Drug Details

Name:

BICALUTAMIDE

PubChem ID:

56069

Pathway:

Show KEGG pathways

InChI:

InChI=1/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)/t17-/m0/s1/f/h24H

SMILES:

C[C@](CS(c1ccc(cc1)F)(=O)=O)(C(Nc1ccc(C#N)c(c1)C(F)(F)F)=O)O

Properties:

Formula:	C18H14F4N2O4S	Atoms:	29
Molecular Weight:	430.373	Rotatable Bonds:	7
H-bond Acceptors:	10	H-bond Donors:	0
logP:	4.03338

Targets:

Name	Uniprot ID	Source	References	Interaction
Androgen receptor	ANDR_HUMAN	DrugBank	-	shows
Androgen receptor	ANDR_RAT	DrugBank	-	shows
Androgen receptor	Q13771_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9BZG5_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9BZG6_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9BZG7_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9NUA2_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9UD95_HUMAN	SuperTarget	PMID 015001595	shows
Androgen receptor	Q9UN21_HUMAN	SuperTarget	PMID 015001595	shows
Cytochrome P450 2C19	CP2CJ_HUMAN	SuperCyp	PMID 15509184	shows
Cytochrome P450 2C9	CP2C9_HUMAN	SuperCyp	PMID 15509184	shows
Cytochrome P450 2D6	CP2D6_HUMAN	SuperCyp	PMID 15509184	shows
Cytochrome P450 3A4	CP3A4_HUMAN	SuperCyp	PMID 15509184	shows
Estrogen receptor beta	ESR2_HUMAN	DrugBank	-	shows
Interleukin-6	IL6_HUMAN	DrugBank	-	shows

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Synonyms:

(+)-4'-cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide

(+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide

(2R)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide

(2R)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-

(2R)-N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]-3-[(4-FLUOROPHENYL)SULFONYL]-2-HYDROXY-2-METHYLPROPANAMIDE

(R)-Bicalutamide

1z95

90357-06-5

BICALUTAMIDE

Bicalutamide [USAN:BAN:INN]

BRN 5364666

Casodex

CHEBI:3090

DB01128

DB02932

ICI 176334

NCGC00167487-01

Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-

R-BICALUTAMIDE

STOCK6S-47735

ZINC00538564

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ATC-Codes:

L02BB03

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Side-Effects:

Side-Effect	Frequency
urticaria	0.0010
pulmonary fibrosis	0.0010
hypersensitivity	0.0010
interstitial lung disease	0.0010
angioneurotic edema	0.0010
interstitial pneumonitis	0.0010
pneumonia	0
pleural effusion	0
pharyngitis	0
periodontal abscess	0
pelvic pain	0
infection	0
pruritus	0
rhinitis	0
sinusitis	0
skin ulcer	0
cerebrovascular accident	0
sweating	0
syncope	0
paresthesia	0
pain	0
influenza	0
jaundice	0
kidney calculus	0
leg cramps	0
lung disorder	0
breast pain	0
mediastinal disorders	0
melena	0
myocardial infarction	0
nausea	0
tumor	0
nervousness	0
neutropenia	0
nocturia	0
thrombocytopenia	0
urinary incontinence	0
urinary tract infection	0
dry skin	0
deep thrombophlebitis	0
iron deficiency anemia	0
myalgia	0
sepsis	0
breast tenderness	0
rectal hemorrhage	0
bradycardia	0
laboratory test abnormal	0
neuropathy	0
urinary frequency	0
skin carcinoma	0
cerebral ischemia	0
insomnia	0
sgot increased	0
alkaline phosphatase increased	0
hepatic failure	0
abnormal vision	0
vomiting	0
weight gain	0
weight loss	0
dry mouth	0
urinary retention	0
chills	0
urinary urgency	0
peripheral edema	0
cataract	0
neck rigidity	0
liver function tests abnormal	0
bone pain	0
allergic reaction	0
abdominal pain	0
neck pain	0
chest pain	0
confusion	0
conjunctivitis	0
constipation	0
constitutional symptoms	0
coronary artery disease	0
cough	0
cyst	0
decreased libido	0
dysphagia	0
dehydration	0
diabetes mellitus	0
diarrhea	0
carcinoma	0
cancer	0
bronchitis	0
alopecia	0
anemia	0
hypochromic anemia	0
angina pectoris	0
anorexia	0
anxiety	0
arrhythmia	0
arthritis	0
asthenia	0
asthma	0
atrial fibrillation	0
back pain	0
balanitis	0
breast disorders	0
dizziness	0
somnolence	0
dyspepsia	0
heart failure	0
congestive heart failure	0
hematuria	0
hemorrhage	0
hernia	0
herpes zoster	0
hirsutism	0
hot flashes	0
hydronephrosis	0
hypercalcemia	0
hypercholesterolemia	0
hyperglycemia	0
hypertension	0
hypoglycemia	0
cardiac arrest	0
headache	0
gynecomastia	0
dyspnea	0
dysuria	0
ecchymosis	0
edema	0
eosinophilia	0
epistaxis	0
rash	0
fatigue	0
fever	0
flatulence	0
flushing	0
pathological fracture	0
gastritis	0
gout	0
impotence	0

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