Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug Details

add
Name:Sunitinib
PubChem ID:5329102
Pathway:Show KEGG pathways
InChI:InChI=1/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-/f/h24,26H
SMILES:CCN(CC)CCNC(c1c(C)c(C(/[H])=C2/c3cc(ccc3NC2=O)F)[nH]c1C)=O

Properties:
Formula:C22H27FN4O2Atoms:30
Molecular Weight:398.474Rotatable Bonds:8
H-bond Acceptors:7H-bond Donors:0
logP:3.8638
Targets:
NameUniprot IDSourceReferencesInteraction
3-phosphoinositide-dependent protein kinase 1PDPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-1AAPK1_HUMANBindingDB-shows
5'-AMP-activated protein kinase catalytic subunit alpha-2AAPK2_HUMANBindingDB-shows
Acetyl-CoA carboxylaseO70151_RATPROMISCUOUSPMID 18815214shows
Activated CDC42 kinase 1ACK1_HUMANBindingDB-shows
Activin receptor type-1ACVR1_HUMANBindingDB-shows
Activin receptor type-1BACV1B_HUMANBindingDB-shows
Alpha-type platelet-derived growth factor receptorPGFRA_HUMANDrugBank-shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANDrugBank-shows
cAMP-dependent protein kinase catalytic subunit alphaKAPCA_HUMANBindingDB-shows
cAMP-dependent protein kinase catalytic subunit betaKAPCB_HUMANBindingDB-shows
Casein kinase I isoform gamma-2KC1G2_HUMANBindingDB-shows
Casein kinase II subunit alphaCSK21_HUMANBindingDB-shows
Cell division protein kinase 2CDK2_HUMANBindingDB-shows
Cell division protein kinase 5CDK5_HUMANBindingDB-shows
Cell division protein kinase 7CDK7_HUMANBindingDB-shows
Cell division protein kinase 8CDK8_HUMANBindingDB-shows
Cell division protein kinase 9CDK9_HUMANBindingDB-shows
Cytochrome P450 3A4CP3A4_HUMANPROMISCUOUSPMID 17825686shows
Death-associated protein kinase 1DAPK1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 1MP2K1_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 2MP2K2_HUMANBindingDB-shows
Dual specificity mitogen-activated protein kinase kinase 4MP2K4_HUMANBindingDB-shows
Dual specificity protein kinase CLK1CLK1_HUMANBindingDB-shows
Ephrin type-A receptor 2EPHA2_HUMANBindingDB-shows
Ephrin type-B receptor 1EPHB1_HUMANBindingDB-shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
Epithelial discoidin domain-containing receptor 1DDR1_HUMANBindingDB-shows
Fibroblast growth factor receptor 2FGFR2_HUMANBindingDB-shows
Fibroblast growth factor receptor 3FGFR3_HUMANBindingDB-shows
Fibroblast growth factor receptor 4FGFR4_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANDrugBank-shows
Focal adhesion kinase 1FAK1_HUMANBindingDB-shows
Glycogen synthase kinase-3 alphaGSK3A_HUMANBindingDB-shows
Glycogen synthase kinase-3 betaGSK3B_HUMANBindingDB-shows
Hepatocyte growth factor receptorMET_HUMANBindingDB-shows
High affinity nerve growth factor receptorNTRK1_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit alphaIKKA_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit betaIKKB_HUMANBindingDB-shows
Inhibitor of nuclear factor kappa-B kinase subunit epsilonIKKE_HUMANBindingDB-shows
Insulin receptorINSR_HUMANBindingDB-shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANDrugBank-shows
MAP kinase-activated protein kinase 2MAPK2_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANDrugBank-shows
Mitogen-activated protein kinase 1MK01_HUMANBindingDB-shows
Mitogen-activated protein kinase 10MK10_HUMANBindingDB-shows
Mitogen-activated protein kinase 12MK12_HUMANBindingDB-shows
Mitogen-activated protein kinase 14MK14_HUMANBindingDB-shows
Mitogen-activated protein kinase 3MK03_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoformPK3CA_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoformPK3CB_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoformPK3CD_HUMANBindingDB-shows
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPK3CG_HUMANBindingDB-shows
Protein kinase C alpha typeKPCA_HUMANBindingDB-shows
Protein kinase C epsilon typeKPCE_HUMANBindingDB-shows
Protein kinase C theta typeKPCT_HUMANBindingDB-shows
Protein tyrosine kinase 2 betaFAK2_HUMANBindingDB-shows
Protein-tyrosine kinase IIB, 38KQ7M0B5_RATPROMISCUOUSPMID 18815214shows
Proto-oncogene serine/threonine-protein kinase Pim-1PIM1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase FynFYN_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase LCKLCK_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANDrugBank-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase YesYES_HUMANBindingDB-shows
RAC-alpha serine/threonine-protein kinaseAKT1_HUMANPROMISCUOUSPMID 16916320shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Receptor-interacting serine/threonine-protein kinase 1RIPK1_HUMANBindingDB-shows
Rho-associated protein kinase 1ROCK1_HUMANBindingDB-shows
Ribosomal protein S6 kinase alpha-5KS6A5_HUMANBindingDB-shows
Ribosomal protein S6 kinase beta-1KS6B1_HUMANPROMISCUOUSPMID 17983653shows
Serine/threonine-protein kinase 6STK6_HUMANBindingDB-shows
Serine/threonine-protein kinase D1KPCD1_HUMANBindingDB-shows
Serine/threonine-protein kinase PLK1PLK1_HUMANBindingDB-shows
Serine/threonine-protein kinase receptor R3ACVL1_HUMANBindingDB-shows
TGF-beta receptor type-2TGFR2_HUMANBindingDB-shows
Tubulin alpha-1A chainTBA1A_HUMANBindingDB-shows
Tyrosine-protein kinase ABL2ABL2_HUMANBindingDB-shows
Tyrosine-protein kinase BTKBTK_HUMANBindingDB-shows
Tyrosine-protein kinase CSKCSK_HUMANBindingDB-shows
Tyrosine-protein kinase HCKHCK_HUMANBindingDB-shows
Tyrosine-protein kinase ITK/TSKITK_HUMANBindingDB-shows
Tyrosine-protein kinase JAK2JAK2_HUMANBindingDB-shows
Tyrosine-protein kinase JAK3JAK3_HUMANBindingDB-shows
Tyrosine-protein kinase receptor TYRO3TYRO3_HUMANBindingDB-shows
Tyrosine-protein kinase SYKKSYK_HUMANBindingDB-shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANDrugBank-shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANDrugBank-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANDrugBank-shows
Wee1-like protein kinaseWEE1_HUMANBindingDB-shows
Synonyms:
1H-Pyrrole-3-carboxamide,
1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-
1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)- (5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
326914-13-0
557795-19-4
CHEBI:38940
DB01268
K00588a
LS-187023
LS-187648
N-(2-diethylaminoethyl)-5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
NCGC00164631-01
NSC736511
PDGF TK antagonist
STOCK6S-48542
SU 11248
Su-011248
SU-11248
SU-11248J
SU-12662
SU11248
Sunitanib
Sunitinib
Sunitinib malate
Sutent
ATC-Codes:
Side-Effects:
Side-EffectFrequency
thrombotic microangiopathy0.0010
proteinuria0.0010
nephrotic syndrome0.0010
seizures0
stomatitis0
cerebrovascular accident0
thrombocytopenia0
thyroiditis0
thyrotoxicosis0
erythema0
vascular disorders0
rhabdomyolysis0
lymphopenia0
mediastinal disorders0
nausea0
neutropenia0
pain0
pain in limb0
pancreatitis0
peripheral neuropathy0
pulmonary embolism0
abnormal vision0
vomiting0
weight loss0
hypopigmentation0
oral pain0
myalgia0
abdominal pain upper0
depressed mood0
bradycardia0
blindness0
lung cancer0
hyperuricemia0
deep thrombophlebitis0
dry skin0
dry mouth0
chills0
hepatic failure0
peripheral edema0
hypophosphatemia0
deep vein thrombosis0
amylase increased0
myocardial ischemia0
alkaline phosphatase increased0
insomnia0
leukopenia0
abdominal pain0
constitutional symptoms0
cough0
dehydration0
diarrhea0
dizziness0
dyspepsia0
dyspnea0
edema0
epistaxis0
constipation0
connective tissue disorders0
adrenal insufficiency0
alopecia0
anemia0
anorexia0
arrhythmia0
arthralgia0
asthenia0
back pain0
blistering0
reflux esophagitis0
rash0
fatigue0
hyperkalemia0
hypernatremia0
hypertension0
hypocalcemia0
hypoglycemia0
hypokalemia0
hyponatremia0
hypothyroidism0
infection0
hyperglycemia0
hypercalcemia0
fever0
flank pain0
flatulence0
gastroesophageal reflux0
glossodynia0
headache0
congestive heart failure0
hemoptysis0
hemorrhage0
jaundice0