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Name:SAQUINAVIR
PubChem ID:60787
Pathway:Show KEGG pathways
InChI:InChI=1/C38H50N6O5/c1-38(2,3)43-37(49)32-20-26-14-7-8-15-27(26)22-44(32)23-33(45)30(19-24-11-5-4-6-12-24)41-36(48)31(21-34(39)46)42-35(47)29-18-17-25-13-9-10-16-28(25)40-29/h4-6,9-13,16-18,26-27,30-33,45H,7-8,14-15,19-23H2,1-3H3,(H2,39,46)(H,41,48)(H,42,47)(H,43,49)/t26?,27?,30-,31-,32-,33+/m0/s1/f/h41-43H,39H2
SMILES:CC(C)(C)NC([C@@H]1(CC2CCCCC2CN1C[C@@H]([C@@H](Cc1ccccc1)NC([C@@H](CC(N)=O)NC(c1ccc2ccccc2n1)=O)=O)O))=O

Properties:
Formula:C38H50N6O5Atoms:55
Molecular Weight:670.841Rotatable Bonds:16
H-bond Acceptors:11H-bond Donors:0
logP:4.9033
Targets:
Synonyms:
(2S)-N-[(2S,3R)-4-[(3S)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenylbutan-2-yl]-2-(quinoline-2-carbonylamino)butanediamide
(3S-(2(1R*(R*),2S*),3I,4athetav,8athetav))-N(sup 1)-(3-(3-(((1,1-Dimethylethyl)amino)carbonyl)octahydro-2(1H)-isoquinolinyl)-2-hydroxy-1-(phenylmethyl)propyl)-2-((2-quinolinylcarbonyl)amino)butanediamide
(S)-N-((IS)-I-((1R)-2-((3S,4aS,8aS)-3-(tert-Butylcarbamoyl)octahydro-2(1H)-isoquinolyl)-1-hydroxyethyl)phenethyl)-2-quinaldamidosuccinamide
127779-20-8
149845-06-7
Butanediamide,
Butanediamide, N1-((1S,2R)-3-((3S,4aS,8aS)-3-(((1,1-dimethylethyl)amino)carbonyl)octahydro-2(1H)-isoquinolinyl)-2-hydroxy-1-(phenylmethyl)propyl)-2-((2-quinolinylcarbonyl)amino)-, (2S)-
Butanediamide, N1-(3-(3-(((1,1-dimethylethyl)amino)carbonyl)octahydro-2(1H)-isoquinolinyl)-2-hydroxy-1-(phenylmethyl)propyl)-2-((2-quinolinylcarbonyl)amino)-, (3S-(2(1R*(R*),2S*),3alpha,4aalpha,8aalpha))-
C38H50N6O5
DB01232
Fortovase
HSDB 7161
INVIRASE
LS-45633
Ro 31-8959
Ro 31-8959/000
SAQUINAVIR
Saquinavir Mesylate
Saquinavir [USAN]
Saquinivir
SQV
ATC-Codes:
Side-Effects:
Side-EffectFrequency
ketoacidosis0.0010
hematomas0.0010
hypersensitivity0.0010
hemarthroses0.0010
hypercholesterolemia0.0010
lipodystrophy0.0010
breast hypertrophy0.0010
vascular disorders0.0010
diabetes mellitus0.0008
hyperglycemia0.0008
allergic reactions0.00066
convulsions0.00066
somnolence0.00066
hepatitis0.00066
bleeding0.00066
thrombophlebitis0.00066
hypertriglyceridemia0.00066
pharyngitis0.0
skin nodule0.0
sinusitis0.0
pain pelvic0.0
seizures0.0
poliomyelitis0.0
dermatitis seborrheic0.0
peripheral neuropathy0.0
rhinitis0.0
psychosis0.0
pneumonia0.0
paresthesia0.0
paresis0.0
leucopenia0.0
liver disease0.0
pulmonary disease0.0
melena0.0
cramps0.0
musculoskeletal pain0.0
infection mycotic0.0
nail disorder0.0
neoplasms0.0
pancytopenia0.0
neutropenia0.0
night sweats0.0
numbness0.0
otitis0.0
pain0.0
pancreatitis0.0
progressive multifocal leukoencephalopathy0.0
skin ulceration0.0
spasms0.0
myalgia0.0
vaginal discharge0.0
polyarthritis0.0
retrosternal pain0.0
hypophosphatemia0.0
hyperphosphatemia0.0
agitation0.0
mouth dry0.0
colic abdominal0.0
hemorrhage rectum0.0
insomnia0.0
acne0.0
sweating increased0.0
lymphadenopathy0.0
dysesthesia0.0
nephrolithiasis0.0
photosensitivity0.0
dry eye0.0
weight decrease0.0
weight increase0.0
tooth disorder0.0
tinnitus0.0
thrombocytopenia0.0
syncope0.0
suicide attempt0.0
stomatitis0.0
stevens - johnson syndrome0.0
splenomegaly0.0
toothache0.0
tremor0.0
verruca0.0
vomiting0.0
urticaria0.0
urinary tract infection0.0
upper respiratory tract infection0.0
erythema0.0
unconsciousness0.0
ulceration0.0
hearing decreased0.0
acute myeloblastic leukemia0.0
abdominal pain0.0
chalazion0.0
chest pain0.0
confusion0.0
constipation0.0
cough0.0
dysphagia0.0
dehydration0.0
dermatitis0.0
dizziness0.0
dysarthria0.0
infectious diarrhea0.0
dyspepsia0.0
dyspnea0.0
earache0.0
eczema0.0
edema0.0
epistaxis0.0
cellulitis0.0
moniliasis0.0
abscess0.0
alopecia0.0
amnesia0.0
anemia0.0
hemolytic anemia0.0
angina0.0
anorexia0.0
anxiety0.0
arthralgia0.0
arthritis0.0
ascites0.0
weakness generalized0.0
ataxia0.0
back pain0.0
infection bacterial0.0
blepharitis0.0
bronchitis0.0
eructation0.0
cramps leg0.0
hyperbilirubinemia0.0
hypercalcemia0.0
hyperesthesia0.0
hyperkalemia0.0
hypernatremia0.0
hypertension0.0
portal hypertension0.0
hypocalcemia0.0
hypokalemia0.0
hyponatremia0.0
hypotension0.0
impotence0.0
infection0.0
influenza0.0
jaundice0.0
renal calculus0.0
laryngitis0.0
herpes zoster0.0
herpes simplex0.0
furunculosis0.0
folliculitis0.0
flushes0.0
flatulence0.0
fever0.0
fatigue0.0
rash0.0
esophagitis0.0
gastritis0.0
gingivitis0.0
hepatomegaly0.0
hemorrhoids0.0
hemoptysis0.0
heart valve disorder0.0
heart murmur0.0
headache0.0
hallucination0.0
glossitis0.0
hypothyroidism0
intracranial hemorrhage0
drug eruption0
asthma0
polyps0
heart disease0
mediastinal disorders0
conjunctivitis0
sgot increased0
pruritus ani0
ulcerative stomatitis0
connective tissue disorders0
neuropathy0
esophageal ulcer0
unconsciousness0
irritability0
menstrual disorder0
cyst0
heartburn0
cholelithiasis0
allergic rhinitis0
renal colic0
papilloma0
abdominal pain upper0
sclerosing cholangitis0
euphoria0
clotting0
malaise0
cerebrovascular accident0
elevated liver function tests0
retinitis0
psoriasis0
nausea0
fecal incontinence0
epididymitis0
gastroesophageal reflux0
cerebral hemorrhage0
renal insufficiency0
pruritus0
low back pain0
molluscum contagiosum0
menstrual irregularity0
myopathy0
diarrhea0
vertigo0
dry skin0
infestation0
endocrine disorders0
nocturia0
abdominal distention0
hypoglycemia0
sarcoma0
muscle weakness0