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Name:Efavirenz
PubChem ID:64139
Pathway:Show KEGG pathways
InChI:InChI=1/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1/f/h19H
SMILES:C1CC1C#C[C@]1(c2cc(ccc2NC(=O)O1)Cl)C(F)(F)F

Properties:
Formula:C14H9ClF3NO2Atoms:21
Molecular Weight:315.675Rotatable Bonds:1
H-bond Acceptors:6H-bond Donors:0
logP:4.2111
Targets:
Synonyms:
(-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
(-)-Efavirenz
(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one
(4S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
(4S)-6-Chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1
(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
154598-52-4
154635-17-3 (RACEMATE)
1ikv
1ikw
2H-3,1-Benzoxazin-2-one, 6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)-
AIDS-032934
AIDS-106821
AIDS032934
AIDS106821
C08088
C14H9ClF3NO2
CHEBI:119486
CPD000466351
D00896
DB00625
DMP 266
DMP-266
Efavirenz
Efavirenz (JAN/INN)
efavirenz, (S)-isomer
EFV
EFZ
HSDB 7163
L 743726
L-741211
L-743,726
L-743725
L-743726
LS-173464
Met-SDF-1.beta. & Efavirenz
Met-Stromal Cell-derived Factor-1.beta. (Human) & Efavirenz
MLS000759465
MLS001424087
NSC742403
SAM001246667
SMR000466351
Stocrin
Strocin (TM)
Sustiva
Sustiva (TM)
Sustiva (TN)
ZINC02020233
ATC-Codes:
Side-Effects:
Side-EffectFrequency
rash0.106603764
dizziness0.06
pruritus0.05
abdominal pain0.03
diarrhea0.03
anorexia0.02
nausea0.02
fatigue0.02
headache0.02
pain0.015749998
iritis0.0010
palpitations0.0010
hypercholesterolemia0.0010
muscle weakness0.0010
neurosis0.0010
neuralgia0.0010
polyarthritis0.0010
hypersensitivity reaction0.0010
hypertriglyceridemia0.0010
myalgia0.0010
myopathy0.0010
hypertension0.0010
influenza0.0010
malabsorption0.0010
malaise0.0010
jaundice0.0010
nail disorders0.0010
pancreatitis0.0010
thrombocytopenia0.0010
thrombophlebitis0.0010
tinnitus0.0010
tremor0.0010
allergic reaction0.0010
urticaria0.0010
abnormal vision0.0010
agitation0.0010
verruca0.0010
dry mouth0.0010
tachycardia0.0010
syncope0.0010
pancytopenia0.0010
paresis0.0010
paresthesia0.0010
migraine headaches0.0010
peripheral edema0.0010
polyuria0.0010
proteinuria0.0010
psychosis0.0010
rhabdomyolysis0.0010
stevens - johnson syndrome0.0010
hepatic failure0.0010
hepatomegaly0.0010
alopecia0.0010
confusion0.0010
constipation0.0010
convulsions0.0010
increased sweating0.0010
delirium0.0010
acne0.0010
neuropathy0.0010
dermatitis0.0010
chest pain0.0010
peripheral neuropathy0.0010
paranoia0.0010
amnesia0.0010
anemia0.0010
anxiety0.0010
apnea0.0010
arthralgia0.0010
asthenia0.0010
asthma0.0010
ataxia0.0010
photosensitivity0.0010
diplopia0.0010
flushing0.0010
folliculitis0.0010
arrhythmia0.0010
gynecomastia0.0010
hallucination0.0010
congestive heart failure0.0010
hepatitis0.0010
hepatitis b0.0010
glaucoma0.0010
flank pain0.0010
blurred vision0.0010
fever0.0010
hepatitis c antibody positive0.0010
dyspnea0.0010
erythema nodosum0.0010
erythema multiforme0.0010
eczema0.0010
lightheadedness0
elevated liver enzymes0
thinking abnormal0
apathy0
emotional lability0
concentration impaired0
manic0
insomnia0
erythema0
stupor0
vomiting0
dyspepsia0
somnolence0
exfoliative dermatitis0
depersonalization0
delusions0
cough0
cleft palate0
cachexia0
blistering0
toxic epidermal necrolysis0
euphoria0
hiv infection0
ulcer0
tuberculosis0
pneumonia0
lipoma0
obesity0
nervousness0
cancer0
lipodystrophy0
breast enlargement0
malformations0