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Drug-Target Interaction

Drug

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PubChem ID:10868
Structure:
Synonyms:
1,3-Dicyclohexylcarbodiimide
36650_FLUKA
36651_ALDRICH
36651_FLUKA
379115_ALDRICH
4-12-00-00072 (Beilstein Handbook Reference)
538-75-0
AB1002886
AC1L1W4E
AC1Q4T8X
acetic acid, cyano-, ethyl ester
AG-F-85691
AI3-08191
AKOS000120067
Ambap4714
BB_SC-6630
Bis(cyclohexyl)carbodiimide
BRN 0610662
Carbodicyclohexylimide
Carbodiimide, dicyclohexyl-
CARBODIIMIDE,DICYCLOHEXYL
CCRIS 9266
CHEBI:53090
CHEMBL162598
CPD-10322
Cyclohexaamine, N,N'-methanetetraylbis-
Cyclohexaamine, N,N'-methanetetraylbis- (9CI)
Cyclohexanamine, N,N'-methanetetraylbis-
D004024
D0436
D0437
D80002_ALDRICH
DCC
DCC solution
DCCD
DCCI
Dicyclohexyl-carboxydilmide
Dicyclohexylcarbodiimide
dicyclohexylmethanediimine
Dicylcohexylcarbodiimide
EINECS 208-704-1
I05-0100
LS-200
MolPort-000-154-198
n,n' dicyclohexyl carbodiimide
n,n'-dicyclohexyl carbodiimide
N,N'-DICYCLOHEXYL-CARBODIIMIDE
n,n'-dicyclohexylcarbodiimid
N,N'-Dicyclohexylcarbodiimide
N,N'-Dicyclohexylcarbodiimide solution
N,N'-dicyclohexylmethanediimine
n,n'-dicylohexylcarbodiimide
n,n'-methanediylidenedicyclohexanamine
N,N'-Methanetetraylbiscyclohexaamine
n,n-dichyclohexylcarbodiimide
n,n-dicychohexylcarbodiimide
n,n-dicyclohexylcarbodiimide
NCGC00091497-01
NCGC00091497-02
NCGC00091497-03
NCGC00091497-04
nchembio884-comp2
NSC 30022
NSC30022
NSC53373
NSC57182
STL089892
TL8003534
ZINC08585900

Target

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Uniprot ID:AT1A3_MOUSE
Synonyms:
Na(+)/K(+) ATPase alpha(III) subunit
Na(+)/K(+) ATPase alpha-3 subunit
Sodium pump subunit alpha-3
Sodium/potassium-transporting ATPase subunit alpha-3
EC-Numbers:3.6.3.9
Organism:Mouse
Mus musculus
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

195894
Induction of cell division in BALB/c-3T3 cells by phorbol myristate acetate or bovine serum: effects of inhibitors of cyclic AMP phosphodiesterase and Na+-K+-ATPase.. A Sivak (1977) In vitro display abstract
Cell division is induced in stationary cultures of BALB/c-3T3 mouse embryo cells without renewal of medium by addition of the tumor promoter, phorbol myristate acetate (PMA), or bovine serum. The addition of dbcAMP (10(-3) M) or other inhibitors of cAMP phosphodiesterase, papaverine (6.7 X 10(-6) M), Persantin (5 X 10(-5) M) or RO-20-1724 (10(-4) M), prevents cell replication induced by PMA or serum. In contrast, ouabain (10(-4) M) and N,N'-dicyclohexylcarbodiimide (10(-5) M), inhibitors of Na+-K+-ATPase activity, block the PMA-stimulated effect but do not inhibit serum-stimulated cell division. Several stages in the cell cycle are sensitive to dbcAMP addition. One is early in the G1 phase at the time of reinitiation of the cell cycle from a stationary (Go) phase, a second is associated with the G1-S transition, and a third with passage of cells from a post-S phase to mitosis. Based on observations of early morphological changes, responses of plasma membrane enzymes and effects of enzyme inhibitors, the stimulation of cell division in BALB/c-3T3 cells by PMA or serum appears to involve several membrane functions which may act in a cooperative manner.