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Name:Bortezomib
PubChem ID:93860
Pathway:Show KEGG pathways
InChI:InChI=1/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m1/s1/f/h23-24H
SMILES:CC(C)C[C@H](B(O)O)NC([C@H](Cc1ccccc1)NC(c1cnccn1)=O)=O

Properties:
Formula:C19H25BN4O4Atoms:28
Molecular Weight:384.237Rotatable Bonds:11
H-bond Acceptors:8H-bond Donors:0
logP:1.5623
Targets:
NameUniprot IDSourceReferencesInteraction
26S proteasome non-ATPase regulatory subunit 1PSMD1_HUMANDrugBank-shows
26S proteasome non-ATPase regulatory subunit 2PSMD2_HUMANDrugBank-shows
CaspaseICE_DROMEPROMISCUOUSPMID 15217830shows
Cytochrome P450 1A1CP1A1_HUMANSuperCyp-shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 15764713shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 15764713shows
Cytochrome P450 2C8CP2C8_HUMANSuperCyp-shows
Cytochrome P450 2C9CP2C9_HUMANSuperCypPMID 15764713shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 15764713shows
Cytochrome P450 3A4CP3A4_HUMANSuperCypPMID 15764713shows
Mitogen-activated protein kinase 1MK01_HUMANPROMISCUOUSPMID 16546981shows
Mitogen-activated protein kinase 1Q1HBJ4_HUMANPROMISCUOUSPMID 16546981shows
Mitogen-activated protein kinase 1Q499G7_HUMANPROMISCUOUSPMID 16546981shows
Nuclear factor NF-kappa-B p100 subunitNFKB2_HUMANSuperTarget-shows
Nuclear factor NF-kappa-B p105 subunitNFKB1_HUMANSuperTarget-shows
PH and SEC7 domain-containing protein 1PSD1_HUMANSuperTarget-shows
PH and SEC7 domain-containing protein 2PSD2_HUMANSuperTarget-shows
Prostate-specific antigenKLK3_HUMANPROMISCUOUSPMID 15526229shows
Prostate-specific antigenKLK3_MACFAPROMISCUOUSPMID 15526229shows
Prostate-specific antigenKLK3_MACMUPROMISCUOUSPMID 15526229shows
Proteasome subunit alpha type-2PSA2_HUMANSuperTargetPMID 16234364shows
Proteasome subunit beta type-1PSB1_HUMANDrugBank-shows
Proteasome subunit beta type-2PSB2_HUMANDrugBank-shows
Proteasome subunit beta type-5PSB5_HUMANDrugBank-shows
Transcription factor p65TF65_HUMANSuperTarget-shows
Synonyms:
((1R)-3-Methyl-1-(((2S)-3-phenyl-2-((pyrazinylcarbonyl)amino)propanoyl)amino)butyl)boronic acid
179324-69-7
197730-97-5
Boronic acid,
Boronic acid, ((1R)-3-methyl-1-(((2S)-1-oxo-3-phenyl-2-((pyrazinylcarbonyl)amino)propyl)amino)butyl)-
Boronic acid, (3-methyl-1-((1-oxo-3-phenyl-2-((pyrazinylcarbonyl)amino)propyl)amino)butyl)-, (S-(R*,S*))-
Bortezomib
Bortezomib [USAN:INN]
DB00188
LDP 341
LS-45152
MG 341
MLN-341
N-((1S)-1-Benzyl-2-(((1R)-1-(dihydroxyboranyl)-3-methylbutyl)amino)-2-oxoethyl)pyrazinecarboxamide
N-((1S)-1-benzyl-2-(((1R)-1-(dihydroxyboranyl)-3-methylbutyl)amino)2-oxoethylpyrazinecarboxamide
NCGC00168751-01
NSC 681239
Ps 341
PS 341 (pharmaceutical)
PS-341
Velcade
[(1S)-3-methyl-1-[[(2R)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid
ATC-Codes:
Side-Effects:
Side-EffectFrequency
diarrhea0.25777435
thrombocytopenia0.23198372
nausea0.22046134
peripheral neuropathy0.1804772
vomiting0.17805077
constipation0.14876074
anemia0.14872852
pyrexia0.12964725
neutropenia0.1256191
anorexia0.121853106
headache0.10995067
arthralgia0.0948449
insomnia0.0939306
cough0.09226433
pain in limb0.09156194
paresthesia0.09006605
dysesthesia0.090066046
upper respiratory tract infection0.0899125
dehydration0.0833335
dyspnea0.074871294
dizziness0.07291497
anxiety0.0701755
nasopharyngitis0.067976
rash0.06785051
muscle cramps0.06596617
dyspepsia0.0657895
bone pain0.058520827
back pain0.057784658
pruritus0.0570175
myalgia0.055298325
edema0.053735647
abdominal pain0.05294372
hypotension0.05116957
vertigo0.048943315
herpes zoster0.04676061
vision blurred0.036883
pneumonitis0.0283652
infection0.020918757
mediastinal disorders0.0010
paraplegia0.0010
acute psychosis0.0010
pericardial effusion0.0010
pericarditis0.0010
gastritis hemorrhagic0.0010
sepsis0.0010
hypoxia0.0010
petechiae0.0010
phlebitis0.0010
pleural effusion0.0010
aspiration pneumonia0.0010
postherpetic neuralgia0.0010
lung infiltration0.0010
ileus paralytic0.0010
pancreatitis0.0010
melena0.0010
meningoencephalitis0.0010
multiple myeloma0.0010
hearing impaired0.0010
myocardial infarction0.0010
respiratory failure0.0010
hyperuricemia0.0010
tumour0.0010
nephrotic syndrome0.0010
neuralgia0.0010
peritonitis0.0010
palsy0.0010
pain0.0010
bradycardia0.0010
psychotic disorder0.0010
pulmonary embolism0.0010
portal vein thrombosis0.0010
urinary incontinence0.0010
urinary tract infection0.0010
urticaria0.0010
vascular disorders0.0010
myocardial ischemia0.0010
atrioventricular block complete0.0010
leukocytoclastic vasculitis0.0010
ventricular tachycardia0.0010
deep venous thrombosis0.0010
virus infection0.0010
agitation0.0010
liver failure0.0010
encephalopathy0.0010
ischemic colitis0.0010
erythema0.0010
toxoplasmosis0.0010
renal failure0.0010
acute respiratory distress syndrome0.0010
seizures0.0010
shock0.0010
septic shock0.0010
sinusitis0.0010
small intestinal obstruction0.0010
spasm0.0010
stomatitis0.0010
stroke0.0010
subarachnoid hemorrhage0.0010
tachycardia0.0010
dyspnea exertional0.0010
sinus arrest0.0010
urinary retention0.0010
lymphopenia0.0010
pancreatitis acute0.0010
confusion0.0010
cystitis0.0010
deafness0.0010
dysphagia0.0010
diplopia0.0010
drug hypersensitivity0.0010
duodenitis0.0010
dysarthria0.0010
embolism0.0010
toxic epidermal necrolysis0.0010
grand mal convulsion0.0010
epistaxis0.0010
fecal impaction0.0010
gastroenteritis0.0010
gastroesophageal reflux0.0010
bilateral hearing loss0.0010
cardiac disorders0.0010
coma0.0010
acute pulmonary edema0.0010
amyloidosis0.0010
anaphylactic reaction0.0010
angina pectoris0.0010
angioedema0.0010
ascites0.0010
aspergillosis0.0010
ataxia0.0010
atelectasis0.0010
atrial fibrillation0.0010
atrial flutter0.0010
bacteremia0.0010
malignancies0.0010
oral candidiasis0.0010
cardiac tamponade0.0010
renal tubular acidosis0.0010
cerebral hemorrhage0.0010
transient ischemic attack0.0010
heart failure0.0010
pulmonary hypertension0.0010
herpes0.0010
calculus renal0.0010
hypokalemia0.0010
herpes simplex0.0010
ophthalmic herpes simplex0.0010
hydronephrosis0.0010
hyperbilirubinemia0.0010
hypocalcemia0.0010
hyperkalemia0.0010
hypernatremia0.0010
inappropriate adh secretion0.0010
hyponatremia0.0010
hypersensitivity0.0010
intestinal perforation0.0010
acute renal failure0.0010
bleeding0.0010
hepatitis0.0010
hematemesis0.0010
subdural hematoma0.0010
chronic obstructive airways disease0.0010
pulmonary disease0.0010
hematuria0.0010
leukopenia0.0010
hemoptysis0.0010
lightheadedness0
chest wall pain0
ischemia0
sterility0
autonomic neuropathy0
polyarthritis0
joint stiffness0
asthenia0
malaise0
postural hypotension0
arrhythmia0
abdominal pain upper0
leukemia0
infertility0
neuropathy0
musculoskeletal pain0
meningitis0
numbness0
hypercalcemia0
skin irritation0
hyperglycemia0
congestive heart failure0
ureteral obstruction0
failure to thrive0
fatigue0
flushing0
syncope0
swelling0
gastritis0
pulmonary edema0
gastrointestinal hemorrhage0
enteritis0
vasculitis0
venous thrombosis0
hypertension0
hypomagnesemia0
weakness0
connective tissue disorders0
hypophosphatemia0
hypochloremia0
peripheral edema0
constitutional symptoms0
burning sensation0
acute febrile neutrophilic dermatosis0
weight loss0
cardiac arrest0