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Drug-Target Interaction

Drug

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PubChem ID:1049
Structure:
Synonyms:
02486_FLUKA
0PY
110-86-1
152758-95-7
15598-34-2
15598-34-2 (perchlorate)
163392-20-9
184527_ALDRICH
184527_SIAL
18820-82-1
18820-82-1 (hydrobromide)
270407_ALDRICH
270407_SIAL
270970_ALDRICH
270970_SIAL
300181X
32001-55-1
32001-55-1 (hydrofluoride)
33638_FLUKA
33638_RIEDEL
34945_RIEDEL
34945_SIAL
360570_SIAL
45410-39-7
494410_ALDRICH
494410_SIAL
543-54-4
543-54-4 (monosulfate)
62301-32-0
628-13-7
628-13-7 (hydrochloride)
676772_SIAL
6999-00-4
7291-22-7
733733-47-6
82005-06-9
82702_FLUKA
82702_SIAL
82704_FLUKA
82704_SIAL
85404-19-9
85404-20-2
857961-06-9
AC-907/34116015
AC1L1AM2
AC1Q2AR9
AC1Q2ARA
AG-D-28611
AI3-01240
AKOS000120998
Azabenzene
Azine
bmse000432
C00747
Caswell No. 717
CCRIS 2926
CHEBI:16227
CHEMBL266158
CP 32
EINECS 203-809-9
EPA Pesticide Chemical Code 069202
FEMA No. 2966
FEMA Number 2966
HSDB 118
I02-1797
LS-13
LTBB002420
NCGC00091476-01
NCGC00091476-02
nchem.892-comp2
NCI-C55301
NCI60_006101
NCIOpen2_002809
NCIOpen2_007786
NCIOpen2_007866
NCIOpen2_007986
NCIOpen2_007999
NSC 406123
NSC141574
NSC406123
P57506_SIAL
Piridina
Piridina [Italian]
Pirydyna
Pirydyna [Polish]
PLA
py
Pyr
Pyridin
Pyridin [German]
Pyridine
pyridine fraction
Pyridine hydrochloride
Pyridine [UN1282] [Flammable liquid]
Pyridine [UN1282] [Flammable liquid]
PYRIDINE, ACS
PYRIDINE- D5
PYRIDINE-RING
Q0034
RCRA waste no. U196
RCRA waste number U196
ST5214494
TRANSGENIC LECM (PYRIDINE)
UN1282
W296600_ALDRICH
WLN: T6NJ
ZINC00895354

Target

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Uniprot ID:PPOB_SOLTU
Synonyms:
Catechol oxidase B, chloroplastic
Polyphenol oxidase
PPO
EC-Numbers:1.10.3.1
Organism:Potato
Solanum tuberosum
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

1435072
Pyridine and other coal tar constituents as inhibitors of potato polyphenol oxidase: a non-animal model for neurochemical studies.. H M Henderson; N A Eskin; C Pinsky; R Bose; A M Ashique (1992) Life sciences display abstract
Potato polyphenol oxidase activity was strongly and noncompetitively inhibited by the "Perov mixture" of coal tar components and by pyridine alone, while phenol competitively inhibited the enzyme. These two inhibitors are structural components of the parkinsonogenic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). By extension, dopamine and neuromelanin synthesis in the brain may be influenced by the inhibitory effects of such compounds upon the copper-dependent steps of tyrosine metabolism. The non-animal model used in this study may represent an alternative to the use of animal tissues in neurodegenerative disease research.