEDEL
34866_SIAL
48572_SUPELCO
50643-04-4
676756_SIAL
89677_FLUKA
89677_SIAL
89680_FLUKA
89681_FLUKA
AC1L1ATE
AC1L4W1C
AG-D-25512
AI3-02261
antisal 1a
Benzene, methyl
Benzene, methyl-
BIDD:ER0288
c0114
C01455
Caswell No. 859
CCRIS 2366
CHEBI:17578
CHEMBL9113
CP 25
D014050
DB01900
EINECS 203-625-9
EPA Pesticide Chemical Code 080601
HSDB 131
I01-4407
LS-26
LTBB002867
MBN
methacide
Methane, phenyl-
methyl-Benzene
methylbenzene
methylbenzol
Methylene, phenyl-
monomethyl benzene
NCGC00090939-01
NCGC00090939-02
NCGC00090939-03
NCI-C07272
NSC 406333
NSC406333
OCTADEUTEROTOLUENE
Otoline
phenyl methane
Phenylmethane
Phenylmethylene
RCRA waste no. U220
RCRA waste number U220
S0638
ST5214497
T0260
Tol
tolu-sol
Tolueen
Tolueen [Dutch]
Toluen
Toluen [Czech]
TOLUENE
TOLUENE (SEE ALSO TOLUENE (TECHNICAL), NTP 11617-L)
Toluene (Technical)
TOLUENE (TECHNICAL) (SEE ALSOTOLUENE (NITRATION GRADE) NTP10009-V)
Toluene [UN1294] [Flammable liquid]
Toluene [UN1294] [Flammable liquid]
TOLUENE- D8
Toluene-(ring-UL-14C)
Tolueno
Tolueno [Spanish]
toluol
Toluolo
Toluolo [Italian]
UN 1294
UN1294
UNII-3FPU23BG52
UNL
WLN: 1R

Target

show target details
Uniprot ID:CP3A1_RAT
Synonyms:
CYPIIIA1
Cytochrome P450 3A1
P450-PCN1
EC-Numbers:1.14.14.1
Organism:Rat
Rattus norvegicus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

8347164
Monoclonal antibody-directed assessment of toluene induction of rat hepatic cytochrome P450 isozymes.. R S Wang; T Nakajima; S S Park; H V Gelboin; N Murayama (1993) Biochemical pharmacology display abstract
Cytochrome P450 isozymes induced in rat liver by a range of concentrations of toluene were studied with monoclonal antibodies (MAbs) to specific P450 isozymes and by enzyme assays. Nitrosodimethylamine demethylase activity was significantly increased in microsomes from rats exposed to more than 1000 ppm of toluene, an increase that was dose-dependent. Anti-CYP2E1 significantly inhibited the metabolism of toluene to benzyl alcohol (BA) by about 50%, in microsomes from 1000 to 4000 ppm toluene-exposed rats, at low substrate concentration (0.2 mM). With anti-CYP2B1/2, the rate of BA formation was decreased by 15-17% in microsomes from rats of 2000 and 4000 ppm toluene exposures at high substrate concentration (5.0 mM). On the other hand, anti-CYP2C11/6 inhibited the rate of formation of BA in all of the microsomes, but the extent of inhibition was progressively decreased from 55% in control to 33% in 4000 ppm exposure. Immunoblot analysis with anti-CYP2E1 and anti-CYP2B1/2 revealed stronger immunoreactive bands in microsomes from rats exposed to more than 1000 and 2000 ppm of toluene, respectively. Stronger bands were also observed in microsomes from rats of 2000-4000 ppm toluene exposures with anti-CYP3A1/2, but no immunoreactivity appeared with anti-CYP1A1/2. These results suggest that toluene induces CYP2E1, CYP2B1/2 and CYP3A1/2, but reduces CYP2C11/6, and has no effect on CYP1A1/2.