Drug Details |  |
Name: | BICALUTAMIDE |  |
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PubChem ID: | 56069 |
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Pathway: | Show KEGG pathways |
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InChI: | InChI=1/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1/f/h24H
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SMILES: | C[C@](CS(c1ccc(cc1)F)(=O)=O)(C(Nc1ccc(C#N)c(c1)C(F)(F)F)=O)O |
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Properties: | Formula: | C18H14F4N2O4S | Atoms: | 29 |
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Molecular Weight: | 430.373 | Rotatable Bonds: | 7 |
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H-bond Acceptors: | 10 | H-bond Donors: | 0 |
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logP: | 4.03338 | | |
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Targets: | |
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Synonyms: | (+)-4'-cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide | (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide | (2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide | (2R)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2- | (2R)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE | (R)-Bicalutamide | 1z95 | 90357-06-5 | BICALUTAMIDE | Bicalutamide [USAN:BAN:INN] | BRN 5364666 | Casodex | CHEBI:3090 | DB01128 | DB02932 | ICI 176334 | NCGC00167487-01 | Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)- | R-BICALUTAMIDE | STOCK6S-47735 | ZINC00538564 |
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ATC-Codes: | |
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Side-Effects: | Side-Effect | Frequency |
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urticaria | 0.0010 | pulmonary fibrosis | 0.0010 | hypersensitivity | 0.0010 | interstitial lung disease | 0.0010 | angioneurotic edema | 0.0010 | interstitial pneumonitis | 0.0010 | pneumonia | 0 | pleural effusion | 0 | pharyngitis | 0 | periodontal abscess | 0 | pelvic pain | 0 | infection | 0 | pruritus | 0 | rhinitis | 0 | sinusitis | 0 | skin ulcer | 0 | cerebrovascular accident | 0 | sweating | 0 | syncope | 0 | paresthesia | 0 | pain | 0 | influenza | 0 | jaundice | 0 | kidney calculus | 0 | leg cramps | 0 | lung disorder | 0 | breast pain | 0 | mediastinal disorders | 0 | melena | 0 | myocardial infarction | 0 | nausea | 0 | tumor | 0 | nervousness | 0 | neutropenia | 0 | nocturia | 0 | thrombocytopenia | 0 | urinary incontinence | 0 | urinary tract infection | 0 | dry skin | 0 | deep thrombophlebitis | 0 | iron deficiency anemia | 0 | myalgia | 0 | sepsis | 0 | breast tenderness | 0 | rectal hemorrhage | 0 | bradycardia | 0 | laboratory test abnormal | 0 | neuropathy | 0 | urinary frequency | 0 | skin carcinoma | 0 | cerebral ischemia | 0 | insomnia | 0 | sgot increased | 0 | alkaline phosphatase increased | 0 | hepatic failure | 0 | abnormal vision | 0 | vomiting | 0 | weight gain | 0 | weight loss | 0 | dry mouth | 0 | urinary retention | 0 | chills | 0 | urinary urgency | 0 | peripheral edema | 0 | cataract | 0 | neck rigidity | 0 | liver function tests abnormal | 0 | bone pain | 0 | allergic reaction | 0 | abdominal pain | 0 | neck pain | 0 | chest pain | 0 | confusion | 0 | conjunctivitis | 0 | constipation | 0 | constitutional symptoms | 0 | coronary artery disease | 0 | cough | 0 | cyst | 0 | decreased libido | 0 | dysphagia | 0 | dehydration | 0 | diabetes mellitus | 0 | diarrhea | 0 | carcinoma | 0 | cancer | 0 | bronchitis | 0 | alopecia | 0 | anemia | 0 | hypochromic anemia | 0 | angina pectoris | 0 | anorexia | 0 | anxiety | 0 | arrhythmia | 0 | arthritis | 0 | asthenia | 0 | asthma | 0 | atrial fibrillation | 0 | back pain | 0 | balanitis | 0 | breast disorders | 0 | dizziness | 0 | somnolence | 0 | dyspepsia | 0 | heart failure | 0 | congestive heart failure | 0 | hematuria | 0 | hemorrhage | 0 | hernia | 0 | herpes zoster | 0 | hirsutism | 0 | hot flashes | 0 | hydronephrosis | 0 | hypercalcemia | 0 | hypercholesterolemia | 0 | hyperglycemia | 0 | hypertension | 0 | hypoglycemia | 0 | cardiac arrest | 0 | headache | 0 | gynecomastia | 0 | dyspnea | 0 | dysuria | 0 | ecchymosis | 0 | edema | 0 | eosinophilia | 0 | epistaxis | 0 | rash | 0 | fatigue | 0 | fever | 0 | flatulence | 0 | flushing | 0 | pathological fracture | 0 | gastritis | 0 | gout | 0 | impotence | 0 |
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