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Name:Rosigilitazone
PubChem ID:77999
Pathway:Show KEGG pathways
InChI:InChI=1/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)/f/h20H
SMILES:CN(CCOc1ccc(cc1)CC1C(NC(=O)S1)=O)c1ccccn1

Properties:
Formula:C18H19N3O3SAtoms:25
Molecular Weight:357.427Rotatable Bonds:7
H-bond Acceptors:5H-bond Donors:0
logP:2.8197
Targets:
NameUniprot IDSourceReferencesInteraction
Caspase-3CASP3_HUMANPROMISCUOUSPMID 16777971shows
Caspase-3CASP3_MOUSEPROMISCUOUSPMID 18560759shows
CREB3L2-PPARgammaQ86WD1_HUMANSuperTargetPMID 016137931shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 12642470shows
Cytochrome P450 2A6CP2A6_HUMANSuperCypPMID 12642470shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 12642470shows
Cytochrome P450 2C8CP2C8_HUMANSuperTargetPMID 016027405shows
Cytochrome P450 2C9CP2C9_HUMANSuperCypPMID 10510156shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 12642470shows
Cytochrome P450 3A4CP3A4_HUMANPROMISCUOUSPMID 15860655shows
Matrix metalloproteinase-9MMP9_MOUSEPROMISCUOUSPMID 19201691shows
Mitogen-activated protein kinase 1MK01_RATPROMISCUOUSPMID 16155101shows
Nitric oxide synthaseQ62710_RATPROMISCUOUSPMID 14709329shows
Nitric oxide synthase, brainNOS1_MOUSEPROMISCUOUSPMID 18560759shows
Nitric oxide synthase, brainNOS1_RATPROMISCUOUSPMID 14709329shows
Nitric oxide synthase, endothelialNOS3_MOUSEPROMISCUOUSPMID 18560759shows
Nitric oxide synthase, endothelialNOS3_RATPROMISCUOUSPMID 14709329shows
Nitric oxide synthase, inducibleNOS2_MOUSEPROMISCUOUSPMID 18560759shows
Nitric oxide synthase, inducibleNOS2_RATPROMISCUOUSPMID 14709329shows
Peroxisome proliferative activated receptor gammaQ4W448_HUMANSuperTargetPMID 016137931shows
Peroxisome proliferative activated receptor gammaQ4W4C6_HUMANSuperTargetPMID 016137931shows
Peroxisome proliferative activated receptor gammaQ4W4C7_HUMANSuperTargetPMID 016137931shows
Peroxisome proliferative activated receptor gamma isoform 2 variantQ53EW1_HUMANSuperTargetPMID 016137931shows
Peroxisome proliferator activated-receptor gammaQ9UEF6_HUMANSuperTargetPMID 016137931shows
Peroxisome proliferator-activated receptor alphaPPARA_HUMANBindingDB-shows
Peroxisome proliferator-activated receptor deltaPPARD_HUMANBindingDB-shows
Peroxisome proliferator-activated receptor gammaPPARG_HUMANBindingDB-shows
Peroxisome proliferator-activated receptor gamma 1Q6L9M1_HUMANSuperTargetPMID 016137931shows
Prostaglandin G/H synthase 2PGH2_RATPROMISCUOUSPMID 12897060shows
Protein kinase cB8LXH5_TALSNPROMISCUOUSPMID 16672634shows
Protein kinase CKPC1_LYTPIPROMISCUOUSPMID 16672634shows
Protein kinase CKPC3_DROMEPROMISCUOUSPMID 16672634shows
Testicular acid phosphatasePPAT_HUMANSuperTarget-shows
Tyrosine-protein phosphatase non-receptor type 1PTN1_HUMANBindingDB-shows
Synonyms:
122320-73-4
2,4-Thiazolidinedione,
2,4-Thiazolidinedione, 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-
2,4-Thiazolidinedione, 5-004-02-((((methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-
2,4-thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-
2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]- (9CI)
5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-((4-(2-Methyl-2-(pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione-2-butenedioate
5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione
5-[4-[2-(N-Methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione
5-[[4-[2-(methyl-(2-pyridyl)amino)ethoxy]phenyl]methyl] thiazolidine-2,4-dione
5-[[4-[2-(methyl-pyridin-2-ylamino)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
Avandaryl
Avandia
BB_SC-4138
Brl 49653
Brl-49653
BRL49653
BSPBio_002693
C18H19N3O3S
CHEBI:50122
DB00412
IDMB (1uM BRL49653, 1uM Dexamethasone, 0.5uM IBMX, 10ug/mL Insulin)
KBio2_002183
KBio2_004751
KBio2_007319
KBio3_001913
KBioGR_001609
KBioSS_002183
LS-151340
NCGC00095124-01
NCGC00095124-02
NCGC00095124-03
RGZ
Rosi
Rosigilitazone
Rosigliazone maleate
Rosiglitazone
rosiglitazone (Avandia)
Rosiglitazone maleate
Rosiglitazone [INN:BAN]
Rosiglizole
RSG
S00306
SPBio_001142
SPECTRUM1504263
Spectrum2_001241
Spectrum3_000997
Spectrum4_001125
Spectrum5_001464
Spectrum_001703
TDZ 01
[3H]rosiglitazone
ATC-Codes:
Side-Effects:
Side-EffectFrequency
abdominal pain0.0010
hyperbilirubinemia0.0010
hyperglycemia0.0010
hypoglycemia0.0010
influenza0.0010
nasopharyngitis0.0010
nausea0.0010
pain0.0010
pleural effusions0.0010
pruritus0.0010
pulmonary edema0.0010
sinusitis0.0010
stevens - johnson syndrome0.0010
upper respiratory tract infection0.0010
urticaria0.0010
vomiting0.0010
hepatic failure0.0010
hepatitis0.0010
congestive heart failure0.0010
cardiac failure0.0010
anaphylactic reaction0.0010
anemia0.0010
angioedema0.0010
back pain0.0010
cough0.0010
type 2 diabetes0.0010
diabetic ketoacidosis0.0010
diarrhea0.0010
dizziness0.0010
dysmenorrhea0.0010
headache0.0010
edema0.0010
rash0.0010
weight gain0
fatigue0
hypertension0
arthralgia0
constipation0
myocardial infarction0
myocardial ischemia0