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Name:RAPAMYCIN IMMUNOSUPPRESSANT DRUG
PubChem ID:5284616
Pathway:Show KEGG pathways
InChI:InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1
SMILES:-

Properties:
Formula:C51H79NO13Atoms:85
Molecular Weight:914.172Rotatable Bonds:6
H-bond Acceptors:13H-bond Donors:0
logP:6.1185
Targets:
NameUniprot IDSourceReferencesInteraction
cDNA FLJ46716 fis, clone TRACH3018108, highly similar to 51 kDa FK506-binding proteinQ6ZR21_HUMANSuperTargetPMID 015878982shows
Cytochrome P450 3A4CP3A4_HUMANSuperCypPMID 11384247shows
Cytochrome P450 3A5CP3A5_HUMANSuperCyp-shows
Cytochrome P450 3A7CP3A7_HUMANSuperCyp-shows
DJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)Q96QW8_HUMANSuperTargetPMID 010318894shows
FK506 binding protein 1A, 12kDaQ5W0X3_HUMANSuperTargetPMID 011930000shows
FK506 binding protein 2, 13kDaQ53XJ5_HUMANSuperTargetPMID 007505249shows
FK506 binding protein 5Q5TGM6_HUMANSuperTargetPMID 015878982shows
FK506 binding protein 5 variantQ53GX4_HUMANSuperTargetPMID 015878982shows
FK506-binding protein 2FKBP2_HUMANSuperTargetPMID 007505249shows
FK506-binding protein 3FKBP3_HUMANDrugBank-shows
FK506-binding protein 3 variantQ53GD8_HUMANSuperTargetPMID 001371698shows
FK506-binding protein 4FKBP4_HUMANSuperTargetPMID 007521210shows
FK506-binding protein 5FKBP5_HUMANSuperTargetPMID 015878982shows
FKBP-12Q9UH88_HUMANSuperTargetPMID 011930000shows
FRAP1 variant proteinQ4LE76_HUMANSuperTargetPMID 010318894shows
Kappa-type opioid receptorOPRK_HUMANSuperTarget-shows
Multidrug resistance protein 1MDR1_HUMANSuperTargetPMID 011907172shows
Multidrug resistance protein 1 variantQ59GY9_HUMANSuperTargetPMID 011907172shows
P-glycoproteinO60213_HUMANSuperTargetPMID 011907172shows
P-glycoprotein 1Q6TBL4_HUMANSuperTargetPMID 011907172shows
Peptidyl-prolyl cis-trans isomerase FKBP1AFKB1A_HUMANBindingDB-shows
Peptidyl-prolyl cis-trans isomerase FKBP1AFKB1A_RABITBindingDB-shows
Peptidyl-prolyl cis-trans isomerase FKBP1AFKB1A_BOVINDrugBank-shows
Peptidyl-prolyl cis-trans isomerase FKBP1BFKB1B_HUMANDrugBank-shows
Serine/threonine-protein kinase mTORFRAP_HUMANSuperTargetPMID 010318894shows
Synonyms:
(-)-Rapamycin
(-)-Rapamycin;Rapamune
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
(1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34 aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hex adecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-hydro xy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy- 6,8,12,14,20,26-hexamethyl-23,27-ep
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-4,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-heptadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-223,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-
(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS)-9,27-dihydroxy-3-{(1R)-2-[(1S,3R,4R)-4-hydroxy-3-(methyloxy)cyclohexyl]-1-methylethyl}-6,8,12,14,20,26-hexamethyl-10,21-bis(methyloxy)-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29(6H,31H)-pentone
1fkb
1pbk
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*(S*(1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))-
23,27-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-(3-(4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, (3S-(3R*(S*(1R*,3S*,4S*)),6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*))
23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine
53123-88-9
AIDS-093492
AIDS093492
Antibiotic AY 22989
AY 22989
AY-22989
BiomolKI2_000084
C51H79NO13
CCRIS 9024
CHEBI:100923
HSDB 7284
LCP-Siro
LS-143290
MS-R001
NCGC00021305-05
nchembio.100-comp4
nchembio.2007.42-comp2
nchembio.79-comp1
nchembio762-comp1
nchembio883-comp3
NSC 226080
NSC226080
Perceiva
R0395_SIAL
R0395_SIGMA
RAP
RAPA
RAPAMUNE
Rapamycin
Rapamycin from Streptomyces hygroscopicus
RAPAMYCIN IMMUNOSUPPRESSANT DRUG
SILA 9268A
Sirolimus
Sirolimus (RAPAMUNE)
Sirolimus [USAN:BAN:INN]
Sirolimus, Rapamune,Rapamycin
WY-090217
ATC-Codes: