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Drug-Target Interaction

Drug

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PubChem ID:11
Structure:
Synonyms:
.alpha.,.beta.-Dichloroethane
02562_FLUKA
03521_FLUKA
03527_FLUKA
03527_SIAL
03530_FLUKA
1,2-Bichloroethane
1,2-DCE
1,2-Dichloorethaan
1,2-Dichloorethaan [Dutch]
1,2-Dichlor-aethan
1,2-Dichlor-aethan [German]
1,2-Dichloraethan
1,2-Dichlorethane
1,2-dichloroethane
1,2-DICHLOROETHANE, ACS
1,2-Dicloroetano
1,2-Dicloroetano [Italian]
1,2-Ethylene dichloride
1,2-Ethylidene dichloride
107-06-2
12-DICHLOROETHANE
154784_ALDRICH
154784_SIAL
2-Dichloroethane
284505_ALDRICH
284505_SIAL
300059X
319929_SIAL
48509_SUPELCO
52399-93-6
AC1L189Y
AC1Q3UNO
AC1Q3UNP
Aethylenchlorid
Aethylenchlorid [German]
Aethylendichlorid
AI3-01656
AKOS000120021
alpha, beta-dichloroethane
alpha,beta-Dichloroethane
AR-1I4181
Bichlorure D'ethylene
Bichlorure d'ethylene [French]
bmse000568
Borer sol
Brocide
c0001
C024565
C06752
Caswell No. 440
CCRIS 225
CHEBI:27789
CHEMBL16370
Chlorure D'ethylene
Chlorure d'ethylene [French]
Cloruro di ethene
Cloruro di ethene [Italian]
D0310
D0364
D61563_ALDRICH
D61563_SIAL
DB03733
DCE
destruxol borer- sol
Destruxol borer-sol
Di-chlor-mulsion
Dichlor-Mulsion
Dichloremulsion
Dichloro-1,2-ethane
Dichloro-1,2-ethane [French]
dichloroethane
Dichloroethane, 1,2-
Dichloroethylene
Dichlorure d'ethylene
Dichlorure d'ethylene [ISO-French]
Dutch liquid
Dutch oil
EDC
EDC (halocarbon)
EINECS 203-458-1
ENT 1,656
EPA Pesticide Chemical Code 042003
Ethane dichloride
Ethane, 1,2-dichloro-
Ethyleendichloride
Ethyleendichloride [Dutch]
Ethylene chloride
Ethylene dichloride
Ethylene dichloride [BSI:ISO]
Ethylene dichloride [UN1184] [Flammable liquid]
Ethylene dichloride [UN1184] [Flammable liquid]
ethylene dichloride, 14C-labeled
ethylene dichloride, 14C2-labeled
ethylene dichloride, 36Cl-labeled
ethylene dichloride, 38Cl-labeled
ethylene dichloride, ion (1+)
Freon 150
Glycol dichloride
HCC 150
HSDB 65
I14-7134
LS-425
MolPort-000-871-958
NCGC00091763-01
NCGC00091763-02
NCGC00091763-03
nchembio.205-comp5
NCI-C00511
RCRA waste no. U077
RCRA waste number U077
RY Dichloro-1,2-ethane
SBB040805
ST5214371
sym-Dichloroethane
UN1184
ZINC08220695

Target

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Uniprot ID:Q9UE37_HUMAN
Synonyms:
Glutathione transferase
EC-Numbers:2.5.1.18
Organism:Homo sapiens
Human
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

3296321
Human erythrocyte glutathione S-transferase: a possible marker of chemical exposure.. G A Ansari; S V Singh; J C Gan; Y C Awasthi (1987) Toxicology letters display abstract
We have explored the possibility of using glutathione S-transferase (GST) as a biological marker of chemical exposure. All the model compounds tested in the present study (acrolein, propylene oxide, styrene oxide, ethylene dibromide and ethylene dichloride) showed a dose-dependent inactivation of erythrocyte GST in situ as well as the inhibition of purified erythrocyte GST.