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Name:Ziprasidone hydrochloride
PubChem ID:60854
Pathway:Show KEGG pathways
InChI:InChI=1/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)/f/h23H
SMILES:c1ccc2c(c1)c(ns2)N1CCN(CCc2cc3CC(Nc3cc2Cl)=O)CC1

Properties:
Formula:C21H21ClN4OSAtoms:28
Molecular Weight:412.936Rotatable Bonds:4
H-bond Acceptors:4H-bond Donors:0
logP:3.9499
Targets:
NameUniprot IDSourceReferencesInteraction
5-hydroxytryptamine (Serotonin) receptor 1AQ5ZGX3_HUMANSuperTargetPMID 010516958shows
5-hydroxytryptamine (Serotonin) receptor 2AQ9P2Q9_HUMANSuperTargetPMID 007562537shows
5-hydroxytryptamine receptor 1A5HT1A_HUMANBindingDB-shows
5-hydroxytryptamine receptor 1D5HT1D_HUMANDrugBank-shows
5-hydroxytryptamine receptor 2A5HT2A_HUMANBindingDB-shows
5-hydroxytryptamine receptor 2C5HT2C_HUMANBindingDB-shows
5-hydroxytryptamine receptor 65HT6R_HUMANBindingDB-shows
5-hydroxytryptamine receptor 75HT7R_HUMANDrugBank-shows
Alpha-1A adrenergic receptorADA1A_HUMANDrugBank-shows
Alpha-1D adrenergic receptorADA1D_HUMANBindingDB-shows
Alpha-2C adrenergic receptorADA2C_HUMANBindingDB-shows
Beta-1 adrenergic receptorADRB1_HUMANDrugBank-shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 010771452shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 010771452shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 010771452shows
Cytochrome P450 1A2CP1A2_HUMANSuperCyp-shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 10771452shows
Cytochrome P450 3A4CP3A4_HUMANSuperTargetPMID 010771452shows
Cytochrome P450 3A5CP3A5_HUMANSuperCyp-shows
Cytochrome P450 3A7CP3A7_HUMANSuperCyp-shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 010771452shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 010771452shows
D(1A) dopamine receptorDRD1_HUMANBindingDB-shows
D(2) dopamine receptorDRD2_HUMANBindingDB-shows
D(2) dopamine receptorDRD2_RATBindingDB-shows
D(3) dopamine receptorDRD3_HUMANBindingDB-shows
D(4) dopamine receptorDRD4_HUMANBindingDB-shows
Histamine H1 receptorHRH1_HUMANBindingDB-shows
Muscarinic acetylcholine receptor M1ACM1_HUMANBindingDB-shows
Potassium voltage-gated channel subfamily H member 2KCNH2_HUMANBindingDB-shows
Sodium-dependent serotonin transporterSC6A4_HUMANBindingDB-shows
Synonyms:
138982-67-9
146939-27-7
2H-Indol-2-one,
2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-
5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-4-chloroisoindolin-1-one
5-{2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl}-6-chloro-1,3-dihydro-2H-indol-2-one
6-chloro-5-[2-[4-(7-thia-8-azabicyclo[4.3.0]nona-1,3,5,8-tetraen-9-yl)piperazin-1-yl]ethyl]-1,3-dihydroindol-2-one
Ambap6301
C07568
C21H21ClN4OS
CHEBI:10119
CID60854
CP 88059
CP 88059-01
CP-88,059
CP-88,059-01
CP-88,059-1
CPD000466328
DB00246
Geodon
LS-83744
MLS000759435
SAM001246607
SMR000466328
TL8000889
Zeldox
Ziprasidone
Ziprasidone hydrochloride
Ziprasidone mesylate trihydrate
Ziprasidone [INN:BAN]
ziprazidone
ATC-Codes:
Side-Effects:
Side-EffectFrequency
amnesia1.0
hypothermia1.0
chills1.0
confusion1.0
delirium1.0
ataxia1.0
flank pain1.0
choreoathetosis1.0
fever1.0
photosensitivity1.0
neuropathy1.0
dysarthria1.0
abnormal gait1.0
diplopia1.0
vertigo1.0
tremor0.82777774
dyskinesia0.82777774
dyspnea0.44625002
agitation0.41764706
abdominal pain0.41764706
flu syndrome0.41470596
fungal dermatitis0.3671429
myalgia0.3642857
hypertension0.3295455
postural hypotension0.3089412
edema0.30254176
vomiting0.28769237
tachycardia0.28577778
anorexia0.27052632
paresthesia0.23213635
somnolence0.15749998
schizophrenia0.14
lightheadedness0.12
headache0.10958332
dizziness0.08699999
nausea0.08250001
pain0.080000006
paralysis0.071428575
infection0.057777777
constipation0.04578947
dyspepsia0.040833324
abnormal vision0.03785714
asthenia0.032083336
diarrhea0.029473685
anxiety0.026842108
chest pain0.025555555
dry mouth0.024166668
increased salivation0.02222222
rash0.021777775
cough0.02111111
pharyngitis0.02111111
rhinitis0.017368421
insomnia0.012666666
dysphagia0.010624999
sweating0.01
furunculosis0.01
personality disorder0.01
bradycardia0.01
dysmenorrhea0.01
tinnitus0.009999999
urinary retention0.009999999
tenosynovitis0.009999999
polyuria0.009999999
atrial fibrillation0.009999999
impotence0.009999999
blepharitis0.009999999
leukocytosis0.009999999
leukopenia0.009999999
pneumonia0.009999999
lymphadenopathy0.009999999
albuminuria0.009999999
alopecia0.009999999
amenorrhea0.009999999
anemia0.009999999
metrorrhagia0.009999999
angina pectoris0.009999999
menorrhagia0.009999999
conjunctivitis0.009999999
contact dermatitis0.009999999
ecchymosis0.009999999
lactic dehydrogenase increased0.009999999
alkaline phosphatase increased0.009999999
hematuria0.009999999
dehydration0.009999999
exfoliative dermatitis0.009999999
rectal hemorrhage0.009999999
glycosuria0.009999999
epistaxis0.009999999
dry eyes0.009999999
photophobia0.009999999
peripheral edema0.009999999
eczema0.009999999
cataract0.009999999
hyperglycemia0.009999999
hypercholesteremia0.009999999
hypokalemia0.009999999
eosinophilia0.009999999
urticaria0.008874999
sexual dysfunction0.0054999995
back pain0.0050
tooth disorder0.0050
psychosis0.0050
priapism0.0046363636
allergic reaction0.0010
thyroiditis0.0010
thrombophlebitis0.0010
thrombocytopenia0.0010
galactorrhea0.0010
hypochloremia0.0010
vaginal hemorrhage0.0010
thrombocythemia0.0010
hypomagnesemia0.0010
hyperchloremia0.0010
vascular disorders0.0010
uterine hemorrhage0.0010
urinary incontinence0.0010
deep thrombophlebitis0.0010
torticollis0.0010
hyperuricemia0.0010
tardive dyskinesia0.0010
respiratory alkalosis0.0010
gynecomastia0.0010
cardiac disorders0.0010
cardiomegaly0.0010
hematemesis0.0010
hemoptysis0.0010
hemorrhage0.0010
hepatitis0.0010
hepatomegaly0.0010
hyperkalemia0.0010
gout0.0010
gum hemorrhage0.0010
fecal impaction0.0010
hypochromic anemia0.0010
angioedema0.0010
av block0.0010
breast disorders0.0010
bundle branch block0.0010
cerebral infarct0.0010
allergic dermatitis0.0010
enuresis0.0010
fatty liver0.0010
hyperlipemia0.0010
hyperthyroidism0.0010
myopathy0.0010
myocarditis0.0010
nocturia0.0010
nystagmus0.0010
phlebitis0.0010
polycythemia0.0010
pulmonary embolus0.0010
visual field defect0.0010
cerebrovascular accident0.0010
syncope0.0010
melena0.0010
serotonin syndrome0.0010
hypocalcemia0.0010
hypoglycemia0.0010
hyponatremia0.0010
hypothyroidism0.0010
jaundice0.0010
keratitis0.0010
keratoconjunctivitis0.0010
leukoplakia of mouth0.0010
lymphedema0.0010
lymphocytosis0.0010
weight gain0
weight loss0
spasm0
arthralgia0
upper respiratory tract infection0