Home
Drugs
Targets
Pathways
Ontologies
Cyp450s
Adv.search
Help/FAQ

Drug Details

add
Name:Semaxinib
PubChem ID:5329098
Pathway:Show KEGG pathways
InChI:InChI=1/C15H14N2O/c1-9-7-10(2)16-14(9)8-12-11-5-3-4-6-13(11)17-15(12)18/h3-8,16H,1-2H3,(H,17,18)/b12-8-/f/h17H
SMILES:Cc1cc(C)[nH]c1C(/[H])=C1/c2ccccc2NC1=O

Properties:
Formula:C15H14N2OAtoms:19
Molecular Weight:238.284Rotatable Bonds:1
H-bond Acceptors:3H-bond Donors:0
logP:3.2622
Targets:
NameUniprot IDSourceReferencesInteraction
72 kDa type IV collagenaseMMP2_HUMANPROMISCUOUSPMID 12777073shows
Basic fibroblast growth factor receptor 1FGFR1_HUMANBindingDB-shows
Beta-type platelet-derived growth factor receptorPGFRB_HUMANBindingDB-shows
CD24B6EC88_HUMANPROMISCUOUSPMID 12657164shows
Epidermal growth factor receptorEGFR_HUMANBindingDB-shows
FL cytokine receptorFLT3_HUMANBindingDB-shows
Growth factor receptorQ71UK0_MOUSEPROMISCUOUSPMID 9892193shows
Insulin-like growth factor 1 receptorIGF1R_HUMANBindingDB-shows
Macrophage colony-stimulating factor 1 receptorCSF1R_HUMANBindingDB-shows
Mast/stem cell growth factor receptorKIT_HUMANBindingDB-shows
Matrix metalloproteinase 9Q9Y354_HUMANPROMISCUOUSPMID 12657164shows
Nitric oxide synthase, brainNOS1_RATPROMISCUOUSPMID 15064225shows
Nitric oxide synthase, endothelialNOS3_RATPROMISCUOUSPMID 15064225shows
Nitric oxide synthase, inducibleNOS2_RATPROMISCUOUSPMID 15064225shows
Prostate-specific antigenKLK3_HUMANPROMISCUOUSPMID 15161690shows
Protein-tyrosine kinase IIB, 38KQ7M0B5_RATPROMISCUOUSPMID 17332430shows
Proto-oncogene tyrosine-protein kinase ABL1ABL1_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase receptor retRET_HUMANBindingDB-shows
Proto-oncogene tyrosine-protein kinase SrcSRC_HUMANBindingDB-shows
Receptor tyrosine-protein kinase erbB-2ERBB2_HUMANBindingDB-shows
Signal transducer CD24CD24_HUMANPROMISCUOUSPMID 12657164shows
Stromelysin-1MMP3_HUMANPROMISCUOUSPMID 12777073shows
Tyrosine-protein kinase ZAP-70ZAP70_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 1VGFR1_HUMANPROMISCUOUSPMID 12489845shows
Vascular endothelial growth factor receptor 2VGFR2_HUMANBindingDB-shows
Vascular endothelial growth factor receptor 3VGFR3_HUMANBindingDB-shows
Synonyms:
"insolution™ vegf receptor 2 kinase inhibitor iii"
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-o
(3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
1,3-Dihydro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-2H-indol-2-one
194413-58-6
204005-46-9
2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (3Z)-
2H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-, (Z)-
2H-Indol-2-one, 3-[(3,5-dimethyl-2-pyrrolyl)methylene]-
3-((Z)-(3,5-Dimethylpyrrol-2-yl)methylene)-2-indolinone
3-(1-(3,5-Dimethyl-1H-pyrrol-2-yl)meth-(Z)-ylidene)-2-oxo-2,3-dihydroindole
3-(2,4-dimethylpyrrol-5-yl)methylidene-indolin-2-one
3-[(2,4-Dimethylpyrrol-5-yl)methylidene]-indolin-2-one
3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]indolin-2-one
3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one
C116890
D05819
EU-0101110
H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-
HSCI1_000303
InSolution™ VEGF Receptor 2 Kinase Inhibitor III
Lopac0_001110
LS-193151
LS-83886
MLS001074896
MLS001332519
MLS001332520
NCGC00094381-01
NCGC00094381-02
NCGC00094381-03
nchembio778-comp2
NSC-696819
NSC696819
S8442_SIGMA
Semaxanib
Semaxanib (USAN/INN)
Semaxanib [INN]
Semaxinib
Semaxnib
Semoxind
SMR000568416
SU 5416
SU-5416
SU5416
TSU-16
VEGF Receptor 2 Kinase Inhibitor III