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Drug Details

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Name:Methylaminopterinum
PubChem ID:72440
Pathway:Show KEGG pathways
InChI:InChI=1/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/t13-/m1/s1/f/h25,29,32H,21-22H2
SMILES:CN(Cc1cnc2c(c(N)nc(N)n2)n1)c1ccc(cc1)C(N[C@@H](CCC(O)=O)C(O)=O)=O

Properties:
Formula:C20H22N8O5Atoms:33
Molecular Weight:454.439Rotatable Bonds:10
H-bond Acceptors:12H-bond Donors:0
logP:1.8217
Targets:
NameUniprot IDSourceReferencesInteraction
ABC transporter MOAT-B isoformO75555_HUMANSuperTargetPMID 014643890shows
ABCC3 proteinQ86VN9_HUMANSuperTargetPMID 010329726shows
ABCC3 proteinQ86X85_HUMANSuperTargetPMID 010329726shows
ABCC4 proteinQ8IVZ4_HUMANSuperTargetPMID 014643890shows
ABCC4 protein variantQ59GY6_HUMANSuperTargetPMID 014643890shows
ATP-binding cassette subfamily C member 4 variant 1Q8IUA3_HUMANSuperTargetPMID 014643890shows
ATP-binding cassette, sub-family C (CFTR/MRP), member 2Q5TCZ5_HUMANSuperTargetPMID 010727523shows
ATP-binding cassette, sub-family C, member 3 isoform MRP3 variantQ59H05_HUMANSuperTargetPMID 010329726shows
Bifunctional purine biosynthesis protein PURHPUR9_HUMANBindingDB-shows
Canalicular multispecific organic anion transporter 1MRP2_HUMANSuperTargetPMID 010727523shows
Canalicular multispecific organic anion transporter 2MRP3_HUMANSuperTargetPMID 010329726shows
Dihydrofolate reductaseDYR_CHICKBindingDB-shows
Dihydrofolate reductaseDYR_ECOLIBindingDB-shows
Dihydrofolate reductaseDYR_HUMANBindingDB-shows
Dihydrofolate reductaseDYR_LACCABindingDB-shows
Dihydrofolate reductaseDYR_PNECABindingDB-shows
Folate transporter 1S19A1_HUMANBindingDB-shows
Folylpolyglutamate synthaseQ5JU19_HUMANSuperTargetPMID 003190739shows
Folylpolyglutamate synthase, mitochondrialFOLC_HUMANBindingDB-shows
Folylpolyglutamate synthase, mitochondrialFOLC_MOUSEBindingDB-shows
Gamma-glutamyl hydrolaseGGH_HUMANSuperTargetPMID 011389096shows
Glutamate dehydrogenase isoform IQ9TQQ9_BOVINPROMISCUOUSPMID 178372shows
Glutamate dehydrogenase isoform IIQ9TR40_BOVINPROMISCUOUSPMID 178372shows
Multidrug resistance associated proteinQ96QA9_HUMANSuperTargetPMID 010329726shows
Multidrug resistance protein 1MDR1_HUMANSuperTargetPMID 010075817shows
Multidrug resistance protein 1 variantQ59GY9_HUMANSuperTargetPMID 010075817shows
Multidrug resistance-associated protein 4MRP4_HUMANSuperTargetPMID 014643890shows
P-glycoproteinO60213_HUMANSuperTargetPMID 010075817shows
P-glycoprotein 1Q6TBL4_HUMANSuperTargetPMID 010075817shows
Serum albuminALBU_HUMANDrugBank-shows
Thymidylate synthaseTYSY_HUMANBindingDB-shows
Thymidylate synthaseTYSY_LACCABindingDB-shows
Thymidylate synthaseTYSY_MOUSEBindingDB-shows
Trifunctional purine biosynthetic protein adenosine-3PUR2_HUMANBindingDB-shows
Synonyms:
15475-56-6
4-Amino-10-methylfolic acid
4-Amino-N(sup 10)-methylpteroylglutamic acid
4-Aminomethylpteroylglutamic acid
51865-79-3
59-05-2
7413-34-5
A-Methopterin
A-Methpterin
AI3-25299
AIDS-006953
AIDS006953
Amethopterin L-
Antifolan
C20H22N8O5
CAS-59-05-2
CAS-59-05-2-Batch2
CCRIS 1109
CL-14377
D-(-)-N-(2,4-Diamino-6-pteridinyl(dimethylamino)benzoyl)glutamic acid
D-Amethopterin
D-glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)-
D-Glutamic acid, N-[4-[[(2,4-diamino-6- pteridinyl)methyl][methyl]amino]benzoyl]-
D-Methotrexate
DRG-0024
EINECS 200-413-8
EINECS 257-482-2
EMT 25,299
Folex-Pfs
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D-
Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, L-
Hdmtx
HSDB 3123
Kyselina 4-amino-N(sup 10)-methylpteroylglutamova [Czech]
Kyselina N-(p-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)-L-glutamova [Czech]
l-()-n-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid
L-(+)-N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)glutamic acid
L-Glutamic acid, N-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-
Ledertrexate
Lopac-A-6770
Lopac-A-9898
Lopac0_000095
LS-71810
Metatrexan
Methotrexat-Ebewe
METHOTREXATE
Methotrexate analog
Methotrexate [USAN:BAN:INN:JAN]
Methotrexate, (D)-Isomer
Methotrexate, L-
Methotrexatum
Methotrexatum [INN-Latin]
Methylaminopterinum
Metotressato [DCIT]
Metotrexato
Metotrexato [INN-Spanish]
Mexate
MTX
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-D-glutamic acid
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamicacid
n-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-l-()-glutamic acid
N-(p-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-(+)-glutamic acid
N-(p-(((2,4-Diamino-6-pteridyl)methyl)methylamino)benzoyl)glutamic acid
N-Bismethylpteroylglutamic acid
NCGC00015079-01
NCGC00015079-02
NCGC00016264-01
NCGC00016264-02
NCI-C04671
NSC 117356
NSC 740
NSC-740
NSC117356
R 9985
Rheumatrex
TCMDC-125488
X 133
ATC-Codes: