Drug Details

Name:	Zoledronate
PubChem ID:	68740
Pathway:	Show KEGG pathways
InChI:	InChI=1/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)/f/h9-10,12-13H
SMILES:	c1cn(CC(O)(P(O)(O)=O)P(O)(O)=O)cn1
Properties:	Formula: C5H10N2O7P2 Atoms: 16 Molecular Weight: 272.09 Rotatable Bonds: 4 H-bond Acceptors: 8 H-bond Donors: 0 logP: -1.1154
Targets:	Name Uniprot ID Source References Interaction Caspase ICE_DROME PROMISCUOUS PMID 15286715 shows Farnesyl pyrophosphate synthetase FPPS_HUMAN BindingDB - shows Geranylgeranyl pyrophosphate synthetase GGPPS_HUMAN BindingDB - shows enlarge table
Synonyms:	(1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid (1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid (1-hydroxy-2-imidazol-1-yl-phosphonoethyl)phosphonic acid monohydrate (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid 118072-93-8 2-(imidazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid AC-1092 AC1L2ACJ AC1Q6RN3 Aclasta AKOS005145739 BIDD:GT0292 BIDD:PXR0134 Bio-0112 Bisphosphonate 3 C088658 CGP 42'446 CGP 42446 CGP 42446A CGP-42'446 CGP-42446 CHEBI:46557 CHEMBL924 D08689 DB00399 FT-0082657 HMS2089O09 I06-0710 KS-1132 LS-181815 NCGC00159521-02 NCGC00159521-03 Novartis brand of zoledronic acid NSC721517 Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis- Phosphonic acid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- Reclast Reclast (TN) S00092 S1314_Selleck STOCK1N-71622 UNII-70HZ18PH24 ZOL Zoledronate Zoledronic acid Zoledronic acid (INN) Zoledronic acid [USAN:INN] Zoledronic Acid-Supplied by Selleck Chemicals Zometa Zometa (Novartis) Zometa (TN) Zometa Concentrate Zometa, Zomera, Aclasta and Reclast, Zoledronic Acid [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) enlarge table
ATC-Codes:	M05BA08 enlarge table
Side-Effects:	Side-Effect Frequency constipation 0.21333335 nausea 0.19399999 dyspnea 0.18 cough 0.17 insomnia 0.155 arthralgia 0.14359999 bone pain 0.14183335 hypophosphatemia 0.13952382 diarrhea 0.13049999 agitation 0.13 hyperthermia 0.12711112 anxiety 0.125 hypokalemia 0.12 neutropenia 0.12 moniliasis 0.12 alopecia 0.12 headache 0.11575 vomiting 0.112 dermatitis 0.11 abdominal pain 0.10666668 thrombocytopenia 0.1 confusion 0.099999994 dizziness 0.09150001 fatigue 0.09116667 paresthesia 0.085 weakness 0.08066667 stomatitis 0.08 vertigo 0.078666665 pain in extremity 0.07825 myalgia 0.078 osteoarthritis 0.074 anemia 0.07244444 edema 0.07066666 influenza 0.069 urinary tract infection 0.0655 hypertension 0.06533334 back pain 0.063666664 anorexia 0.057 hypotension 0.0555 dyspepsia 0.0525 peripheral edema 0.043666665 weight decreased 0.04075 asthenia 0.035 shoulder pain 0.0345 chills 0.0345 upper respiratory tract infection 0.033999998 malignant neoplasm 0.033545457 pain 0.03266667 rash 0.03 dehydration 0.029000001 neck pain 0.029 sore throat 0.027333334 atrial fibrillation 0.026 muscle spasms 0.026 abdominal pain upper 0.021666666 hypomagnesemia 0.020000001 abdominal distension 0.02 chest pain 0.0185 malaise 0.0155 hypermagnesemia 0.012 musculoskeletal pain 0.011999999 hypocalcemia 0.011666666 allergic reaction 0.0010 hyperesthesia 0.0010 hypercalcemia 0.0010 hematuria 0.0010 episcleritis 0.0010 coagulopathies 0.0010 angioedema 0.0010 blurred vision 0.0010 bradycardia 0.0010 osteonecrosis 0.0010 breast cancer 0.0010 increased sweating 0.0010 anaphylactic reaction 0.0010 syncope 0.0010 hyperkalemia 0.0010 hypernatremia 0.0010 shock 0.0010 scleritis 0.0010 renal failure 0.0010 proteinuria 0.0010 tremor 0.0010 neoplasms 0.0010 uveitis 0.0010 muscle cramps 0.0010 multiple myeloma 0.0010 weight increase 0.0010 infection 0.0010 dry mouth 0.0010 hypersensitivity 0.0010 liver function tests abnormal 0 swelling 0 epigastric pain 0 heart disease 0 mediastinal disorders 0 agranulocytosis 0 asthma 0 pancytopenia 0 dysphagia 0 cataract 0 somnolence 0 avascular necrosis 0 periodontal disease 0 kidney carcinoma 0 hallucinations 0 lymphoma 0 acute renal failure 0 chronic renal failure 0 pruritus 0 urticaria 0 cachexia 0 conjunctivitis 0 pleural effusion 0 flushing 0 leukopenia 0 gingivitis 0 malnutrition 0 nasopharyngitis 0 osteomyelitis 0 iritis 0 mouth ulceration 0 vascular disorders 0 azotemia 0 enlarge table

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