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Drug-Target Interaction

Drug

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PubChem ID:10141
Structure:
Synonyms:
1,4-Naphthalenedione, 5,8-dihydroxy-
1,4-Naphthalenedione, 5,8-dihydroxy- (9CI)
1,4-Naphthoquinone, 5,8-dihydroxy-
37790_FLUKA
388513_ALDRICH
475-38-7
5,8-Dihydroxy-1,4-naphthalenedione
5,8-Dihydroxy-1,4-naphthoquinone
5,8-Dihydroxy-1,4-naphthosemiquinone
5,8-dihydroxynaphthalene-1,4-dione
5,8-Dihydroxynaphthaquinone
5,8-Dihydroxynaphthoquinone
5,8-dioxy-1,4-naphthoquinone
AC1L1UKT
AC1Q6B9J
AIDS-005214
AIDS005214
AR-1G6408
C005503
C01938
C10H6O4
CCRIS 6670
CHEBI:108908
CHEMBL274056
CID10141
D2070
DHNQ
Dihydroxynaphthoquinone
EINECS 207-495-4
I14-7005
LS-95637
MolPort-001-789-071
NAPHTHAZALIN
Naphthazarin
Naphthazarine
Naphthazarone
NAPTHAZARIN NPHZ
NCI60_002143
NQ-2
NSC 26647
NSC26647
NSC344555
RQNVIKXOOKXAJQ-UHFFFAOYSA-
SBB068464
ZINC00901191

Target

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Uniprot ID:ICE_DROME
Synonyms:
Caspase
drICE
EC-Numbers:3.4.22.-
Organism:Drosophila melanogaster
Fruit fly
PDB IDs:-

Binding Affinities:

Ki: Kd:Ic 50:Ec50/Ic50:
----

References:

10620358
Inhibition of cathepsin D prevents free-radical-induced apoptosis in rat cardiomyocytes.. K Ollinger (2000) Archives of biochemistry and biophysics display abstract
Apoptosis was inhibited in rat cardiomyocytes pretreated with the aspartic protease inhibitor pepstatin A and subsequently exposed to naphthazarin (5,8-dihydroxy-1,4-naphthoquinone). Cathepsin D was released from lysosomes to the cytosol upon exposure to naphthazarin, and the enzyme activity decreased simultaneously. Later, cathepsin D reappeared in granules of increased size, and enzyme activity was restored. Activation of caspase-3-like proteases was detected, and the number of cells showing apoptotic morphology increased with time. Pepstatin A pretreatment did not prevent release of cathepsin D from lysosomes but did significantly inhibit subsequent naphthazarin-induced caspase activation and apoptotic morphology. This suggests that cathepsin D exerts its apoptosis-stimulating effect upstream of caspase-3-like activation.