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Drug Details

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Name:TROGLITAZONE
PubChem ID:5591
Pathway:Show KEGG pathways
InChI:InChI=1/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)/f/h25H
SMILES:Cc1c(C)c2c(CCC(C)(COc3ccc(cc3)CC3C(NC(=O)S3)=O)O2)c(C)c1O

Properties:
Formula:C24H27NO5SAtoms:31
Molecular Weight:441.54Rotatable Bonds:5
H-bond Acceptors:6H-bond Donors:0
logP:4.703
Targets:
NameUniprot IDSourceReferencesInteraction
Amine oxidase [flavin-containing] BAOFB_HUMANBindingDB-shows
Bile salt export pumpABCBB_HUMANSuperTargetPMID 011179459shows
CREB3L2-PPARgammaQ86WD1_HUMANSuperTargetPMID 016303758shows
Cyclooxygenase 2Q99MH2_MOUSEPROMISCUOUSPMID 16446079shows
Cytochrome P450Q7Z448_HUMANSuperTargetPMID 012642470shows
Cytochrome P450Q86SK2_HUMANSuperTargetPMID 012642470shows
Cytochrome P450Q86SK3_HUMANSuperTargetPMID 012642470shows
Cytochrome P450 19A1CP19A_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 1A1CP1A1_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 2B6CP2B6_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 2C19CP2CJ_HUMANSuperCypPMID 10534310shows
Cytochrome P450 2C8CP2C8_HUMANPROMISCUOUSPMID 10534310shows
Cytochrome P450 2C9CP2C9_HUMANSuperCypPMID 10534310shows
Cytochrome P450 3A4CP3A4_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 3A5CP3A5_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 3A7CP3A7_HUMANPROMISCUOUSPMID 15860655shows
Cytochrome P450 CYP3A4Q9BZM0_HUMANSuperTargetPMID 012642470shows
Cytochrome P450 family 3 subfamily A polypeptide 4Q6GRK0_HUMANSuperTargetPMID 012642470shows
Equilibrative nucleoside transporter 1S29A1_HUMANDrugBank-shows
Interstitial collagenaseMMP1_HUMANPROMISCUOUSPMID 12921974shows
Long-chain-fatty-acid--CoA ligase 4ACSL4_HUMANDrugBank-shows
Matrix metalloproteinase 9Q9Y354_HUMANPROMISCUOUSPMID 10936484shows
Peroxisome proliferative activated receptor gammaQ4W448_HUMANSuperTargetPMID 016303758shows
Peroxisome proliferative activated receptor gammaQ4W4C6_HUMANSuperTargetPMID 016303758shows
Peroxisome proliferative activated receptor gammaQ4W4C7_HUMANSuperTargetPMID 016303758shows
Peroxisome proliferative activated receptor gamma isoform 2 variantQ53EW1_HUMANSuperTargetPMID 016303758shows
Peroxisome proliferator activated-receptor gammaQ9UEF6_HUMANSuperTargetPMID 016303758shows
Peroxisome proliferator-activated receptor alphaO75780_HUMANSuperTargetPMID 012044893shows
Peroxisome proliferator-activated receptor gammaPPARG_HUMANSuperTargetPMID 16965675shows
Peroxisome proliferator-activated receptor gamma 1Q6L9M1_HUMANSuperTargetPMID 016303758shows
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN_HUMANPROMISCUOUSPMID 16759638shows
Plasminogen activator inhibitor 1PAI1_HUMANDrugBank-shows
Protein kinaseQ60647_MOUSEPROMISCUOUSPMID 16452250shows
Protein kinaseQ64493_MOUSEPROMISCUOUSPMID 16452250shows
Protein kinaseQ64736_MOUSEPROMISCUOUSPMID 16452250shows
Protein kinaseQ78E06_MOUSEPROMISCUOUSPMID 16452250shows
Putative uncharacterized protein ABCB11Q53S60_HUMANSuperTargetPMID 011179459shows
Ribosomal protein S6 kinase beta-1KS6B1_BOVINPROMISCUOUSPMID 16825603shows
Serine/threonine-protein kinase mTORFRAP_MOUSEPROMISCUOUSPMID 16452250shows
Sister p-glycoproteinQ9UIL3_HUMANSuperTargetPMID 011179459shows
Testicular acid phosphatasePPAT_HUMANSuperTarget-shows
Tyrosine-protein phosphatase non-receptor type 1PTN1_HUMANBindingDB-shows
Synonyms:
()-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
(+)-all-rac-5-(p-((6-hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
(+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione
(+/-)-5-[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy)phenyl)methyl)-
2,4-Thiazolidinedione, 5-[[4-[(3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]- (9CI)
5-(4-((6-hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione)
5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine
5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione
5-[(4-{[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methyl]oxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
5-[[4-[(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
97322-87-7
BRN 4338399
C057693
C24H27NO5S
CCRIS 8969
CHEBI:9753
CI 991
CI-991
CS 045
CS-045
D00395
DB00197
GR 92132X
GR-92132X
HSCI1_000037
LS-151313
NCGC00161599-01
NCGC00161599-02
NCGC00161599-03
Noscal
Parke Davis brand of troglitazone
Prelay
Rezulin
Rezulin (TN)
Romglizone
Romozin
SMP2_000224
Spectrum5_001973
T2573_SIGMA
TROGLITAZONE
Troglitazone (JAN/USAN/INN)
Troglitazone [USAN:BAN:INN]
UPCMLD-DP017
UPCMLD-DP017:001
UPCMLD-DP017:002
Warner-Lambert brand of troglitazone
ATC-Codes:
Side-Effects:
Side-EffectFrequency
hepatitis0
fatigue0
anemia0
congestive heart failure0
syncope0
malaise0
abdominal pain0
fever0
anorexia0
vomiting0
jaundice0
liver function tests abnormal0
nausea0
edema0
weight gain0
hyperglycemia0