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Drug Details

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Name:Mibefradil
PubChem ID:60663
Pathway:Show KEGG pathways
InChI:InChI=1/C29H38FN3O3/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32)/t28-,29-/m0/s1/f/h31H
SMILES:CC(C)[C@H]1(c2ccc(cc2CC[C@]1(CCN(C)CCCc1[nH]c2ccccc2n1)OC(COC)=O)F)

Properties:
Formula:C29H38FN3O3Atoms:37
Molecular Weight:495.629Rotatable Bonds:12
H-bond Acceptors:7H-bond Donors:0
logP:5.2709
Targets:
NameUniprot IDSourceReferencesInteraction
AngiotensinogenANGT_HUMANSuperTargetPMID 16424797shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 010546924shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 010546924shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 010546924shows
Cytochrome P450 11B1, mitochondrialC11B1_HUMANSuperCypPMID 16424797shows
Cytochrome P450 11B2, mitochondrialC11B2_HUMANSuperCypPMID 16424797shows
Cytochrome P450 1A1CP1A1_HUMANSuperCypPMID 9211656shows
Cytochrome P450 1A2CP1A2_HUMANSuperCypPMID 9620098shows
Cytochrome P450 2D6CP2D6_HUMANSuperCypPMID 9211656shows
Cytochrome P450 3A4CP3A4_HUMANBindingDB-shows
Cytochrome P450 3A5CP3A5_HUMANSuperCypPMID 10215754shows
Cytochrome P450 3A7CP3A7_HUMANSuperCypPMID 9211656shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 010546924shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 010546924shows
Multidrug resistance protein 1MDR1_HUMANBindingDB-shows
Potassium voltage-gated channel subfamily H member 2KCNH2_HUMANBindingDB-shows
Sodium channel protein type 5 subunit alphaSCN5A_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit alpha-1CCAC1C_HUMANDrugBank-shows
Voltage-dependent L-type calcium channel subunit beta-1CACB1_HUMANDrugBank-shows
Voltage-dependent N-type calcium channel subunit alpha-1BCAC1B_HUMANBindingDB-shows
Voltage-dependent T-type calcium channel subunit alpha-1GCAC1G_HUMANBindingDB-shows
Voltage-dependent T-type calcium channel subunit alpha-1HCAC1H_HUMANBindingDB-shows
Voltage-dependent T-type calcium channel subunit alpha-1ICAC1I_HUMANBindingDB-shows
Synonyms:
(1S,2S)-2-(2-{[3-(1H-benzimidazol-2-yl)propyl](methyl)amino}ethyl)-6-fluoro-1-(1-methylethyl)-1,2,3,4-tetrahydronaphthalen-2-yl (methyloxy)acetate
(1S-cis)-2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro
(1S-cis)-2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate
116644-53-2
116666-63-8
2-(2-((3-(1H-Benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetate (1S-cis)-
Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-
C07222
C29H38FN3O3
DB01388
Lopac-M-5441
Lopac0_000748
LS-172325
Mibefradil
Mibefradil [INN:BAN]
NCGC00015683-01
NCGC00161420-01
NCGC00161420-03
Posicor
Ro 40-5967
[(1S,2S)-2-[2-[3-(1H-benzimidazol-2-yl)propyl-methylamino]ethyl]-6-fluoro-1-propan-2-yl-3,4-dihydro-1H-naphthalen-2-yl] 2-methoxyacetate
ATC-Codes: